Netherlands Heart Journal

, Volume 20, Issue 10, pp 410–418

CT fractional flow reserve: the next level in non-invasive cardiac imaging

  • M. F. L. Meijs
  • M. J. Cramer
  • H. El Aidi
  • P. A. Doevendans
Review Article


The haemodynamic effect of a coronary artery stenosis is a better predictor of prognosis than anatomical lumen obstruction. Until recently, no individual non-invasive test could provide both accurate coronary anatomy and lesion-specific myocardial ischaemia. However, computer tomography (CT) fractional flow reserve, which can be calculated from a standard CT coronary angiogram, was recently demonstrated to accurately detect and rule out the haemodynamic significance of individual coronary artery stenoses.


CT coronary angiography Fractional flow reserve (FFR) Non-invasive cardiac imaging Single photon emission computed tomography (SPECT) Positron emission tomography (PET) Myocardial perfusion imaging 


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Copyright information

© Springer Media / Bohn Stafleu van Loghum 2012

Authors and Affiliations

  • M. F. L. Meijs
    • 1
  • M. J. Cramer
    • 1
  • H. El Aidi
    • 1
  • P. A. Doevendans
    • 1
  1. 1.Department of CardiologyUniversity Medical Centre UtrechtUtrechtthe Netherlands

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