World Journal of Pediatrics

, Volume 10, Issue 1, pp 53–58 | Cite as

Neonatal outcomes of very preterm infants from a neonatal intensive care center

  • Wei-Qin Zhou
  • Ya-Bo Mei
  • Xiao-Ying Zhang
  • Qiu-Ping Li
  • Xiang-Yong Kong
  • Zhi-Chun Feng
Original article



Information about clinical outcomes of very preterm (VPT) infants in tertiary neonatal intensive care unit (NICU) setting is scant in China. This study aimed to investigate the mortality and morbidity of VPT infants admitted to BaYi Children’s Hospital, which serves as a NICU referral center for the city of Beijing, China.


Retrospectively collected perinatal/neonatal data on all admissions of infants born at <32 weeks of gestational age and subsequently admitted to the VPTNICU from clinical records between October 2010 and September 2011.


Totally 729 infants were identified. 90% of VPT infants were outborn. The overall survival of the infants to discharge was 92%, which increased with increasing gestational age (range from 69% at <28 weeks to 99% at 31 weeks). The incidence of bronchopulmonary dysplasia was 4%, retinopathy of prematurity requiring treatment 2%, intraventricular hemorrhage III-IV 6%, and periventricular leukomalacia 2%. 10% of the VPT infants had a major morbidity at discharge.


The outcomes of the VTP infants at this referral NICU were comparable to those in tertiary centers in developed countries. The most common complications were lower than those in other cohorts. Accordingly, high-volume NICU may minimize the adverse effects of VPT infants’ transport.

Key words

morbidity mortality transport very preterm 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Sun B, Qian LL, Liu CQ, Wang SN, Yu JL, Cheng XY. International perspectives: development of perinatal-neonatal medicine in China. Neoreviews 2008;9:e95–e101.CrossRefGoogle Scholar
  2. 2.
    Lasswell SM, Barfield WD, Rochat RW, Blackmon L. Perinatal regionalization for very low-birth-weight and very preterm infants: a meta-analysis. JAMA 2010;304:992–1000.PubMedCrossRefGoogle Scholar
  3. 3.
    American Academy of Pediatrics Committee on Fetus And Newborn. Levels of neonatal care. Pediatrics 2012;130:587–597.CrossRefGoogle Scholar
  4. 4.
    Qian L, Liu C, Zhuang W, Guo Y, Yu J, Chen H, et al. Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. Pediatrics 2008;121:e1115–1124.PubMedCrossRefGoogle Scholar
  5. 5.
    Ma L, Liu C, Wang Y, Li S, Zhai S, Gu X, et al. Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China. Neonatology 2011;100:14–22.PubMedCrossRefGoogle Scholar
  6. 6.
    Sun B, Ma L, Liu X, Gao X, Ni L. Development of neonatal respiratory and intensive care: Chinese perspectives. Neonatology 2012;101:77–82.PubMedCrossRefGoogle Scholar
  7. 7.
    Wang H, Gao X, Liu C, Yan C, Lin X, Yang C, et al. Morbidity and mortality of neonatal respiratory failure in China: surfactant treatment in very immature infants. Pediatrics 2012;129:e731–740.PubMedCrossRefGoogle Scholar
  8. 8.
    International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol 2005;123:991–999.CrossRefGoogle Scholar
  9. 9.
    Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978;187:1–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 gm. J Pediatr 1978;92:529–534.PubMedCrossRefGoogle Scholar
  11. 11.
    de Vries LS, Eken P, Dubowitz LM. The spectrum of leukomalacia using cranial ultrasound. Behav Brain Res 1992;49:1–6.PubMedCrossRefGoogle Scholar
  12. 12.
    US Department of Health and Human Services, Public Health Service. Healthy people 2010: National Health Promotion and Disease Prevention Objectives. 2nd ed. Rockville, MD: Office of Disease Prevention and Health Promotion, 2001.Google Scholar
  13. 13.
    Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW deliveries at subspecialty perinatal centers via perinatal outreach. Pediatrics 2011;127:487–493.PubMedCrossRefGoogle Scholar
  14. 14.
    Gortner L, Misselwitz B, Milligan D, Zeitlin J, Kollée L, Boerch K, et al. Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC cohort. Neonatology 2011;99:112–117.PubMedCrossRefGoogle Scholar
  15. 15.
    Jakuskiene R, Vollmer B, Saferis V, Daugeliene D. Neonatal outcomes of very preterm infants admitted to a tertiary center in Lithuania between the years 2003 and 2005. Eur J Pediatr 2011;170:1293–1303.PubMedCrossRefGoogle Scholar
  16. 16.
    Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006:CD004454.Google Scholar
  17. 17.
    Carlo WA, McDonald SA, Fanaroff AA, Vohr BR, Stoll BJ, Ehrenkranz RA, et al. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks’ gestation. JAMA 2011;306:2348–2358.PubMedCentralPubMedCrossRefGoogle Scholar
  18. 18.
    Smith PB, Ambalavanan N, Li L, Cotten CM, Laughon M, Walsh MC, et al. Approach to infants born at 22 to 24 weeks’ gestation: relationship to outcomes of more-mature infants. Pediatrics 2012;129:e1508–1516.PubMedCrossRefGoogle Scholar
  19. 19.
    Aladangady N, de Rooy L. Withholding or withdrawal of life sustaining treatment for newborn infants. Early Hum Dev 2012;88:65–69.PubMedCrossRefGoogle Scholar
  20. 20.
    de Waal CG, Weisglas-Kuperus N, van Goudoever JB, Walther FJ; NeoNed Study Group; LNF Study Group. Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. PLoS One 2012;7:e41302.PubMedCentralPubMedCrossRefGoogle Scholar
  21. 21.
    Phibbs CS, Baker LC, Caughey AB, Danielsen B, Schmitt SK, Phibbs RH. Level and volume of neonatal intensive care and mortality in very-low-birth-weight infants. N Engl J Med 2007;356:2165–2175.PubMedCrossRefGoogle Scholar
  22. 22.
    Bartels DB, Wypij D, Wenzlaff P, Dammann O, Poets CF. Hospital volume and neonatal mortality among very low birth weight infants. Pediatrics 2006;117:2206–2214.PubMedCrossRefGoogle Scholar
  23. 23.
    Feng ZC. To establish the classification and admittance system of neonatal intensive care units in China. Zhonghua Er Ke Za Zhi 2009;47:644–647.PubMedGoogle Scholar

Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Wei-Qin Zhou
    • 1
  • Ya-Bo Mei
    • 1
  • Xiao-Ying Zhang
    • 1
  • Qiu-Ping Li
    • 1
  • Xiang-Yong Kong
    • 1
  • Zhi-Chun Feng
    • 1
    • 2
  1. 1.Department of Pediatrics, BaYi Children’s Hospital Affiliated to the Clinical Medical College of the General Hospital of Beijing Military RegionSouthern Medical UniversityBeijingChina
  2. 2.Department of Pediatrics, BaYi Children’s Hospital Affiliated to the Clinical Medical College of the General Hospital of Beijing Military RegionSouthern Medical UniversityBeijingChina

Personalised recommendations