World Journal of Pediatrics

, Volume 9, Issue 1, pp 17–24

Incidence of brain injuries in premature infants with gestational age ≤34 weeks in ten urban hospitals in China

  • Hui-Jin Chen
  • Ke-Lun Wei
  • Cong-Le Zhou
  • Yu-Jia Yao
  • Yu-Jia Yang
  • Xiu-Fang Fan
  • Xi-Rong Gao
  • Xiao-Hong Liu
  • Ji-Hong Qian
  • Ben-Qing Wu
  • Gao-Qiang Wu
  • Qing-Mei Zhang
  • Xiao-Lan Zhang
Original article

DOI: 10.1007/s12519-012-0395-8

Cite this article as:
Chen, HJ., Wei, KL., Zhou, CL. et al. World J Pediatr (2013) 9: 17. doi:10.1007/s12519-012-0395-8
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Abstract

Background

There is a large number (1.5 million per year) of premature births in China. It is necessary to obtain the authentic incidences of intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), the common brain injuries, in Chinese premature infants. The present multicenter study aimed to investigate the incidence of brain injuries in premature infants in ten urban hospitals in China.

Methods

The research proposal was designed by the Subspecialty Group of Neonatology of Pediatric Society of the Chinese Medical Association. Ten large-scale urban hospitals voluntarily joined the multicenter investigation. All premature infants with a gestational age ≤34 weeks in the ten hospitals were subjected to routine cranial ultrasound within three days after birth, and then to repeated ultrasound every 3–7 days till their discharge from the hospital from January 2005 to August 2006. A uniform data collection sheet was designed to record cases of brain injuries.

Results

The incidences of overall IVH and severe IVH were 19.7% (305/1551) and 4.6% (72/1551), respectively with 18.4% (56/305) for grade 1, 58.0% (177/305) for grade 2, 17.7% (54/305) for grade 3 and 5.9% (18/305) for grade 4 in nine hospitals. The incidences of overall PVL and cystic PVL were 5.0% (89/1792) and 0.8% (14/1792) respectively, with 84.3% (75/89) for grade 1, 13.5% (12/89) for grade 2, and 2.2% (2/89) for grade 3 in the ten hospitals. The statistically significant risk factors that might aggravate the severity of IVH were vaginal delivery (OR=1.883, 95% CI: 1.099–3.228, P=0.020) and mechanical ventilation (OR=4.150, 95% CI: 2.384–7.223, P=0.000). The risk factors that might result in the development of cystic PVL was vaginal delivery (OR=21.094, 95% CI: 2.650–167.895, P=0.000).

Conclusions

The investigative report can basically reflect the incidence of brain injuries in premature infants in major big cities of China. Since more than 60% of the Chinese population live in the rural areas of China, it is expected to undertake a further multicenter investigation covering the rural areas in the future.

Key words

incidence intraventricular hemorrhage multicenter investigation periventricular leukomalacia premature infants 

Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Hui-Jin Chen
    • 1
  • Ke-Lun Wei
    • 2
  • Cong-Le Zhou
    • 3
  • Yu-Jia Yao
    • 4
  • Yu-Jia Yang
    • 5
  • Xiu-Fang Fan
    • 6
  • Xi-Rong Gao
    • 7
  • Xiao-Hong Liu
    • 8
  • Ji-Hong Qian
    • 9
  • Ben-Qing Wu
    • 10
  • Gao-Qiang Wu
    • 11
  • Qing-Mei Zhang
    • 12
  • Xiao-Lan Zhang
    • 13
  1. 1.Shanghai Institute for Pediatric ResearchXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.The Second Affiliated Hospital of China Medical UniversityShenyangLiaoning Province, China
  3. 3.Peking University First HospitalBeijingChina
  4. 4.West China Second University Hospital, Sichuan UniversityChengduSichuan Province, China
  5. 5.Xiangya Hospital of Central South UniversityChangshaHunan Province, China
  6. 6.Jinan Women & Children HospitalJinanShandong Province, China
  7. 7.Hunan Children’s HospitalChangshaHunan Province, China
  8. 8.Shenzhen Children’s HospitalShenzhenGuangdong Province, China
  9. 9.Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  10. 10.Shenzhen City People’s Hospital, the Second Affiliated Hospital of Jinan University Medical CollegeShenzhenGuangdong Province, China
  11. 11.Ulumuqi Women & Children HospitalUlumuqiXinjiang Uyghur Autonomous Region, China
  12. 12.Shenyang Women HospitalShenyangLiaoning Province, China
  13. 13.Shenzhen Maternity and Child Healthcare HospitalShenzhenGuangdong Province, China

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