Adult attention deficit hyperactivity disorder: translating research into practice

  • A. N. Coogan
  • A. Dobrean
  • R. M. Donev
  • L. Mateescu
  • U. Müller
  • J. Thome
  • B. I. VoinescuEmail author
Review Article


Attention deficit hyperactivity disorder (ADHD) in adults is a prevalent, yet under-appreciated, under-researched and poorly understood condition. Given this, it is imperative that information and awareness regarding this condition are made more widespread, both amongst the general public and amongst healthcare professionals. Further, given our poor understanding of the aetiology of the condition, meaningful translational research that migrates into and better informs clinical practice must be a priority. In this brief review we highlight areas regarding the clinical diagnosis and management of ADHD in adults (guidelines, rating scales, pharmacotherapy, psychotherapy) as well as areas of promising translational research (genetics, neuroimaging, sleep and circadian rhythms, animal models of ADHD). We address some of the challenges presented for both clinicians and healthcare providers and research scientists working to improve the lives of those adults with ADHD.


ADHD Adult Guidelines Genetics Sleep 



This review is based on the results of an exploratory workshop that took place on 17–19 December 2011 at Babeş-Bolyai University, Cluj-Napoca, Romania, and was financially supported by CNCS—UEFISCDI, project number PNII—IDEI/WE-2011-056.


  1. Adler LA, Spencer TJ, Williams DW, Moore RJ, Michelson D (2008) Long-term, open-label safety and efficacy of atomoxetine in adults with ADHD: final report of a 4-year study. J Atten Disord 12(3):248–253. doi: 10.1177/1087054708316250 PubMedCrossRefGoogle Scholar
  2. Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, Deldar A, Schuh K, Durell T (2009) Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety 26(3):212–221. doi: 10.1002/da.20549 PubMedCrossRefGoogle Scholar
  3. American Psychiatric Association (2010) DSM-5: options being considered for ADHD. American Psychiatric Association. Accessed January 23 2012
  4. Asherson P, Adamou M, Bolea B, Müller U, Morua SD, Pitts M, Thome J, Young S (2010) Is ADHD a valid diagnosis in adults? Yes. Br Med J 340:736–737. doi: 10.1136/bmj.c549 CrossRefGoogle Scholar
  5. Baird AL, Coogan AN, Siddiqui A, Donev RM, Thome J (2011) Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatr. doi: 10.1038/mp.2011.149 Google Scholar
  6. Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, Danckaerts M, Döpfner M, Faraone S, Rothenberger A, Sergeant J, Steinhausen H-C, Sonuga-Barke E, Taylor E (2006) Long-acting medications for the hyperkinetic disorders. Eur Child Adoles Psychiatr 15(8):476–495. doi: 10.1007/s00787-006-0549-0 CrossRefGoogle Scholar
  7. Barkley RA (2006) Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment, 3rd edn. Guilford Press, New YorkGoogle Scholar
  8. Barkley RA, Murphy KR, Fischer M (2007) ADHD in adults: what the science says. Guilford Press, New YorkGoogle Scholar
  9. Boonstra AM, Kooij JJ, Oosterlaan J, Sergeant JA, Buitelaar JK, Van Someren EJ (2007) Hyperactive night and day? Actigraphy studies in adult ADHD: a baseline comparison and the effect of methylphenidate. Sleep 30(4):433–442PubMedGoogle Scholar
  10. Borbely AA (1982) A two process model of sleep regulation. Hum Neurobiol 1(3):195–204PubMedGoogle Scholar
  11. Boulanger LM (2009) Immune proteins in brain development and synaptic plasticity. Neuron 64(1):93–109. doi: 10.1016/j.neuron.2009.09.001 PubMedCrossRefGoogle Scholar
  12. Castells X, Ramos-Quiroga JA, Rigau D, Bosch R, Nogueira M, Vidal X, Casas M (2011) Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. CNS Drugs 25(2):157–169. doi: 10.2165/11539440-000000000-00000 PubMedCrossRefGoogle Scholar
  13. Chamberlain SR, Hampshire A, Müller U, Rubia K, del Campo N, Craig K, Regenthal R, Suckling J, Raoiser J, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009) Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological fMRT study. Biol Psychiatr 65:550–555. doi: 10.1016/j.biopsych.2008.10.014 CrossRefGoogle Scholar
  14. Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH (2011) Translational approaches to fronto-striatal dysfunction in attention-deficit hyperactivity disorder using CANTAB. Biol Psychiatr 69:1192–1203. doi: 10.1016/j.biopsych.2010.08.019 CrossRefGoogle Scholar
  15. Coghill D, Banaschewski T (2009) The genetics of attention-deficit/hyperactivity disorder. Expert Rev Neurother 9(10):1547–1565. doi: 10.1586/ern.09.78 PubMedCrossRefGoogle Scholar
  16. del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW (2011) The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder. Biol Psychiatr 69:e145–e157. doi: 10.1016/j.biopsych.2011.02.036 CrossRefGoogle Scholar
  17. Donev R, Thome J (2010) Inflammation: good or bad for ADHD? ADHD Atten Def Hyp Disord 2:257–266. doi: 10.1007/s12402-010-0038-7 CrossRefGoogle Scholar
  18. Emilsson B, Gudjonsson G, Sigurdsson JF, Baldursson G, Einarsson E, Olafsdottir H, Young S (2011) Cognitive behaviour therapy in medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. BMC Psychiatr 11:116. doi: 10.1186/1471-244X-11-116 CrossRefGoogle Scholar
  19. Faraone SV, Glatt SJ (2010) A comparison of the efficacy of medications for adults attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatr 71:754–763. doi: 10.4088/JCP.08m04902pur CrossRefGoogle Scholar
  20. Favorite B (1995) Coaching for adults with ADHD: the missing link between the desire for change and achievement of success. ADHD Report 3:11–12Google Scholar
  21. Fox AT, Hand DJ, Reilly MP (2008) Impulsive choice in a rodent model of attention-deficit/hyperactivity disorder. Behav Brain Res 187(1):146–152PubMedCrossRefGoogle Scholar
  22. Franke B, Faraone SV, Asherson P, Buitelaar J, Bau CH, Ramos-Quiroga JA, Mick E, Grevet EH, Johansson S, Haavik J, Lesch KP, Cormand B, Reif A (2011) The genetics of attention deficit/hyperactivity disorder in adults, a review. Mol Psychiatr. doi: 10.1038/mp.2011.138 Google Scholar
  23. Frodl T, Skokaukas N (2011) Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand [Epub ahead of print]Google Scholar
  24. Gainetdinov RR (2010) Strengths and limitations of genetic models of ADHD. Atten Defic Hyperact Disord 2(1):21–30. doi: 10.1007/s12402-010-0021-3 PubMedCrossRefGoogle Scholar
  25. Gong R, Ding C, Hu J, Lu Y, Liu F, Mann E, Xu F, Cohen MB, Luo M (2011) Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333(6049):1642–1646PubMedCrossRefGoogle Scholar
  26. Habel LA, Cooper WO, Sox CM, Chan KA, Fireman BH, Arbogast PG, Cheetham TC, Quinn VP, Dublin S, Boudreau DM, Andrade SE, Pawloski PA, Raebel MA, Smith DH, Achacoso N, Uratsu C, Go AS, Sidney S, Nguyen-Huynh MN, Ray WA, Selby JV (2011) ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. JAMA 306:2673–2683. doi: 10.1001/jama.2011.1830 PubMedCrossRefGoogle Scholar
  27. Hesslinger B, Tebartz van Elst L, Nyberg E, Dykiere P, Richter H, Berner M, Ebert D (2002) Psychotherapy of attention deficit hyper-activity disorder in adults—a pilot study using a structured skills training program. Eur Arch Psychiatr Clin Neurosci 252(4):177–184Google Scholar
  28. Hoebert M, van der Heijden KB, van Geijlswijk IM, Smits MG (2009) Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J Pineal Res 47(1):1–7. doi: 10.1111/j.1600-079X.2009.00681.x PubMedCrossRefGoogle Scholar
  29. Iversen L (2008) Speed, Ecstacy, Ritalin: the science of amphetamines. OUP, OxfordGoogle Scholar
  30. Kessler RC, Adler LA, Gruber MJ, Sarawate CA, Spencer T, Van Brunt DL (2007) Validity of the World Health Organization Adult ADHD self-report scale (ASRS) screener in a representative sample of health plan members. Int J Methods Psychiatr Res 16(2):52–65. doi: 10.1002/mpr.208 PubMedCrossRefGoogle Scholar
  31. Kissling C, Retz W, Wiemann S, Coogan AN, Clement RM, Hunnerkopf R, Conner AC, Freitag CM, Rosler M, Thome J (2008) A polymorphism at the 3′-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147(3):333–338. doi: 10.1002/ajmg.b.30602 PubMedGoogle Scholar
  32. Kooij SJ (2010) Adult ADHD. Diagnostic assessment and treatment. Pearson Assessment and Information BV, AmsterdamGoogle Scholar
  33. Kooij SJ, Bejerot S, Blackwell A, Caci H, Casas-Brugué M, Carpentier PJ, Edvinsson D, Fayyad J, Foeken K, Fitzgerald M, Gaillac V, Ginsberg Y, Henry C, Krause J, Lensing MB, Manor I, Niederhofer H, Nunes-Filipe C, Ohlmeier MD, Oswald P, Pallanti S, Pehlivanidis A, Ramos-Quiroga JA, Rastam M, Ryffel-Rawak D, Stes S, Asherson P (2010) European consensus statement on diagnosis and treatment of adult ADHD: the European network adult ADHD. BMC Psychiatr 10:67. doi: 10.1186/1471-244X-10-67 CrossRefGoogle Scholar
  34. Kubik JA (2010) Efficacy of ADHD coaching for adults with ADHD. J Atten Disord 13(5):442–453. doi: 10.1177/1087054708329960 PubMedCrossRefGoogle Scholar
  35. Langley K, Fowler TA, Grady DL, Moyzis RK, Holmans PA, van den Bree MB, Owen MJ, O’Donovan MC, Thapar A (2009) Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. Eur Child Adolesc Psychiatr 18(1):26–32. doi: 10.1007/s00787-008-0698-4 CrossRefGoogle Scholar
  36. Larriviere D, Williams MA, Rizzo M, Bonnie RJ (2009) Responding to requests from adult patients for neuroenhancements: guidance of the Ethics, law and humanities committee. Neurology 73(17):1406–1412. doi: 10.1212/WNL.0b013e3181beecfe PubMedCrossRefGoogle Scholar
  37. Leucht S, Heres S, Davis JM (2011) Überlegungen zur Wirksamkeit von Psychopharmaka. Nervenarzt 82:1425–1430. doi: 10.1007/s00115-011-3349-9 PubMedCrossRefGoogle Scholar
  38. Mahoney MJ, Arnkoff DB (1978) Cognitive and self-control therapies. In: Garfield SL, Bergin AE (eds) Handbook of psychotherapy and behavior change: an empirical analysis. Wiley, New York, pp 689–722Google Scholar
  39. Mehta MA, Krause J (2011) Emission tomography in ADHD. In: Buitelaar JK, Kan CC, Asherson P (eds) ADHD in adults. Characterization, diagnosis and treatment. Cambridge University Press, Cambridge, pp 75–90CrossRefGoogle Scholar
  40. Mill J, Sagvolden T, Asherson P (2005) Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct 1:24. doi: 1744-9081-1-24 PubMedCrossRefGoogle Scholar
  41. Murphy K (2005) Psychosocial treatments for ADHD in teens and adults: a practice-friendly review. J Clin Psychol 61:607–619. doi: 10.1002/jclp.20123 PubMedCrossRefGoogle Scholar
  42. Nakao T, Radua J, Rubia K, Mataix-Cols D (2011) Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. Am J Psychiatr 168(11):1154–1163. doi: 10.1176/appi.ajp.2011.11020281 PubMedGoogle Scholar
  43. O’Keeffe SM, Thome J, Coogan AN (2011) The noradrenaline reuptake inhibitor atomoxetine phase-shifts the circadian clock in mice. Neuroscience Google Scholar
  44. Oosterloo M, Lammers GJ, Overeem S, de Nord I, Kooij JJ (2006) Possible confusion between primary hypersomnia and adult attentions-deficit/hyperactivity disorder. Psychiatr Res 143:293–297. doi: 10.1016/j.psychres.2006.02.009 CrossRefGoogle Scholar
  45. Philipsen A, Graf E, Tebartz van Elst L, Jans T, Warnke A, Hesslinger B, Ebert D, Gerlach M, Matthies S, Colla M, Jacob C, Sobanski E, Alm B, Rösler M, Ihorst G, Gross-Lesch S, Gentschow L, Kis B, Huss M, Lieb K, Schlander M, Berger M (2010) Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial. ADHD Atten Defic Hyperact Disord 2:203–212. doi: 10.1007/s12402-010-0046-7 CrossRefGoogle Scholar
  46. Proal E, Reiss PT, Klein RG, Mannuzza S, Gotimer K, Ramos-Olazagasti MA, Lerch JP, He Y, Zijdenbos A, Kelly C, Milham MP, Castellanos FX (2011) Brain gray matter deficits at 33-year follow-up in adults with attention-deficit/hyperactivity disorder established in childhood. Arch Gen Psychiatr 68(11):1122–1134. doi: 68/11/1122 PubMedCrossRefGoogle Scholar
  47. Ramsay JR, Rostain AL (2007) Psychosocial treatments for attention-deficit/hyperactivity disorder in adults: Current evidence and future directions. Prof Psychol Res Pract 38:338–346. doi: 10.1037/0735-7028.38.4.338 CrossRefGoogle Scholar
  48. Retz W, Retz-Junginger P, Hengesch G, Schneider M, Thome J, Pajonk FG, Salahi-Disfan A, Rees O, Wender PH, Rosler M (2004) Psychometric and psychopathological characterization of young male prison inmates with and without attention deficit/hyperactivity disorder. Eur Arch Psychiatr Clin Neurosci 254(4):201–208. doi: 10.1007/s00406-004-0470-9 Google Scholar
  49. Retz W, Freitag CM, Retz-Junginger P, Wenzler D, Schneider M, Kissling C, Thome J, Rosler M (2008) A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: interaction with adverse childhood environment. Psychiatr Res 158(2):123–131. doi: 10.1016/j.psychres.2007.05.004 CrossRefGoogle Scholar
  50. Retz W, Retz-Junginger P, Thome J, Rosler M (2011) Pharmacological treatment of adult ADHD in Europe. World J Biol Psychiatr 12(Suppl 1):89–94. doi: 10.3109/15622975.2011.603229 Google Scholar
  51. Rodriguez PD, Simon-Dack SL (2011) Factor analysis of five adult ADHD self-report measures: are they all the same? J Atten Disord. doi: 1087054711423627 PubMedGoogle Scholar
  52. Rogers ES, Spalding SL, Eckard AA, Wallace LS (2009) Are patient-administered attention deficit hyperactivity disorder scales suitable for adults? J Atten Disord 13(2):168–174. doi: 1087054708323017 PubMedCrossRefGoogle Scholar
  53. Romanos M, Buske-Kirschbaum A, Fölster-Holst R, Gerlach M, Weidinger S, Schmitt J (2011) Itches and scratches—is there a link between eczema, ADHD, sleep disruption and food hypersensitivity? Allergy 66(11):1407–1409. doi: 10.1111/j.1398-9995.2011.02705.x PubMedCrossRefGoogle Scholar
  54. Rosler M, Retz W, Thome J, Schneider M, Stieglitz RD, Falkai P (2006) Psychopathological rating scales for diagnostic use in adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatr Clin Neurosci 256(Suppl 1):i3–i11. doi: 10.1007/s00406-006-1001-7 CrossRefGoogle Scholar
  55. Rosler M, Retz W, Stieglitz RD (2010) Psychopathological rating scales as efficacy parameters in adult ADHD treatment investigations—benchmarking instruments for international multicentre trials. Pharmacopsychiatry 43(3):92–98. doi: 10.1055/s-0029-1242819 PubMedCrossRefGoogle Scholar
  56. Rostain AL, Ramsay JR (2006) A combined treatment approach for adults with ADHD—Results of an open study of 43 patients. J Atten Disord 10:150–159. doi: 10.1177/1087054706288110 PubMedCrossRefGoogle Scholar
  57. Russell VA (2011) Overview of animal models of attention deficit hyperactivity disorder (ADHD). Curr Protoc Neurosci Chapter 9:Unit9 35. doi: 10.1002/0471142301.ns0935s54
  58. Safren SA (2006) Cognitive-behavioral approaches to ADHD treatment in adulthood. J Clin Psychiatr 67(Suppl 8):46–50Google Scholar
  59. Safren SA, Otto MW, Sprich S, Winett CL, Wilens TE, Biederman J (2005) Cognitive–behavioral therapy for ADHD in medication-treated adults with continued symptoms. Behav Res Ther 43:831–842. doi: 10.1016/j.brat.2004.07.001 PubMedCrossRefGoogle Scholar
  60. Safren SA, Sprich S, Mimiaga MJ, Surman C, Knouse L, Groves M, Otto MW (2010) Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA 304:875–880. doi: 10.1001/jama.2010.1192 PubMedCrossRefGoogle Scholar
  61. Sagvolden T (2000) Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD). Neurosci Biobehav Rev 24(1):31–39. doi: S0149-7634(99)00058-5 PubMedCrossRefGoogle Scholar
  62. Sagvolden T (2011) Impulsiveness, overactivity, and poorer sustained attention improve by chronic treatment with low doses of l-amphetamine in an animal model of attention-deficit/hyperactivity disorder (ADHD). Behav Brain Funct 7:6. doi: 1744-9081-7-6 PubMedCrossRefGoogle Scholar
  63. Sagvolden T, Johansen EB (2011) Rat models of ADHD. Curr Top Behav Neurosci. doi: 10.1007/7854_2011_126 Google Scholar
  64. Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M (2005) Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatr 57(11):1239–1247CrossRefGoogle Scholar
  65. Schneider M, Retz W, Coogan A, Thome J, Rosler M (2006) Anatomical and functional brain imaging in adult attention-deficit/hyperactivity disorder (ADHD)—a neurological view. Eur Arch Psychiatr Clin Neurosci 256(Suppl 1):i32–i41. doi: 10.1007/s00406-006-1005-3 CrossRefGoogle Scholar
  66. Schredl M, Alm B, Sobanski E (2007) Sleep quality in adult patients with attention deficit hyperactivity disorder (ADHD). Eur Arch Psychiatr Clin Neurosci 257(3):164–168. doi: 10.1007/s00406-006-0703-1 CrossRefGoogle Scholar
  67. Seixas M, Weiss M, Muller U (2011) Systematic review of national and international guidelines on attention-deficit hyperactivity disorder. J Psychopharmacol. doi: 0269881111412095 PubMedGoogle Scholar
  68. Shaw P, Sharp WS, Morrison M, Eckstrand K, Greenstein DK, Clasen LS, Evans AC, Rapoport JL (2009) Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder. Am J Psychiatr 166(1):58–63. doi: 10.1176/appi.ajp.2008.08050781 PubMedCrossRefGoogle Scholar
  69. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatr 59(Suppl 20):22–33Google Scholar
  70. Siesser WB, Zhao J, Miller LR, Cheng SY, McDonald MP (2006) Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive. Genes Brain Behav 5(3):282–297. doi: 10.1111/j.1601-183X.2005.00161.x PubMedCrossRefGoogle Scholar
  71. Simchon Y, Weizman A, Rehavi M (2010) The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD. Eur Neuropsychopharmacol 20(10):714–720PubMedCrossRefGoogle Scholar
  72. Smith AK, Mick E, Faraone SV (2009) Advances in genetic studies of attention-deficit/hyperactivity disorder. Curr Psychiatr Rep 11(2):143–148. doi: 10.1007/s11920-009-0022-0 CrossRefGoogle Scholar
  73. Solanto MV (2011) Cognitive-behavioral therapy for adult ADHD: targeting executive dysfunction. Guilford Press, New YorkGoogle Scholar
  74. Solanto MV, Marks DJ, Mitchell KJ, Wasserstein J, Kofman MD (2008) Development of a new psychosocial treatment for adult ADHD. J Atten Disord 11:728–736PubMedCrossRefGoogle Scholar
  75. Sontag TA, Tucha O, Walitza S, Lange KW (2010) Animal models of attention deficit/hyperactivity disorder (ADHD): a critical review. Atten Defic Hyperact Disord 2(1):1–20. doi: 10.1007/s12402-010-0019-x PubMedCrossRefGoogle Scholar
  76. Taylor E et al (2008) National institute for health and clinical excellence (NICE) attention deficit hyperactivity disorder—diagnosis and management of ADHD in children, young people and adults. NICE Clinical Guidelines 72Google Scholar
  77. Taylor E (2011) Antecedents of ADHD: a historical account of diagnostic concepts. ADHD Atten Def Hyp Disord 3(2):69–75. doi: 10.1007/s12402-010-0051-x CrossRefGoogle Scholar
  78. Taylor A, Deb S, Unwin G (2011) Scales for the identification of adults with attention deficit hyperactivity disorder (ADHD): a systematic review. Res Dev Disabil 32(3):924–938. doi: 10.1016/j.ridd.2010.12.036 PubMedCrossRefGoogle Scholar
  79. Thome J, Jacobs KA (2004) Attention deficit hyperactivity disorder (ADHD) in a 19th century children’s book. Eur Psychiatr 19(5):303–306. doi: 10.1016/j.eurpsy.2004.05.004.S0924933804001063 CrossRefGoogle Scholar
  80. Valenzuela M, Bartrés-Faz D, Beg F, Fornito A, Merlo-Pich E, Müller U, Öngür D, Toga AW, Yücel M (2011) Neuroimaging as endpoints in clinical trials: are we there yet? Perspectives from the first Provence workshop. Mol Psychiatr 16:1064–1066CrossRefGoogle Scholar
  81. van den Bergh FS, Bloemarts E, Chan JS, Groenink L, Olivier B, Oosting RS (2006) Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacol Biochem Behav 83(3):380–390PubMedCrossRefGoogle Scholar
  82. Van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB (2005) Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int 22(3):559–570. doi: 10.1081/CBI-200062410 PubMedCrossRefGoogle Scholar
  83. Van Veen MM, Kooij JJ, Boonstra AM, Gordijn MC, Van Someren EJ (2010) Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia. Biol Psychiatr 67(11):1091–1096CrossRefGoogle Scholar
  84. Van Voorhees EE, Hardy KK, Kollins SH (2011) Reliability and validity of self- and other-ratings of symptoms of ADHD in adults. J Atten Disord 15(3):224–234. doi: 1087054709356163 PubMedCrossRefGoogle Scholar
  85. Veerhuis R, Nielsen HM, Tenner AJ (2011) Complement in the brain. Mol Immunol 48(14):1592–1603PubMedCrossRefGoogle Scholar
  86. Virta M, Vedenpää A, Grönroos N, Chydenius E, Partinen M, Vataja R, Kaski M, Iivanainen M (2008) Adults with ADHD benefit from cognitive-behaviorally oriented group rehabilitation—a study of 29 participants. J Atten Disord 12:218–226. doi: 10.1177/1087054707311657 PubMedCrossRefGoogle Scholar
  87. Volkow ND, Wang GJ, Newcorn J, Telang F, Solanto MV, Fowler JS, Logan J, Ma Y, Schulz K, Pradhan K, Wong C, Swanson JM (2007) Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatr 64:932–940. doi: 10.1001/archpsyc.64.8.932 PubMedCrossRefGoogle Scholar
  88. Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, Fowler JS, Zhu W, Logan J, Ma Y, Pradhan K, Wong C, Swanson JM (2009) Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA 302(10):1084–1091. doi: 302/10/1084 PubMedCrossRefGoogle Scholar
  89. Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, Telang F, Fowler JS, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM (2011) Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Mol Psychiatr 16(11):1147–1154CrossRefGoogle Scholar
  90. Volkow ND, Wang GJ, Tomasi D, Kollins SH, Wigal TL, Newcorn JH, Telang FW, Fowler JS, Logan J, Wong CT, Swanson JM (2012) Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci 32:841–849. doi: 10.1523/JNEUROSCI.4461-11.2012 PubMedCrossRefGoogle Scholar
  91. Weiss M, Vincent A (2011) CADDRA Canadian and resource alliance Canadian ADHD practice guidelines (CAP-Guidelines), 3rd ednGoogle Scholar
  92. Weiss MD, Weiss JR (2004) A guide to the treatment of adults with ADHD. J Clin Psychiatr 65(Suppl. 3):23–37Google Scholar
  93. Won H, Mah W, Kim E, Kim JW, Hahm EK, Kim MH, Cho S, Kim J, Jang H, Cho SC, Kim BN, Shin MS, Seo J, Jeong J, Choi SY, Kim D, Kang C (2011) GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med 17(5):566–572PubMedCrossRefGoogle Scholar
  94. Wood DR, Reimherr FW, Wender PH, Johnson GE (1976) Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report. Arch Gen Psychiatr 33(12):1453–1460PubMedCrossRefGoogle Scholar
  95. Wulff K, Gatti S, Wettstein JG, Foster RG (2010) Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci 11(8):589–599PubMedCrossRefGoogle Scholar
  96. Xu X, Breen G, Chen CK, Huang YS, Wu YY, Asherson P (2010) Association study between a polymorphism at the 3′-untranslated region of CLOCK gene and attention deficit hyperactivity disorder. Behav Brain Funct 6:48PubMedCrossRefGoogle Scholar
  97. Yoon SY, Jain U, Shapiro C (2011) Sleep in attention-deficit/hyperactivity disorder in children and adults: Past, present, and future. Sleep Med Rev (in press)Google Scholar
  98. Young S, Gudjonsson GH (2005) Neuropsychological correlates of the YAQ-S and YAQ-I self- and informant-reported ADHD symptomatology, emotional and social problems and delinquent behaviour. Br J Clin Psychol 44(Pt 1):47–57. doi: 10.1348/014466504X197769 PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • A. N. Coogan
    • 1
  • A. Dobrean
    • 2
  • R. M. Donev
    • 3
    • 4
  • L. Mateescu
    • 5
  • U. Müller
    • 6
  • J. Thome
    • 3
    • 4
  • B. I. Voinescu
    • 2
    Email author
  1. 1.Department of PsychologyNational University of Ireland MaynoothMaynooth, LeinsterRepublic of Ireland
  2. 2.Department of Clinical Psychology and PsychotherapyBabeş-Bolyai UniversityCluj-NapocaRomania
  3. 3.Clinic and Policlinic of Psychiatry and PsychotherapyUniversity of RostockRostockGermany
  4. 4.College of MedicineSwansea UniversitySwanseaUK
  5. 5.Department of Child and Adolescent PsychiatryCarol Davila University of Medicine and PharmacyBucharestRomania
  6. 6.Department of PsychiatryUniversity of CambridgeCambridgeUK

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