Managing Emerging Contaminants: Status, Impacts, and Watershed-Wide Strategies
- 360 Downloads
- 7 Citations
Abstract
Widespread occurrence of emerging contaminants (ECs) in water bodies is a major health concern worldwide, both in developing and developed countries. Contaminants from pharmaceutical, personal care products, pest control, and animal operations enter water bodies and can exceed acceptable levels. ECs can cause harmful impacts on aquatic and terrestrial wildlife and human communities. Endocrine disrupting chemicals cause a number of reproductive and sexual abnormalities in wildlife and humans. During prenatal and/or early postnatal life, exposure to these chemicals can impair the development of the endocrine system and of the organs that respond to endocrine signals in organisms. The effects during development are permanent and sometimes irreversible. Managing ECs in water resources is a critical issue that requires attention especially in sensitive ecosystems and in rapidly developing areas. There is a need for a comprehensive framework that aims at system-wide abatement (source-transfer-fate levels) using both structural and non-structural approaches. In this study, we review the state of this problem in developing and developed countries, nature of their impacts on aquatic organisms, terrestrial animals, and on public health. A comprehensive, innovative, and novel approach with multi-level strategies at source, transfer, and sink level is proposed for effective removal of ECs. Some structural approaches at source level for abatement of ECs include the use of best management practices like buffer strips, riparian management, natural, and constructed wetlands. Since these strategies have multi-level applicability, they are cost-effective alternatives to include in wastewater treatment. Among structural approaches at sink level, powdered activated carbon, nanofiltration, and reverse osmosis can remove most of the emerging organic. However, the cost of treatment by these methods is high and it is inevitable for treating drinking water. Besides structural approaches, non-structural approaches play a major role and need to use targeted strategies in dissemination of information, outreach to modify human behavior, incentives for controlling contaminant loads, and improved and updated policy mechanism for compliance to pollutant standards.
Keywords
Emerging contaminants Impacts WatershedsReferences
- 3M Company (1999) Fluorochemical use, distribution, and release overview. Report Prepared for the US EPA 1 March 2000: EPA Docket no. OPPT-2002-0043. 3M Company, St. Paul, MNGoogle Scholar
- Aggazzotti G, Fantuzzi G, Righi E, Predieri G (1998) Blood and breath analyses as biological indicators of exposure to trihalomethanes in indoor swimming pools. Sci Total Environ 217(1):155–163CrossRefGoogle Scholar
- Anastas PT, Warner JC (2000) Green chemistry: theory and practice. Oxford University Press, New YorkGoogle Scholar
- Andreozzi R, Campanella L, Fraysse B, Garric J, Gonnella A, Lo Giudice R, Marotta R, Pinto G, Pollio A (2004) Effects of advanced oxidation processes (AOPs) on the toxicity of a mixture of pharmaceuticals. Water Sci Technol 50(5):23–28Google Scholar
- Angier JT, McCarty GW, Rice CP, Bialek K (2002) Influence of a riparian wetland on nitrate and herbicides exported from an agricultural field. J Agric Food Chem 50(15):4424–4429CrossRefGoogle Scholar
- Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR (2007) Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect 1:1670–1676CrossRefGoogle Scholar
- Arinaitwe K, Muir DC, Kiremire BT, Fellin P, Li H, Teixeira C (2014) Polybrominated diphenyl ethers and alternative flame-retardants in air and precipitation samples from the northern Lake Victoria region, east Africa. Environ Sci Technol 48(3):1458–1466CrossRefGoogle Scholar
- Bishop CA, Ng P, Pettit K, Kennedy S, Stegeman J, Norstrom R, Brooks R (1998) Environmental contamination and developmental abnormalities in eggs and hatchlings of the common snapping turtle (Chelydra serpentina serpentina ) from the Great Lakes—St Lawrence River basin (1989–1991). Environ Pollut 101(1):143–156CrossRefGoogle Scholar
- Bolong N, Ismail A, Salim MR, Matsuura T (2009) A review of the effects of emerging contaminants in wastewater and options for their removal. Desalination 239(1):229–246CrossRefGoogle Scholar
- Bonde JP (2010) Male reproductive organs are at risk from environmental hazards. Asian J Androl 12(2):152–156CrossRefGoogle Scholar
- Bronaugh R, Yourick J, Havery D (1998) Dermal exposure assessment for the fragrance musk xylol. Abstract No 274. In: Proceedings of the society of toxicology 1998 annual meetingGoogle Scholar
- Carlsson C, Johansson A, Alvan G, Bergman K, Kühler T (2006) Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients. Sci Total Environ 364(1):67–87CrossRefGoogle Scholar
- Centner TJ, Houston JE, Keeler AG, Fuchs C (1999) The adoption of best management practices to reduce agricultural water contamination. Limnologica 29(3):366–373CrossRefGoogle Scholar
- Clara M, Strenn B, Gans O, Martinez E, Kreuzinger N, Kroiss H (2005) Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Res 39(19):4797–4807CrossRefGoogle Scholar
- Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107(Suppl 6):907–938CrossRefGoogle Scholar
- Desbrow C, Routledge E, Brighty G, Sumpter J, Waldock M (1998) Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ Sci Technol 32(11):1549–1558CrossRefGoogle Scholar
- Dodds EC, Lawson W (1938) Molecular structure in relation to oestrogenic activity. Compounds without a Phenanthrene Nucleus. Proc R Soc Lond 125(839):222–232CrossRefGoogle Scholar
- Dorne JL, Doerge DR, Vandenbroeck M, Fink-Gremmels J, Mennes W, Knutsen HK, Vernazza F, Castle L, Edler L, Benford D (2013) Recent advances in the risk assessment of melamine and cyanuric acid in animal feed. Toxicol Appl Pharmacol 270(3):218–229CrossRefGoogle Scholar
- Fewless KL, Sharvelle S, Roesner LA (2011) Source separation and treatment of anthropogenic urine. WERF, LondonGoogle Scholar
- Fox GA (2001) Effects of endocrine disrupting chemicals on wildlife in Canada: past, present and future. Water Qual Res J Can 36(3):233–251Google Scholar
- Fuentes S, Colomina MT, Vicens P, Franco-Pons N, Domingo JL (2007) Concurrent exposure to perfluorooctane sulfonate and restraint stress during pregnancy in mice: effects on postnatal development and behavior of the offspring. Toxicol Sci 98(2):589–598CrossRefGoogle Scholar
- Gross B, Montgomery-Brown J, Naumann A, Reinhard M (2004) Occurrence and fate of pharmaceuticals and alkylphenol ethoxylate metabolites in an effluent-dominated river and wetland. Environ Toxicol Chem 23(9):2074–2083CrossRefGoogle Scholar
- Guillette LJ Jr, Gross TS, Masson GR, Matter JM, Percival HF, Woodward AR (1994) Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect 102(8):680–688CrossRefGoogle Scholar
- Gupta P (2004) Pesticide exposure—Indian scene. Toxicology 198(1):83–90CrossRefGoogle Scholar
- Heberer T, Fuhrmann B, Schmidt-Baumler K, Tsipi D, Koutsouba V, Hiskia A (2001) Occurrence of pharmaceutical residues in sewage, river, ground and drinking water in Greece and Berlin (Germany). In: Daughton CG, Jones-Lepp TL (eds) Pharmaceuticals and personal care products in the environment: scientific and regulatory issues. American Chemical Society, Washington, pp 70–83CrossRefGoogle Scholar
- Henderson WM, Smith MA (2007) Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol. Toxicol Sci 95:452–461CrossRefGoogle Scholar
- Henny C, Grove R, Hedstrom O (1996) A field evaluation of mink and river otter on the lower Columbia River and the influence of environmental contaminants. Final Report to the Lower Columbia River Bi-State Water Quality Program (Portland, OR). National Biological Service, Forest and Rangeland Ecosystem Science Center, Corvallis, ORGoogle Scholar
- Hoeger B, Köllner B, Dietrich DR, Hitzfeld B (2005) Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat Toxicol 75(1):53–64CrossRefGoogle Scholar
- Hu J, Aizawa T, Ookubo S (2002) Products of aqueous chlorination of bisphenol A and their estrogenic activity. Environ Sci Technol 36(9):1980–1987CrossRefGoogle Scholar
- Huber MM, Canonica S, Park G, Von Gunten U (2003) Oxidation of pharmaceuticals during ozonation and advanced oxidation processes. Environ Sci Technol 37(5):1016–1024CrossRefGoogle Scholar
- IARC (1991) Chlorinated drinking water. In: Chlorinated drinking water; chlorination by products; some other halogenated compounds; cobalt and cobalt compounds. International Agency for Research on Cancer, Lyon (IARC Monographs on the evaluation of the Carcinogenic Risk of Chemicals to Humans, 52:45–141)Google Scholar
- Jacobson JL, Jacobson SW (1997) Evidence for PCBs as neurodevelopmental toxicants in humans. Neurotoxicology 18(2):415–424Google Scholar
- Janák K, Covaci A, Voorspoels S, Becher G (2005) Hexabromocyclododecane in marine species from the Western Scheldt Estuary: diastereoisomer-and enantiomer-specific accumulation. Environ Sci Technol 39(7):1987–1994CrossRefGoogle Scholar
- Jelic A, Gros M, Ginebreda A, Cespedes-Sánchez R, Ventura F, Petrovic M, Barcelo D (2011) Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Res 45(3):1165–1176CrossRefGoogle Scholar
- Jobling S, Sumpter JP, Sheahan D, Osborne JA, Matthiessen P (1996) Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15(2):194–202CrossRefGoogle Scholar
- Johnson AC, Sumpter JP (2001) Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environ Sci Technol 35(24):4697–4703CrossRefGoogle Scholar
- Karlsson H, Muir DC, Teixiera CF, Burniston DA, Strachan WM, Hecky RE, Mwita J, Bootsma HA, Grift NP, Kidd KA (2000) Persistent chlorinated pesticides in air, water, and precipitation from the Lake Malawi area, southern Africa. Environ Sci Technol 34(21):4490–4495CrossRefGoogle Scholar
- Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 43(2):363–380CrossRefGoogle Scholar
- Kavlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaattari S, Lucier G, Luster M, Mac MJ, Maczka C, Miller R, Moore J, Rolland R, Scott G, Sheehan DM, Sinks T, Tilson HA (1996) Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ Health Perspect 104(Suppl 4):715–740CrossRefGoogle Scholar
- Kim SD, Cho J, Kim IS, Vanderford BJ, Snyder SA (2007) Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and wastewaters. Water Res 41(5):1013–1021CrossRefGoogle Scholar
- Kimbrough DE, Parekh P (2007) Occurrence and co-occurrence of perchlorate and nitrate in california drinking water sources. J Am Water Works 99(9):126–132Google Scholar
- Kime D, Nash J (1999) Gamete viability as an indicator of reproductive endocrine disruption in fish. Sci Total Environ 233(1):123–129CrossRefGoogle Scholar
- Kimura K, Toshima S, Amy G, Watanabe Y (2004) Rejection of neutral endocrine disrupting compounds (EDCs) and pharmaceutical active compounds (PhACs) by RO membranes. J Membr Sci 245(1–2):71–78CrossRefGoogle Scholar
- Kiso Y, Sugiura Y, Kitao T, Nishimura K (2001) Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes. J Membr Sci 192(1–2):1–10CrossRefGoogle Scholar
- Klamerth N, Malato S, Agüera A, Fernández-Alba A (2013) Photo-Fenton and modified photo-Fenton at neutral pH for the treatment of emerging contaminants in wastewater treatment plant effluents: a comparison. Water Res 47(2):833–840CrossRefGoogle Scholar
- Kolok AS, Snow DD, Kohno S, Sellin MK, Guillette LJ (2007) Occurrence and biological effect of exogenous steroids in the Elkhorn River, Nebraska. Sci Total Environ 388:104–115CrossRefGoogle Scholar
- Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999–2000: a national reconnaissance. Environ Sci Technol 36(6):1202–1211CrossRefGoogle Scholar
- Kolpin DW, Skopec M, Meyer MT, Furlong ET, Zaugg SD (2004) Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Sci Total Environ 328(1):119–130CrossRefGoogle Scholar
- Koren H, Bisesi MS (2002) Handbook of environmental health: biological, chemical, and physical agents of environmentally related disease. CRC Press, Boca RatonGoogle Scholar
- Kosaka K, Asami M, Matsuoka Y, Kamoshita M, Kunikane S (2007) Occurrence of perchlorate in drinking water sources of metropolitan area in Japan. Water Res 41(15):3474–3482CrossRefGoogle Scholar
- Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D (1993) Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132(6):2279–2286Google Scholar
- Kruger EL, Somasundaram L, Coats JR, Kanwar RS (1993) Persistence and degradation of [14C] atrazine and [14C] deisopropylatrazine as affected by soil depth and moisture conditions. Environ Toxicol Chem 12(11):1959–1967CrossRefGoogle Scholar
- Lamm SH, Braverman LE, Li FX, Richman K, Pino S, Howearth G (1999) Thyroid health status of ammonium perchlorate workers: a cross-sectional occupational health study. J Occup Environ Med 41(4):248–260CrossRefGoogle Scholar
- Larsen TA, Gujer W (1997) The concept of sustainable urban water management. Water Sci Technol 35(9):3–10CrossRefGoogle Scholar
- Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, Stevenson LA (2003) Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol Sci 74(2):382–392CrossRefGoogle Scholar
- Lin AY, Yu T, Lin C (2008) Pharmaceutical contamination in residential, industrial, and agricultural waste streams: risk to aqueous environments in Taiwan. Chemosphere 74(1):131–141CrossRefGoogle Scholar
- Lin C, Lerch RN, Goyne KW, Garrett HE (2011) Reducing herbicides and veterinary antibiotics losses from agroecosystems using vegetative buffers. J Environ Qual 40(3):791–799CrossRefGoogle Scholar
- Lindström A, Buerge IJ, Poiger T, Bergqvist P, Müller MD, Buser H (2002) Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater. Environ Sci Technol 36(11):2322–2329CrossRefGoogle Scholar
- Loos R, Carvalho R, António DC, Comero S, Locoro G, Tavazzi S, Paracchini B, Ghiani M, Lettieri T, Blaha L, Jarosova B, Voorspoels S, Servaes K, Haglund P, Fick J, Lindberg RH, Schwesig D, Gawlik BM (2013) EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents. Water Res 47(17):6475–6487CrossRefGoogle Scholar
- Loraine GA, Pettigrove ME (2006) Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in southern California. Environ Sci Technol 40(3):687–695CrossRefGoogle Scholar
- Lyssimachou A, Arukwe A (2007) Alteration of brain and interrenal StAR protein, P450 scc, and Cyp11β mRNA Levels in Atlantic Salmon after nominal waterborne exposure to the synthetic pharmaceutical estrogen ethynylestradiol. J Toxicol Environm Health Part A 70(7):606–613CrossRefGoogle Scholar
- Marklund A, Andersson B, Haglund P (2005) Organophosphorus flame retardants and plasticizers in Swedish sewage treatment plants. Environ Sci Technol 39(19):7423–7429CrossRefGoogle Scholar
- Maruya KA, Dodder NG, Weisberg SB, Gregorio D, Bishop JS, Klosterhaus S, Alvarez DA, Furlong ET, Bricker S, Kimbrough KL, Lauenstein GG (2014) The Mussel Watch California pilot study on contaminants of emerging concern (CECs): synthesis and next steps. Mar Pollut Bull 81(2):355–363CrossRefGoogle Scholar
- Minh N, Minh T, Kajiwara N, Kunisue T, Subramanian A, Iwata H, Tana T, Baburajendran R, Karuppiah S, Viet P (2006) Contamination by persistent organic pollutants in dumping sites of Asian developing countries: implication of emerging pollution sources. Arch Environ Contam Toxicol 50(4):474–481CrossRefGoogle Scholar
- Miranda-García N, Suárez S, Sánchez B, Coronado JM, Malato S, Maldonado MI (2011) Photocatalytic degradation of emerging contaminants in municipal wastewater treatment plant effluents using immobilized TiO2 in a solar pilot plant. Appl Catal B 103(3–4):294–301CrossRefGoogle Scholar
- Nakada N, Shinohara H, Murata A, Kiri K, Managaki S, Sato N, Takada H (2007) Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant. Water Res 41(19):4373–4382CrossRefGoogle Scholar
- Nyenje P, Foppen J, Uhlenbrook S, Kulabako R, Muwanga A (2010) Eutrophication and nutrient release in urban areas of sub-Saharan Africa—a review. Sci Total Environ 408(3):447–455CrossRefGoogle Scholar
- OECD (2012) Water quality and agriculture: meeting the policy challenge. OECD studies on water -512012041E1, OECD Publishing, FranceGoogle Scholar
- Ohko Y, Ando I, Niwa C, Tatsuma T, Yamamura T, Nakashima T, Kubota Y, Fujishima A (2001) Degradation of bisphenol A in water by TiO2 photocatalyst. Environ Sci Technol 35(11):2365–2368CrossRefGoogle Scholar
- Otterpohl R (2002) Options for alternative types of sewerage and treatment systems directed to improvement of the overall performance. Water Sci Technol 45(3):149–158Google Scholar
- Ozaki H, Li H (2002) Rejection of organic compounds by ultra-low pressure reverse osmosis membrane. Water Res 36(1):123–130CrossRefGoogle Scholar
- Pal A, Gin KY, Lin AY, Reinhard M (2010) Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Sci Total Environ 408(24):6062–6069CrossRefGoogle Scholar
- Petrović M, Gonzalez S, Barceló D (2003) Analysis and removal of emerging contaminants in wastewater and drinking water. TrAC Trends Anal Chem 22(10):685–696CrossRefGoogle Scholar
- Phillips PJ, Schubertb C, Arguec D, Fisherb I, Furlongd ET, Foremand W, Grayd J, Chalmers A (2015) Concentrations of hormones, pharmaceuticals and other micropollutants in groundwater affected by septic systems in New England and New York. Sci Total Environ 512–513:43–54CrossRefGoogle Scholar
- Pomati F, Castiglioni S, Zuccato E, Fanelli R, Vigetti D, Rossetti C, Calamari D (2006) Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells. Environ Sci Technol 40(7):2442–2447CrossRefGoogle Scholar
- Porte C, Janer G, Lorusso LC, Ortiz-Zarragoitia M, Cajaraville MP, Fossi MC, Canesi L (2006) Endocrine disruptors in marine organisms: approaches and perspectives. Comp Biochem Physiol C 143(3):303–315Google Scholar
- Prieto-Rodriguez L, Miralles-Cuevas S, Oller I, Agüera A, Puma GL, Malato S (2012) Treatment of emerging contaminants in wastewater treatment plants (WWTP) effluents by solar photocatalysis using low TiO2 concentrations. J Hazard Mater 211–212:131–137CrossRefGoogle Scholar
- Purdom C, Hardiman P, Bye V, Eno N, Tyler C, Sumpter J (1994) Estrogenic effects of effluents from sewage treatment works. Chem Ecol 8(4):275–285CrossRefGoogle Scholar
- Rauch W, Brockmann D, Peters I, Larsen TA, Gujer W (2003) Combining urine separation with waste design: an analysis using a stochastic model for urine production. Water Res 37(3):681–689CrossRefGoogle Scholar
- Richardson SD (2003) Disinfection by-products and other emerging contaminants in drinking water. TrAC Trends Anal Chem 22(10):666–684CrossRefGoogle Scholar
- Richardson SD (2009) Water analysis: emerging contaminants and current issues. Anal Chem 81(12):4645–4677CrossRefGoogle Scholar
- Roefer P, Snyder S, Zegers RE, Rexing DJ, Fronk JL (2000) Endocrine-disrupting chemicals in a source water. J Am Water Works Assoc 92(8):52–58Google Scholar
- Schulz R (2003) Using a freshwater amphipod in situ bioassay as a sensitive tool to detect pesticide effects in the field. Environ Toxicol Chem 22(5):1172–1176CrossRefGoogle Scholar
- Sheiner EK, Sheiner E, Hammel RD, Potashnik G, Carel R (2003) Effect of occupational exposures on male fertility: literature review. Ind Health 41(2):55–62CrossRefGoogle Scholar
- Sheldon L, Umana M, Bursey J, Gutknecht W, Handy R, Hyldburg P, Michael L, Moseley A, Raymer J, Smith D (1986) Biological monitoring techniques for human exposure to industrial chemicals. Analysis of human fat, skin, nails, hair, blood, urine, and breath. U. S. Environmental Protection Agency, Office of Health and Environmental Assessment, Washington, DCGoogle Scholar
- Smital T, Luckenbach T, Sauerborn R, Hamdoun AM, Vega RL, Epel D (2004) Emerging contaminants—pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 552(1–2):101–117CrossRefGoogle Scholar
- Snyder SA, Kelly KL, Grange AH, Sovocool GW, Snyder EM, Giesy JP (2001) Pharmaceuticals and personal care products in the waters of Lake Mead, Nevada. In: AnonymousGoogle Scholar
- Snyder SA, Adham S, Redding AM, Cannon FS, DeCarolis J, Oppenheimer J, Wert EC, Yoon Y (2007) Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals. Desalination 202(1–3):156–181CrossRefGoogle Scholar
- Sodré FF, Locatelli MAF, Jardim WF (2010) Occurrence of emerging contaminants in Brazilian drinking waters: a sewage-to-tap issue. Water Air Soil Pollut 206(1–4):57–67CrossRefGoogle Scholar
- Sohoni P, Sumpter JP (1998) Several environmental oestrogens are also anti-androgens. J Endocrinol 158(3):327–339CrossRefGoogle Scholar
- Soliman MA, Pedersen JA, Park H, Castaneda-Jimenez A, Stenstrom MK, Suffet I (2007) Human pharmaceuticals, antioxidants, and plasticizers in wastewater treatment plant and water reclamation plant effluents. Water Environ Res 79(2):156–167CrossRefGoogle Scholar
- Sorensen JPR, Lapworth DJ, Nkhuwa DCW, Stuart ME, Gooddy DC, Bell RA, Chirwa M, Kabika J, Liemisa M, Chibesa M, Pedley S (2014) Emerging contaminants in urban groundwater sources in Africa. Water Res 72:51–63CrossRefGoogle Scholar
- Stavins RN (1997) Economic incentives for environmental regulation. Belfer Center for Science and International Affairs, John F. Kennedy School of Government, Harvard UniversityGoogle Scholar
- Teijon G, Candela L, Tamoh K, Molina-Díaz A, Fernández-Alba AR (2010) Occurrence of emerging contaminants, priority substances (2008/105/CE) and heavy metals in treated wastewater and groundwater at Depurbaix facility (Barcelona, Spain). Sci Total Environ 408(17):3584–3595CrossRefGoogle Scholar
- Ternes TA, Stüber J, Herrmann N, McDowell D, Ried A, Kampmann M, Teiser B (2003) Ozonation: a tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater? Water Res 37(8):1976–1982CrossRefGoogle Scholar
- Ternes TA, Joss A, Siegrist H (2004) Peer reviewed: scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ Sci Technol 38(20):392A–399ACrossRefGoogle Scholar
- Terzić S, Senta I, Ahel M, Gros M, Petrović M, Barcelo D, Müller J, Knepper T, Martí I, Ventura F, Jovančić P, Jabučar D (2008) Occurrence and fate of emerging wastewater contaminants in Western Balkan Region. Sci Total Environ 399(1–3):66–77CrossRefGoogle Scholar
- Tillitt DE, Ankley GT, Giesy JP, Ludwig JP, Kurita-Matsuba H, Weseloh DV, Ross PS, Bishop CA, Sileo L, Stromborg KL (1992) Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the great lakes. Environ Toxicol Chem 11(9):1281–1288CrossRefGoogle Scholar
- United States Environmental Protection Agency (USEPA) (1996) Draft framework for watershed based trading. EPA 800-R-96-00, Government Publications Office, Washington, DCGoogle Scholar
- United States Environmental Protection Agency (USEPA) (2000) Perfluorooctyl sulfonates; proposed significant new use rule. Fed Regist 65:62319–62333Google Scholar
- United States Environmental Protection Agency (USEPA) (2003) Draft risk assessment of the potential human health effects associated with exposure to perfluorooctanoic acid and its salts. http://www.epa.gov/opptintr/pfoa/pubs/pfoarisk.pdf
- United States Environmental Protection Agency (USEPA) (2010) Treating contaminants of emerging concern: A literature review database. USEPA, Office of Water, Washington, DC. EPA-820-R-10-002Google Scholar
- Van der Bruggen B, Schaep J, Wilms D, Vandecasteele C (1999) Influence of molecular size, polarity and charge on the retention of organic molecules by nanofiltration. J Membr Sci 156(1):29–41CrossRefGoogle Scholar
- Verlicchi P, Galletti A, Petrovic M, Barceló D (2010) Hospital effluents as a source of emerging pollutants: an overview of micropollutants and sustainable treatment options. J Hydrol 389(3–4):416–428CrossRefGoogle Scholar
- Vethaak AD, Lahr J, Schrap SM, Belfroid AC, Rijs GBJ, Gerritsen A, de Boer J, Bulder AS, Grinwis GCM, Kuiper RV, Legler J, Murk TAJ, Peijnenburg W, Verhaar HJM, de Voogt P (2005) An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere 59(4):511–524CrossRefGoogle Scholar
- Wang S (2009) Removal of emerging contaminants in biological treatment. Unpublished master’s thesis submitted to University of California, Los AngelesGoogle Scholar
- Westerhoff P, Yoon Y, Snyder S, Wert E (2005) Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. Environ Sci Technol 39(17):6649–6663CrossRefGoogle Scholar
- WHO (1993) Guidelines for drinking water quality. Vol. 1. Recommendations, 2nd edn. Word Health Organization, GenevaGoogle Scholar
- Wilkin RT, Fine DD, Burnett NG (2007) Perchlorate behavior in a municipal lake following fireworks displays. Environ Sci Technol 41(11):3966–3971CrossRefGoogle Scholar
- Winter HV, Sluis D (2000) Community Program of Research on Environmental Hormones and Endocrine Disruptors (COMPREHEND) Task 7: screening of long-term bream data in surface water, The Netherlands. Report no. C051/00, Netherlands Institute for Fisheries Research, IJmuiden, The NetherlandsGoogle Scholar
- Witte W (1998) Medical consequences of antibiotic use in agriculture. Science (New York, NY) 279(5353):996–997CrossRefGoogle Scholar
- Yangali-Quintanilla V, Maeng SK, Fujioka T, Kennedy M, Amy G (2010) Proposing nanofiltration as acceptable barrier for organic contaminants in water reuse. J Membr Sci 362(1–2):334–345CrossRefGoogle Scholar
- Zuccato E, Calamari D, Natangelo M, Fanelli R (2000) Presence of therapeutic drugs in the environment. Lancet 355(9217):1789–1790CrossRefGoogle Scholar
- Zwiener C, Frimmel FH (2000) Oxidative treatment of pharmaceuticals in water. Water Res 34(6):1881–1885CrossRefGoogle Scholar
- Zwiener C, Richardson SD, De Marini DM, Grummt T, Glauner T, Frimmel FH (2007) Drowning in disinfection byproducts? Assessing swimming pool water. Environ Sci Technol 41(2):363–372CrossRefGoogle Scholar