Netherlands Heart Journal

, Volume 20, Issue 9, pp 347–353 | Cite as

Treatment of non-culprit lesions detected during primary PCI: long-term follow-up of a randomised clinical trial

  • A. Ghani
  • J-H. E. Dambrink
  • A. W. J. van ’t Hof
  • J. P. Ottervanger
  • A. T. M. Gosselink
  • J. C. A. Hoorntje
Original article



There are conflicting data regarding optimal treatment of non-culprit lesions detected during primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) and multi-vessel disease (MVD). We aimed to investigate whether ischaemia-driven early invasive treatment improves the long-term outcome and prevents major adverse cardiac events (MACE).


121 patients with at least one non-culprit lesion were randomised in a 2:1 manner, 80 were randomised to early fractional flow reserve (FFR)-guided PCI (invasive group), and 41 to medical treatment (conservative group). The primary endpoint was MACE at 3 years.


Three-year follow-up was available in 119 patients (98.3 %). There was no significant difference in all-cause mortality between the invasive and conservative strategy, 4 patients (3.4 %) died, all in the invasive group (P = 0.29). Re-infarction occurred in 14 patients (11.8 %) in the invasive group versus none in the conservative group (p = 0.002). Re-PCI was performed in 7 patients (8.9 %) in the invasive group and in 13 patients (32.5 %) in the conservative group (P = 0.001). There was no difference in MACE between these two strategies (35.4 vs 35.0 %, p = 0.96).


In STEMI patients with MVD, early FFR-guided additional revascularisation of the non-culprit lesion did not reduce MACE at three-year follow-up compared with a more conservative strategy. The rate of MACE in the invasive group was predominantly driven by death and re-infarction, whereas in the conservative group the rate of MACE was only driven by repeat interventions.


Acute myocardial infarction Multi-vessel disease Primary percutaneous coronary intervention Multi-vessel angioplasty Long-term follow-up Medical therapy 


Conflict of interest

No conflict of interest, no funding


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Copyright information

© Springer Media / Bohn Stafleu van Loghum 2012

Authors and Affiliations

  • A. Ghani
    • 1
  • J-H. E. Dambrink
    • 1
  • A. W. J. van ’t Hof
    • 1
  • J. P. Ottervanger
    • 1
  • A. T. M. Gosselink
    • 1
  • J. C. A. Hoorntje
    • 1
  1. 1.Department of CardiologyIsala kliniekenZwollethe Netherlands

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