Signal intensity of superb micro-vascular imaging associates with the activity of vascular inflammation in Takayasu arteritis
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Takayasu arteritis is an inflammatory disease of the arteries that involves the aorta and its main branches, especially subclavian and carotid arteries. Pathological data suggest that inflammatory activity evolves from the adventitia to the intima and finally encloses the whole layer.1Computed tomography (CT) and magnetic resonance imaging (MRI) can depict signs suggestive of vascular inflammation in the arteries such as arterial wall thickening, increased wall signal intensity, and perivascular edema. Although CT or MRI is a well-established modality for primary diagnosis of Takayasu arteritis, it has a limited clinical role in the long-term follow-up of those patients when reactivation of the disease is suspected. Also, 18F-labeled fluorodeoxyglucose (FDG)-positron emission tomography (PET) cannot be frequently used for monitoring disease activity because of the high risk of radiation exposure. Contrast-enhanced ultrasound of the carotid arteries can identify vascular...
This work was supported in part by research grants from the Kimura Memorial Foundation (to Atsuko Tahara, Shoko Maeda-Ogata, Munehisa Bekki, and Akihiro Honda); and the Grant-in-Aid for Scientific Research (Grant Number 17K09564 to Nobuhiro Tahara and Grant Number 17K16030 to Yoichi Sugiyama) from the Japan Society for the Promotion of Science (JSPS KAKENHI), Tokyo, Japan. Shinichiro Ito, Saki Hirakata, Shinjiro Kaieda, Sachiyo Igata, Ryoko Kuromatsu, Osamu Nakashima, and Yoshihiro Fukumoto have nothing to disclose.
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