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Netherlands Heart Journal

, Volume 21, Issue 4, pp 173–174 | Cite as

Postmenopausal sex hormones: comparing apples and pears

  • Y. AppelmanEmail author
  • C. B. Lambalk
Editorial Comment

The sex hormone story in relation to cardiovascular disease is always good for a surprise. Where we assumed that increased levels of female sex hormones were protective against the development of cardiovascular disease, our colleagues Mei Dong et al. from Yantai, China suggest quite the opposite. In their paper published in this edition of the Netherlands Heart Journal the authors describe a relation between the occurrence of a myocardial infarction (MI) in post-menopausal women and levels of sex hormones [1]. They report that high levels of oestradiol and increased waist-to-hip ratio (WHR) are related to the occurrence of acute MI.

This story is confusing. From an epidemiological perspective it was shown that in women there is a relation between the onset of the menopause and the risk of MI. Based on these observations studies were initiated to supply sex hormones in order to postpone the onset of atherosclerosis. Yet the beneficial effects of hormone replacement therapy were off set...

Notes

Funding

None.

Conflict of interests

None declared.

References

  1. 1.
    Dong M, Gou F, Yang J, et al. Detrimental effects of endogenous estrogens on primary acute myocardial infarction among postmenopausal women. Neth Heart J. 2012. doi: 10.1007/s12471-012-0323-5 [Epub ahead of print].
  2. 2.
    Grady D, Herrington D, Bittner V, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA. 2002;1:49–57.CrossRefGoogle Scholar
  3. 3.
    Schierbeck L, Rejnmark L, Tofteng C, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012;345:e6409. doi: 10.1136/bmj.e6409.CrossRefGoogle Scholar
  4. 4.
    Liedtke S, Schmidt ME, Vrieling A, et al. Postmenopausal sex hormones in relation to body fat distribution. Obesity. 2012;20:1088–95. doi: 10.1038/oby.2011.383. Epub 2012 Jan 12.CrossRefGoogle Scholar
  5. 5.
    He H, Yang F, Liu X, et al. Sex hormone ration changes in men and postmenopausal women with coronary artery disease. Menopause. 2007;14:385–90.CrossRefGoogle Scholar
  6. 6.
    Batrinos ML, Panitsa-Faflia C, Koutsoumanis C, et al. Surgical stress induces a marked and sustained increase of adrenal androgen secretion in postmenopausal women. In Vivo. 1999;13:147–50.PubMedGoogle Scholar
  7. 7.
    Fritz and Speroff in Clinical Gynecologica Endocrinology and Infertility, 8th edition, Wolter Kluwer, Lippincott Williams and Wilkins, 2012 page 706Google Scholar
  8. 8.
    Gooren LJ, Giltay EJ, Bunck MC. Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience. JCEM. 2008;93:19–25.PubMedGoogle Scholar
  9. 9.
    Muraleedharan V, Jones H. Testosterone and the metabolic syndrome. Ther Adv Endocrinol Metab. 2010;1:207–23.CrossRefGoogle Scholar
  10. 10.
    Maas AHEM, Appelman YEA. Gender differences in coronary heart disease. Neth Heart J. 2010;18:598–602.CrossRefGoogle Scholar

Copyright information

© The Author(s) 2013

Authors and Affiliations

  1. 1.Department of Cardiology 5F020VU University Medical CenterAmsterdamthe Netherlands
  2. 2.Department of Obstretics, Gynecology and Reproductive MedicineVU University Medical CenterAmsterdamthe Netherlands

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