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Evaluation of left ventricular volumes and ejection fraction by 99mTc-MIBI gated SPECT and 18F-FDG gated PET in patients with prior myocardial infarction

  • Yong Yao
  • Da-Wei Wang
  • Wei Fang
  • Yue-Qin Tian
  • Rui Shen
  • Xiao-Xin Sun
  • Feng Guo
  • Ke-Wei Chu
  • Chen Cui
  • Shi-Hua Zhao
  • Zuo-Xiang HeEmail author
Original Article
  • 8 Downloads

Abstract

Background

This study aimed to compare the accuracy of gated-SPECT (GSPECT) and gated-PET (GPET) in the assessment of left ventricular (LV) end-diastolic volumes (EDVs), end-systolic volumes (ESVs) and LV ejection fractions (LVEFs) among patients with prior myocardial infarction (MI).

Methods

One hundred and sixty-eight consecutive patients with MI who underwent GSPECT and GPET were included. Of them, 76 patients underwent CMR in addition to the two imaging modalities. The measurements of LV volumes and LVEF were performed using Quantitative Gated SPECT (QGS), Emory Cardiac Toolbox (ECTB), and 4D-MSPECT (4DM).

Results

The correlation between GPET, GSPECT, and CMR were excellent for LV EDV (r = 0.855 to 0.914), ESV (r = 0.852 to 0.949), and LVEF (r = 0.618 to 0.820), as calculated from QGS, ECTB, and 4DM. In addition, subgroup analysis revealed that EDV, ESV, and LVEF measured by GPET were accurate in patients with different extents of total perfusion defect (TPD), viable myocardium, and perfusion/metabolic mismatch. Furthermore, multivariate regression analysis identified that mismatch score was associated with the difference in EDV (P < 0.05) measurements between GPET and CMR.

Conclusions

In patients with MI, LV volumes and LVEF scores measured by both GSPECT and GPET imaging were comparable to those determined by CMR, but should not be interchangeable in individual patients.

Keywords

Myocardial infarction 99mTc-MIBI gated SPECT 18F-FDG gated PET CMR ejection fraction 

Abbreviations

EDV

End-diastolic volume

ESV

End-systolic volume

LVEF

Left ventricular ejection fraction

MI

Myocardial infarction

CMR

Cardiac magnetic resonance imaging

GPET

Gated positron emission tomography

GSPECT

Gated single photon emission computed tomography

TPD

Total perfusion defect

ECG

Electrocardiographic

QGS

Quantitative gated SPECT

Notes

Disclosure

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

12350_2019_1709_MOESM1_ESM.tif (109 kb)
Supplementary material 1 (TIFF 109 kb)
12350_2019_1709_MOESM2_ESM.pptx (49 kb)
Supplementary material 2 (PPTX 50 kb)

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Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  • Yong Yao
    • 1
  • Da-Wei Wang
    • 1
  • Wei Fang
    • 1
  • Yue-Qin Tian
    • 1
  • Rui Shen
    • 1
  • Xiao-Xin Sun
    • 1
  • Feng Guo
    • 1
  • Ke-Wei Chu
    • 1
  • Chen Cui
    • 2
  • Shi-Hua Zhao
    • 2
  • Zuo-Xiang He
    • 1
    • 3
    Email author
  1. 1.Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingPeople’s Republic of China
  3. 3.Department of Nuclear Medicine, Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijingPeople’s Republic of China

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