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Prediction of sudden cardiac death in chronic heart failure patients with reduced ejection fraction by ADMIRE-HF risk score and early repolarization pattern

  • Iyo Ikeda-Yorifuji
  • Takahisa YamadaEmail author
  • Shunsuke Tamaki
  • Takashi Morita
  • Yoshio Furukawa
  • Yusuke Iwasaki
  • Masato Kawasaki
  • Atsushi Kikuchi
  • Tsutomu Kawai
  • Masahiro Seo
  • Eiji Fukuhara
  • Makoto Abe
  • Jun Nakamura
  • Masatake Fukunami
Original Article

Abstract

Background

AdreView myocardial imaging for risk evaluation in heart failure (ADMIRE-HF) risk score is a novel risk score to predict serious arrhythmic risk in chronic heart failure patients with reduced ejection fraction (HFrEF). Moreover, early repolarization pattern (ERP) has been shown to be associated with an increased risk of sudden cardiac death (SCD) in HFrEF patients. We sought to investigate the prognostic value of combining ADMIRE-HF risk score and ERP to predict SCD in HFrEF patients.

Methods

We studied 90 HFrEF outpatients with LVEF< 40% in our prospective cohort study. In cardiac MIBG imaging, the heart-to-mediastinum (H/M) ratio was measured on the delayed planar image. ADMIRE-HF risk score was derived from the sum of the point values of LVEF, H/M ratio, and systolic blood pressure. We also assessed ERP on the standard electrocardiogram.

Results

During a median follow-up of 7.5(4.5-12.0) years, 22 patients had SCD. At multivariate Cox analysis, ADMIRE-HF risk score and ERP were independently associated with SCD. Patients with both intermediate/high ADMIRE-HF score and ERP had a higher SCD risk than those with either and none of them.

Conclusion

The combination of ADMIRE-HF risk score and ERP would provide the incremental prognostic information for predicting SCD in HFrEF patients.

Keywords

Heart failure RNA: planar outcomes research cardiac innervation 

Abbreviations

ADMIRE-HF

AdreView myocardial imaging for risk evaluation in heart failure

HFrEF

Heart failure reduced ejection fraction

ERP

Early repolarization pattern

SCD

Sudden cardiac death

MIBG

Metaiodobenzylguanidine

LVEF

Left ventricular ejection fraction

H/M

Heart to mediastinum

ICD

Implantable cardioverter defibrillator

Notes

Disclosure

Iyo Ikeda-Yorifuji, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Masahiro Seo, Eiji Fukuhara, Makoto Abe, Jun Nakamura and Masatake Fukunami have no finantial or other relationships that could lead to a conflict of interest associated with this study.

Supplementary material

12350_2019_1639_MOESM1_ESM.pptx (1.3 mb)
Supplementary material 1 (PPTX 1351 kb)

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Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  • Iyo Ikeda-Yorifuji
    • 1
  • Takahisa Yamada
    • 1
    Email author
  • Shunsuke Tamaki
    • 1
  • Takashi Morita
    • 1
  • Yoshio Furukawa
    • 1
  • Yusuke Iwasaki
    • 1
  • Masato Kawasaki
    • 1
  • Atsushi Kikuchi
    • 1
  • Tsutomu Kawai
    • 1
  • Masahiro Seo
    • 1
  • Eiji Fukuhara
    • 1
  • Makoto Abe
    • 1
  • Jun Nakamura
    • 1
  • Masatake Fukunami
    • 1
  1. 1.Division of CardiologyOsaka General Medical CenterOsakaJapan

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