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The Disease Burden of Dietary Exposure to Inorganic Arsenic in Denmark, 2018

  • Lea S. JakobsenEmail author
  • Freja A. Fabricius
  • Janna Nissen
  • Tue Christensen
  • Rikke Andersen
  • Morten Poulsen
  • Sara M. Pires
Original Paper

Abstract

Arsenic is a naturally occurring metalloid in soil, air, water and food in organic and inorganic forms. Several epidemiological studies have shown that inorganic arsenic (i-As) is carcinogenic to humans. Previous studies have raised concern about dietary i-As exposure from various sources, including brown rice. We estimated the burden of disease in terms of disability-adjusted life years (DALY) of lung, bladder and skin cancer caused by dietary exposure to i-As in Denmark. Moreover, we investigated the impact of different rice-consumption scenarios of white and brown rice. We combined exposure assessment with dose response relationships of i-As exposure and lifetime risk of each cancer type to estimate the annual incidence due to i-As exposure. Associated DALY was calculated based on national health statistics. We estimated 0.57 extra cancer cases and 4.5 DALY [95% UI 4.2–4.8] in the Danish population in 2018. Even though rice was found not to be the main contributor of i-As, substitution of white and parboiled rice by brown rice resulted in a 32.7% increase in DALY compared to the current consumption of rice. The estimated number of cancer cases due to dietary i-As equals 0.006% of the annual incidence of the three cancer types in Denmark. Our estimates exclude exposure to i-As from drinking water and other beverages, which should be accounted for in future estimates. Our study highlights the need for deriving national-specific estimates of food borne disease burden to allow for comparison and prioritization.

Keywords

Inorganic arsenic Dietary exposure Cancer Disease burden DALY 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Electronic supplementary material 1 (PDF 8 kb)
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Electronic supplementary material 2 (PDF 113 kb)
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Electronic supplementary material 3 (PDF 10 kb)
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Electronic supplementary material 4 (PDF 81 kb)
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Electronic supplementary material 5 (PDF 106 kb)

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Division for Diet, Diease Prevention and ToxicologyTechnical University of DenmarkKgs. LyngbyDenmark
  2. 2.Division of Risk Assessment and NutritionKgs. LyngbyDenmark

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