PS13 - 66. The type 1 diabetes associated HLA-DQ8-transdimer accommodates a unique islet peptide repertoire
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Abstract
In spite of the promise of decades of genetic research and the recently hyped expectations following genome-wide association studies in T1D, it remains unknown why HLADQ2 and HLA-DQ8 are strongly predisposing haplotypes for T1D. We understand even less why HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared to HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a transdimer formed between the α-chain of HLA-DQ2 (DQA1*0501) and the β-chain of HLA-DQ8 (DQB1*0302) that may bind and present unique autoantigen derived diabetogenic epitopes.
Keywords
Peptide Binding Assay Binding Motif Genetic Research Peptide Binding
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© Bohn Stafleu van Loghum 2011