Bacteremia in children at the University Hospital in Riyadh, Saudi Arabia
- 83 Downloads
- 1 Citations
Abstract
Background
Bacteremia is a major pediatric health care problem despite the availability of new modalities in the management of this disease. The aim of the present study was to determine the incidence and pattern of bacteremia in pediatric group at a tertiary hospital in Riyadh, Saudi Arabia.
Methods
This retrospective study was conducted at the Department of Pediatrics, College of Medicine, King Khalid University Hospital, Riyadh in the period of January 2003 to January 2005. Positive culture was found in 259 patients aged below 15 years with a total of 8244 admissions in the period.
Results
The highest incidence of bacteremia was found in patients aged less than 1 year (57.9%), and the majority of patients (30.5%) were infants aged less than 1 month. Staphylococcus aureus was the most common isolated pathogen (18.7%). Prematurity was associated with 13.2% of the cases, and respiratory tract infection (10.1%) and fever (76.1%) were chief complaints.
Conclusions
Staphylococcus aureus is the most common isolated pathogen. The most common primary infections are respiratory tract infection and septic meningitis. Klebsiella pneumoniae and E. coli are the most common isolated Gram-negative organisms.
Key words
bacteremia incidence Staphylococcus aureusPreview
Unable to display preview. Download preview PDF.
References
- 1.Wald ER, Minkowski JM. Bacteremia in childhood. South Med J 1980;70:904–905.Google Scholar
- 2.Wenzel RP, Pinsky MR, Ulevitch RJ, Young L. Current understanding of sepsis. Clin Infect Dis 1996;22:407–412.PubMedGoogle Scholar
- 3.Wheeler AP, Bernard GR. Treating patient with severe sepsis. N Engl J Med 1999;340:207–214.PubMedCrossRefGoogle Scholar
- 4.Gill J, Kumar R, Todd J, Wiskin C. Methicillin-resistance Staphylocicus aureus: awareness and perceptions. J Hosp Infect 2006;62:330–337.CrossRefGoogle Scholar
- 5.Blomberg B, Manji KP, Urassa WK, Tamim BS, Mwakagile DS, Jureen R, et al. Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis 2007;7:43.PubMedCrossRefGoogle Scholar
- 6.Orrett FA, Changoor E. Bacteremia in children at a regional hospital in Trinidad. Int J Infect Dis 2007;11:145–151.PubMedCrossRefGoogle Scholar
- 7.Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y. Comparision of mortality associate with Methcillin suscipitable Staphylococcus aureus bacteremia: a meta analysis. Clin Infect Dis 2003;36:53–59.PubMedCrossRefGoogle Scholar
- 8.Weinstein MP, Mirrett S, Reimer LG, Wilson ML, Smith-Elekes S, Chuard CR, et al. Controlled evaluation of BacT/Alert standard aerobic and FAN aerobic blood culture bottles for detection of bacteremia and fungemia. J Clin Microbiol 1995;33:978–981.PubMedGoogle Scholar
- 9.Weinstein MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997;24:584–602.PubMedGoogle Scholar
- 10.Nimri LF, Rawashdeh M, Meqdam MM. Bacteremia in children: etiologic agents, focal sites, and risk factors. J Trop Pediatr 2001;47:356–360.PubMedCrossRefGoogle Scholar
- 11.Emori TG, Gaynes RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev 1993;6:428–442.PubMedGoogle Scholar
- 12.Haddon RA, Barnett PL, Grimwood K, Hogg GG. Bacteremia in febrile children presenting to a pediatric emergency department. Med J Aust 1999;170:475–478.PubMedGoogle Scholar
- 13.Moses AE, Beeri M, Engelhard D. Group A streptococcal meningitis: report of two cases. J Infect 1998:36:116–118.PubMedCrossRefGoogle Scholar
- 14.Kloos WE, Bannerman TL. Update on clinical significance of coagulase-negative staphylococci. Clin Microbiol Rev 1994;7:117–140.PubMedGoogle Scholar
- 15.Hussain QS, Khalil SH, Johnson S, Flourney DJ. Etiology of bacteremia in a referral hospital in Saudi Arabia. Ann Saudi Med 1987;7:51–55.Google Scholar
- 16.Wendt C, Messer SA, Hollis RJ, Pfaller MA, Herwaldt LA. Epidemiology of polyclonal gram-negative bacteremia. Diagn Microbiol Infect Dis 1998;32:9–13.PubMedCrossRefGoogle Scholar
- 17.Anthony RM, Brown TJ, French GL. Rapid diagnosis of bacteremia by universal amplification of 23S ribosomal DNA followed by hybridization to an oligonucleotide array. J Clin Microbiol 2000;38:781–788.PubMedGoogle Scholar
- 18.Lee HJ. Epidemiology of systemic hemophilus influenzae disease in Korean children. Pediatr Infect Dis J 1998;17(Suppl 9):S185–189.PubMedCrossRefGoogle Scholar
- 19.Abdullah AM, Chowdhury MN, al Mazrou A, Al-Zamil F, Peds AB, Kambal AM. Spectrum of Haemophilus influenzae type b disease in children at a university hospital in Riyadh, Saudi Arabia. J Trop Pediatr 1997;43:10–12.PubMedCrossRefGoogle Scholar
- 20.Babay HA, Twum-Danso K, Kambal AM, Al-Otaibi FE. Bloodstreem infections in pediatric patients. Saudi Med J 2005;26:1555–1561.PubMedGoogle Scholar
- 21.Silverstein M, Bachur R, Harper MB. Clinical implications of penicillin and ceftriaxone resistance among children with pneumococcal bacteremia. Pediatr Infect Dis J 1999;18:35–41.PubMedCrossRefGoogle Scholar
- 22.Totapally BR, Walsh WT. Pneumococcal bacteremia in childhood: a 6-year experience in a community hospital. Chest 1999;113:1207–1214.CrossRefGoogle Scholar