Netherlands Heart Journal

, Volume 21, Issue 4, pp 166–172 | Cite as

Cardiopulmonary interactions during mechanical ventilation in critically ill patients

  • T. G. V. CherpanathEmail author
  • W. K. Lagrand
  • M. J. Schultz
  • A. B. J. Groeneveld
Review Article


Cardiopulmonary interactions induced by mechanical ventilation are complex and only partly understood. Applied tidal volumes and/or airway pressures largely mediate changes in right ventricular preload and afterload. Effects on left ventricular function are mostly secondary to changes in right ventricular loading conditions. It is imperative to dissect the several causes of haemodynamic compromise during mechanical ventilation as undiagnosed ventricular dysfunction may contribute to morbidity and mortality.


Mechanical ventilation Preload Afterload Positive pressure ventilation Cardiopulmonary interaction 



We would like to thank Carolien Paes for her assistance with the figure preparations


No conflicts of interest, financial or otherwise, are declared by the authors.


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Copyright information

© The Author(s) 2013

Authors and Affiliations

  • T. G. V. Cherpanath
    • 1
    Email author
  • W. K. Lagrand
    • 1
  • M. J. Schultz
    • 2
  • A. B. J. Groeneveld
    • 3
  1. 1.Department of Intensive Care Medicine, Academic Medical CentreUniversity of AmsterdamAmsterdamthe Netherlands
  2. 2.Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical CentreUniversity of AmsterdamAmsterdamthe Netherlands
  3. 3.Department of Intensive Care MedicineErasmus Medical CentreRotterdamthe Netherlands

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