Netherlands Heart Journal

, Volume 20, Issue 10, pp 419–424 | Cite as

Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study

  • H. G. Freling
  • Y. J. van Slooten
  • J. P. van Melle
  • B. J. M. Mulder
  • A. P. J. van Dijk
  • H. L. Hillege
  • M. C. Post
  • G. Tj. Sieswerda
  • M. R. M. Jongbloed
  • T. P. Willems
  • P. G. PieperEmail author
  • On behalf of the PROSTAVA investigators
Special Article – E-learning



Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied.


The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch.


The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP).


Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.


Congenital heart disease Prosthesis-patient mismatch Prosthetic heart valve Valvular heart disease Functional outcome Quality of life 


Financial support

This study is supported by a grant from the Netherlands Heart Foundation to P.G.P. (2009B013).


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Copyright information

© Springer Media / Bohn Stafleu van Loghum 2012

Authors and Affiliations

  • H. G. Freling
    • 1
    • 2
    • 10
  • Y. J. van Slooten
    • 1
    • 3
    • 10
  • J. P. van Melle
    • 1
  • B. J. M. Mulder
    • 5
  • A. P. J. van Dijk
    • 6
  • H. L. Hillege
    • 4
  • M. C. Post
    • 7
  • G. Tj. Sieswerda
    • 8
  • M. R. M. Jongbloed
    • 9
  • T. P. Willems
    • 2
  • P. G. Pieper
    • 1
    Email author
  • On behalf of the PROSTAVA investigators
  1. 1.Department of CardiologyUniversity of Groningen, University Medical Center GroningenGroningenthe Netherlands
  2. 2.Departments of RadiologyUniversity of Groningen, University Medical Center GroningenGroningenthe Netherlands
  3. 3.Departments of Cardiothoracic SurgeryUniversity of Groningen, University Medical Center GroningenGroningenthe Netherlands
  4. 4.Departments of EpidemiologyUniversity of Groningen, University Medical Center GroningenGroningenthe Netherlands
  5. 5.Department of CardiologyAcademic Medical Centre, University of AmsterdamAmsterdamthe Netherlands
  6. 6.Department of CardiologyUniversity Medical Center Nijmegen St. Radboud, Radboud University NijmegenNijmegenthe Netherlands
  7. 7.Department of CardiologySt. Antonius HospitalNieuwegeinthe Netherlands
  8. 8.Department of CardiologyUniversity Medical Centre UtrechtUtrechtthe Netherlands
  9. 9.Department of CardiologyLeiden University Medical Center, University of LeidenLeidenthe Netherlands
  10. 10.Interuniversity Cardiology Institute of the Netherlands (ICIN)Utrechtthe Netherlands

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