Journal of Nuclear Cardiology

, Volume 26, Issue 1, pp 59–67 | Cite as

F-18 FDG PET for assessment of disease activity of large vessel vasculitis: A systematic review and meta-analysis

  • Sang-Woo Lee
  • Seong-Jang KimEmail author
  • Youngduk Seo
  • Shin Young Jeong
  • Byeong-Cheol Ahn
  • Jaetae Lee
Original Article



The aim of this study is to investigate the performance of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for the assessment of disease activity in patients with large vessel vasculitis (LVV) through a meta-analysis.


The MEDLINE via PubMed and EMBASE were searched for the studies evaluating the performance of F-18 FDG PET or PET/CT in the assessment of disease activity in patients with LVV. Pooled sensitivity, specificity, diagnostic odds ratios (DORs), and summary receiver-operating characteristic (sROC) curve were estimated across the included studies. Possible publication bias was assessed by Deek’s funnel plot asymmetry tests.


A total of 439 PET images from 298 patients pooled from nine studies showed that the pooled sensitivity was 0.88 [95% confidence interval (CI) 0.79-0.93] without heterogeneity (χ2 = 14.42, P = .07) and the pooled specificity was 0.81 (95% CI 0.64-0.91) with heterogeneity (χ2 = 63.72, P = .00) for the detection of active LVV. The pooled DOR was 30 (95% CI 8-107). Hierarchical sROC curve indicates that the area under the curve was 0.91 (95% CI 0.89-0.94). There was no significant publication bias (P = .42), and meta-regression analysis revealed that none of the variables was the source of the study heterogeneity.


F-18 FDG PET has a good performance for the detection of active disease status in patients with LVV. Revised criteria for the assessment of disease activity incorporated with F-18 FDG PET or PET/CT should be introduced and validated. Further studies are warranted to determine if PET-based treatment of LVV can improve outcomes.


F-18 fluorodeoxyglucose PET large vessel vasculitis disease activity meta-analysis 



Diagnostic odds ratios


Erythrocyte sedimentation rates




Giant cell arteritis


Large vessel vasculitis


Positron emission tomography


Positron emission tomography/computed tomography


Maximum standardized uptake value


Takayasu’s arteritis



The authors of this manuscript declare no relationships with any companies products or services of which may be related to the subject matter of the article.

Informed Consent

Written informed consent was not required for this study because it is a meta-analysis based on the studies that have been published.

Ethical Approval

Institutional Review Board approval was not required because only the published studies were used in this meta-analysis. The manuscript has not been published before and is not under consideration for publication anywhere else.

Supplementary material

12350_2018_1406_MOESM1_ESM.pptx (1.1 mb)
Supplementary material 1 (pptx 1084 kb)


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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Sang-Woo Lee
    • 1
  • Seong-Jang Kim
    • 2
    • 3
    Email author
  • Youngduk Seo
    • 4
  • Shin Young Jeong
    • 1
  • Byeong-Cheol Ahn
    • 1
  • Jaetae Lee
    • 1
  1. 1.Department of Nuclear Medicine, School of MedicineKyungpook National UniversityTaeguSouth Korea
  2. 2.Department of Nuclear MedicinePusan National University Yangsan HospitalYangsanSouth Korea
  3. 3.BioMedical Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanSouth Korea
  4. 4.Department of Nuclear MedicineBusan Seongso HospitalPusanSouth Korea

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