World Journal of Pediatrics

, Volume 9, Issue 1, pp 9–16

Updated diagnosis and treatment of childhood tuberculosis

  • Shou-Chien Chen
  • Kwo-Liang Chen
  • Kou-Huang Chen
  • Shun-Tien Chien
  • Kow-Tong Chen
Review article



Childhood tuberculosis (TB) accounts for a significant proportion of the global tuberculosis disease burden. However, current and previous efforts to develop better diagnostic, therapeutic, and preventive interventions have focused on TB in adults, and childhood TB has been relatively neglected. The purpose of this review is to provide an update on the diagnostic and therapeutic recommendations for childhood TB with an emphasis on intrathoracic disease.

Data sources

The literature from a range of sources was reviewed and synthesized to provide an overview of the contemporary approaches for the diagnosis and treatment of childhood TB.


This review summarizes the clinical, radiological, bacteriological, and immunological approaches to diagnose TB infection and disease in children. In addition, we summarize the updated guidelines for the treatment of TB in children.


The development of better diagnostic and therapeutic methods for childhood TB remains a significant challenge. As the strategies for diagnosis and treatment of childhood TB continue to improve and the knowledge base increases, the implementation of these strategies will be crucial.

Key words

childhood diagnosis treatment tuberculosis 


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Shou-Chien Chen
    • 1
    • 2
  • Kwo-Liang Chen
    • 3
  • Kou-Huang Chen
    • 3
  • Shun-Tien Chien
    • 4
  • Kow-Tong Chen
    • 5
    • 6
  1. 1.Department of Family MedicineDa-Chien General HospitalTaiwanChina
  2. 2.General Education CenterTa Tung UniversityTaiwanChina
  3. 3.Department of Industrial Engineering and ManagementChina University of Science and TechnologyTaiwanChina
  4. 4.Chest Hospital, Department of HealthExecutive YuanTaiwanChina
  5. 5.Department of Public Health, College of MedicineNational Cheng Kung UniversityTainanChina
  6. 6.Department of Public Health, College of MedicineNational Cheng-Kung UniversityTaiwanChina

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