Barry L. Zaret, MD and H. William Strauss, MD

  • Frans J. Th. WackersEmail author
  • the History Corner
History Corner

Open image in new windowOpen image in new window In the early 1970s, management of coronary artery disease (CAD) was changing rapidly. Favaloro performed the first successful coronary artery bypass surgery (CABG) in 1967.1 Over the next few years, CABG became the standard of care in selected patients with angina pectoris. However, selection of suitable surgical candidates required invasive coronary angiography. In 1971 and 1973, Zaret and Strauss reported two seminal clinical studies that were timely and relevant for clinical cardiology.2,3 They demonstrated that using conventional nuclear imaging resting left ventricular function and regional wall motion could be quantified and that myocardial perfusion could be visualized, at rest and after exercise for detection of scar and myocardial ischemia.

The promise of noninvasive evaluation of patients with suspected CAD foreshadowed the beginning of the field of clinical nuclear cardiology. Within a few years, myocardial perfusion imaging...



The Members of the History Corner: George Beller, MD (Acting Chair); James Udelson, MD; Frans J. Th. Wackers, MD, PhD; Ignasi Carrio, MD.


The author declares that he has no conflict of interest.


  1. 1.
    Favaloro RG, Effler DB, Groves LK, Sheldon WC, Riahi M. Direct myocardial revascularization with saphenous vein autograft. Dis Chest 1969;56:279-83.CrossRefGoogle Scholar
  2. 2.
    Zaret BL, Strauss HW, Hurley PJ, Natarajan TK, Pitt B. A noninvasive scinitiphotographic method for detecting regional ventricular dysfunction in man. N Engl J Med 1971;284:1165-70.CrossRefGoogle Scholar
  3. 3.
    Strauss HW, Zaret BL, Martin ND, Wells HP, Flamm MD. Noninvasive evaluation of regional myocardial perfusion with potassium 43. Technique in patients with exercise-induced transient myocardial ischemia. Radiology 1973;108:85-90.CrossRefGoogle Scholar
  4. 4.
    Strauss HW, Zaret BL, Hurley PJ, Natarajan TK, Pitt B. A scintigraphic method for measuring left ventricular ejection fraction in man without cardiac catheterization. Am J Cardiol 1971;28:575-80.CrossRefGoogle Scholar
  5. 5.
    Zaret BL, Strauss HW, Martin ND, Wells HP, Flamm MD. Noninvasive regional myocardial perfusion with radioactive potassium. Study of patients at rest, with exercise and during angina pectoris. N Engl J Med 1973;288:809-12.CrossRefGoogle Scholar

Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  1. 1.Yale School of MedicineNew HavenUSA

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