Recent Advances in the Field of Optical Coherence Tomography

Intravascular Imaging (IK Jang, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Intravascular Imaging


Purpose of Review

The scope of this text is to critically review the most important recent advances in the field of optical coherence tomography, both from a clinical, scientific, and technical point of view.

Recent Findings

In recent years, important steps forward have been put in the field of optimization of PCI (with a focus on optimal sizing of stents and optimization of stent expansion after implantation) and the differentiation and its possible applications of various underlying morphologic characteristics of acute coronary syndrome lesions. Several efforts have been made to elucidate underlying mechanical causes of stent thrombosis, based on optical coherence tomography (OCT) imaging. This had led to the recognition of neoatherosclerosis as an important cause for very late stent thrombosis, fueling new research into this area and to the development of intracoronary devices which could be even more safe for patients on the very long term.


With an ever increasing use for clinical and scientific applications in coronary artery disease, OCT has come to a mature and solid tool in the armamentarium of the coronary artery disease specialist. With new areas deserving more intensified focus and several innovations ahead, it seems that OCT is there to defend its position as the standard intracoronary imaging modality for the next decennium.


Optical coherence tomography Acute coronary syndrome Stent thrombosis In-stent restenosis DAPT Bioresorbable vascular scaffold Plaque erosion Thin-cap fibroatheroma 



Bare metal stent


Bioresorbable vascular scaffold


Acute coronary syndrome


Dual antiplatelet therapy


Drug-eluting stent


External elastic lamina


In-stent restenosis


Intra-vascular ultra sound


Low-density lipoprotein


Major adverse cardiovascular events


Optical coherence tomography


Percutaneous coronary intervention


Proprotein convertase subtilisin/kexin type 9


Stent thrombosis


ST segment elevation myocardial infarction


Thin-cap fibro atheroma


Very late stent thrombosis


Compliance with Ethical Standards

Conflict of Interest

Giovanni J. Ughi declares that he has no conflict of interest.

Tom Adriaenssens reports consultancy fees from Abbott SJ Medical.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Cardiovascular Sciences, Catholic University Leuven and Department of Cardiovascular MedicineUniversity HospitalsLeuvenBelgium

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