Assessing Myocardial Disease Using T MRI

  • Yuchi Han
  • Timo Liimatainen
  • Robert C. Gorman
  • Walter R. T. Witschey
Molecular Imaging (G Strijkers, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Molecular Imaging


There is great interest to use magnetic resonance imaging (MRI) for non-invasive assessment of myocardial disease in ischemic and non-ischemic cardiomyopathies. Recently, there has been a renewed interest to use a magnetic resonance imaging (MRI) technique utilizing spin locking radiofrequency (RF) pulses, called T MRI. The spin locking RF pulse creates sensitivity to some mechanisms of nuclear relaxation such as 1H exchange between water and amide, amine and hydroxyl functional groups in molecules; consequently, there is the potential to non-invasively, and without exogenous contrast agents, obtain important molecular information from diseased myocardial tissue. The purpose of this article is to review and critically examine the recent published literature in the field related to T MRI of myocardial disease.


Ischemic Non-ischemic Heart disease Magnetic resonance imaging T relaxation Spin lock radiofrequency pulse 



The authors thank Dr. Ravinder Reddy for reviewing this work and providing valuable insight and expertise.

Conflict of Interest

Yuchi Han, Timo Liimatainen, Robert C Gorman, Walter RT Witschey declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yuchi Han
    • 3
  • Timo Liimatainen
    • 2
  • Robert C. Gorman
    • 1
  • Walter R. T. Witschey
    • 1
  1. 1.Department of Radiology, Perelman School of MedicineUniversity of Pennsylvania, Smilow Center for Translational ResearchPhiladelphiaUSA
  2. 2.Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular SciencesUniversity of Eastern FinlandKuopioFinland
  3. 3.Cardiovascular Division, Department of MedicinePerelman School of Medicine, Hospital of the University of PennsylvaniaPhiladelphiaUSA

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