Aluminum exposure and toxicity in neonates: a practical guide to halt aluminum overload in the prenatal and perinatal periods
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During the last years, human newborns have been overexposed to biologically reactive aluminum, with possible relevant consequences on their future health and on their susceptibility to a variety of diseases. Children, newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative immaturity.
Based on recent original publications and classical data of the literatures, we reviewed the aluminum content in mother’s food during the intrauterine life as well as in breast milk and infant formula during lactation. We also determined the possible role of aluminum in parenteral nutrition solutions, in adjuvants of vaccines and in pharmaceutical products. A special focus is placed on the relationship between aluminum overexposure and the insurgence of bone diseases.
Practical points of management and prevention are suggested. Aluminum sources that infants may receive during the first 6 months of life are presented. In the context of prevention of possible adverse effects of aluminum overload in fetal tissues during development, simple suggestions to pregnant women are described. Finally, practical points of management and prevention are suggested.
Pediatricians and neonatologists must be more concerned about aluminum content in all products our newborns are exposed to, starting from monitoring aluminum concentrations in milk- and soybased formulas in which, on the basis of recent studies, there is still too much aluminum.
Key wordsaluminum fetus newborn toxicity
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- 2.American Academy of Pediatrics Committee on Nutrition: Aluminum toxicity ininfants and children. Pediatrics 1986;78:1150–1154.Google Scholar
- 6.Food and Drug Administration. Amendment of regulations on aluminum in large and small volume parenteral used in total parenteral nutrition; delay of effective date. Federal Registry 2003;68:32979–32981.Google Scholar
- 12.Quigley MA, Henderson G, Anthony MY, McGuire W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev 2007;17:CD002971.Google Scholar
- 16.Aluminum toxicity in infants and children. American Academy of Pediatrics, Committee on Nutrition. Pediatrics 1996;97:413–416.Google Scholar
- 18.Levels of aluminum in infant formulae. Lancet 1989;1:1024–1025.Google Scholar
- 30.Sears RW. Is aluminum the new thimerosal? Mothering 2008;146:46–53.Google Scholar
- 31.Clements CJ, Griffiths E. The global impact of vaccines containing aluminum adjuvants. Vaccine 2001;20 Suppl 3:S24–S33.Google Scholar
- 62.Exley C. Aluminum and Medicine. In: Mercè ALR, Felcman J, Recio MAL, eds. Molecular and supramolecular bioinorganic chemistry. Applications in medical sciences. Happauge, NY: Nova Biomedical Books, 2009.Google Scholar