Radiation exposure in extremely low birth weight infants during their neonatal intensive care unit stay
- 211 Downloads
Extremely low birth weight (ELBW <1000 g) infants may have increased sensitivity to radiation exposure. Our objective was to estimate the radiation exposure in survivors of ELBW infants during their neonatal intensive care unit (NICU) stay.
In this retrospective cohort study, medical records of all ELBW infants who had been admitted to our NICU between May 1999 and October 2009 were reviewed. The infants’ total entrance skin exposure [ESE in micro-Gray (μGy)] was estimated.
Among 450 survivors, the mean gestational age (GA) was 26.3±2.1 weeks, and the mean birth weight (BW) was 774.2±144.4 g. Infants received a median of 32 (range: 1–159) X-rays, with an estimated ESE of 1471 μGy (range: 28–9264). Total ESE was inversely proportional to GA (r=−0.34; P<0.01), and BW (r=−0.39; P=0.01) and proportional to the severity of illness [score for neonatal acute physiology-perinatal extension (SNAPPE), r=0.39; P=0.01]. In a linear regression analysis, GA, SNAPPE and necrotizing enterocolitis were associated with radiation exposure (ESE) in ELBW infants (r2=0.133; P<0.001).
During their NICU stay, ELBW infants were subjected to a significant number of diagnostic X-ray procedures. Our data highlight the need to closely monitor the number of X-ray procedures ordered to ELBW infants to avoid unnecessary radiation exposure.
Key wordsentrance skin exposure extremely low birth weight infants radiation exposure
Unable to display preview. Download preview PDF.
- 11.The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann ICRP 2007;37:9–34.Google Scholar
- 12.Council Directive 97/43 Eurotom of 30 June 1997 on health protection of individuals against the dangers of ionizing radiation in relation to medical exposure, and repealing Directive 84/466/Eurotom. Official Journal L 180, 1997: 0022–0027.Google Scholar
- 13.Radiological protection and safety in medicine. A report of the International Commission on Radiological Protection. Ann ICRP 1996;26:1–47.Google Scholar
- 14.Center for Drug Evaluation and Research UFaDA. White Paper: Initiative to Reduce Unnecessary Radiation Exposure from Medical Imaging. Center for Drug Evaluation and Research, US Food and Drug Administration, 2010. http://www.fda.gov/Radiation-EmittingProducts/RadiationSafety/RadiationDoseReduction/ucm199994.htm (accessed December 19, 2011).Google Scholar
- 15.Radiation risks of diagnostic imaging. The Joint Commission. Sentinel Event Alert 2011; (4):1–4.Google Scholar
- 17.NRC. Health risks from exposure to low levels of ionizing radiation: BEIR VII-Phase 2. National Research Council. Washington D.C: The National Academies Press, 2006: 281.Google Scholar