Assessing Myocardial Disease Using T1ρ MRI
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There is great interest to use magnetic resonance imaging (MRI) for non-invasive assessment of myocardial disease in ischemic and non-ischemic cardiomyopathies. Recently, there has been a renewed interest to use a magnetic resonance imaging (MRI) technique utilizing spin locking radiofrequency (RF) pulses, called T1ρ MRI. The spin locking RF pulse creates sensitivity to some mechanisms of nuclear relaxation such as 1H exchange between water and amide, amine and hydroxyl functional groups in molecules; consequently, there is the potential to non-invasively, and without exogenous contrast agents, obtain important molecular information from diseased myocardial tissue. The purpose of this article is to review and critically examine the recent published literature in the field related to T1ρ MRI of myocardial disease.
KeywordsIschemic Non-ischemic Heart disease Magnetic resonance imaging T1ρ relaxation Spin lock radiofrequency pulse
The authors thank Dr. Ravinder Reddy for reviewing this work and providing valuable insight and expertise.
Conflict of Interest
Yuchi Han, Timo Liimatainen, Robert C Gorman, Walter RT Witschey declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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