World Journal of Pediatrics

, Volume 6, Issue 2, pp 158–162

Continuous renal replacement therapy for patients with acute kidney injury caused by melamine-related urolithiasis

  • Yang Zi-Hao
  • Zhang Chen-Mei
  • Liu Tao
  • Lou Xiao-Fang
  • Chen Zhen-Jie
  • Ye Sheng
Original Article

Abstract

Background

In 2008 there was an epidemic of renal disease affecting infants after consumption of melaminetainted milk products. Most of the infected children were asymptomatic or with mild symptoms, and a few suffered from acute obstructive kidney injury secondary to melamine-contained renal stones (8 of 15 577 children screened at our hospital for urolithiasis). This study was intended to retrospectively review the management of acute kidney injury using continuous renal replacement therapy (CRRT) in the 8 children with acute kidney injury.

Methods

The 8 infants with acute kidney injury caused by melamine-related urolithiasis were referred to the pediatric intensive care unit at the hospital in late 2008. CRRT was given to treat their kidney injuries. Medical records of the infants were reviewed for demographic features, diagnosis, CRRT treatment, and outcomes.

Results

Before CRRT, hypertension was found in 6 of the 8 children. Varying degrees of oliguria, anuria, elevated levels of blood urea nitrogen (BUN) (13.11–35.6 mmol/L) and creatinine (Cr) (238.8–773.7 μmol/L) were observed in these patients. After CRRT, the levels of BUN, Cr and electrolytes decreased. Urine output and edema were improved clinically.

Conclusion

CRRT can rapidly improve renal function, avoiding such surgical interventions as lithotripsy, percutaneous nephrolithotomy, and ureteroscopy. It is an efficient modality to treat acute kidney injury caused by melamine-related urolithiasis.

Key words

acute kidney injury continuous renal replacement therapy infant formula melamine urolithiasis 

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Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Yang Zi-Hao
    • 1
  • Zhang Chen-Mei
    • 1
  • Liu Tao
    • 1
  • Lou Xiao-Fang
    • 1
  • Chen Zhen-Jie
    • 1
  • Ye Sheng
    • 1
    • 2
  1. 1.Department of Pediatric ICUChildren’s Hospital of Zhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina
  2. 2.Department of Pediatric ICUChildren’s Hospital of Zhejiang University School of MedicineHangzhouChina

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