Novel Approaches to Myocardial Perfusion: 3D First-Pass CMR Perfusion Imaging and Oxygenation-Sensitive CMR

  • Dominik P. Guensch
  • Matthias G. FriedrichEmail author
Cardiac Magnetic Resonance (E Nagel and V Puntmann, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cardiac Magnetic Resonance


This article reviews technical aspects and the current status of novel cardiovascular magnetic resonance (CMR) approaches to assessing myocardial perfusion, specifically oxygenation-sensitive magnetic resonance imaging, comparing their diagnostic targets and clinical role with those of other imaging approaches. The paper includes discussions of relevant pathophysiological aspects of myocardial ischemia and the clinical context of revascularization in patients with suspected or known coronary artery disease. Research using oxygenation-sensitive CMR may play an important role for a better understanding of the interplay of coronary artery stenosis, blood flow reduction, and their impact on actual myocardial ischemia.


Cardiovascular magnetic resonance Oxygenation-sensitive MR Myocardial perfusion imaging Myocardial ischemia Coronary artery disease BOLD MRI 


Compliance with Ethics Guidelines

Conflict of Interest

M. G. Friedrich is board member, advisor, and shareholder of Circle Cardiovascular Imaging Inc., the manufacturer of cvi42, a cardiovascular MR postprocessing and evaluation software. D. P. Guensch and M. G. Friedrich have a pending patent (US Patent Pending 61_680,981) on the use of breathing maneuvers for diagnosing heart disease.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Dominik P. Guensch
    • 1
    • 2
  • Matthias G. Friedrich
    • 3
    • 4
    • 5
    Email author
  1. 1.Department of Anaesthesiology and Pain MedicineBern University HospitalBernSwitzerland
  2. 2.Departments of CardiologyUniversité de MontréalMontréalCanada
  3. 3.Philippa and Marvin Carsley CMR Centre at the Montreal Heart InstituteMontréalCanada
  4. 4.Departments of Cardiology and RadiologyUniversité de MontréalMontréalCanada
  5. 5.Departments of Cardiac Sciences and RadiologyUniversity of CalgaryCalgaryCanada

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