Journal of Nuclear Cardiology

, Volume 25, Issue 2, pp 443–456 | Cite as

A case of longitudinal care of a patient with cardiac sarcoidosis

  • Rayan Saab
  • Pradeep Bhambhvani
  • Ami E. Iskandrian
  • Fadi G. Hage
Case Presentation Corner

Abstract

Cardiac sarcoidosis has long been an evasive diagnosis with a spectrum of clinical presentations that extend from asymptomatic to ventricular arrhythmias and sudden cardiac death. The diagnosis has traditionally relied on histology which suffers from the low sensitivity of endomyocardial biopsy due to the patchy nature of the disease in addition to its invasive nature. Due to significant advancements in imaging, it is now possible to accurately identify cardiac sarcoidosis using non-invasive imaging modalities even without histological confirmation. Emerging guidelines are highlighting the role of multimodality imaging in the diagnosis and management of this challenging entity. We present the case of a 36-year-old man known to have sarcoidosis in which a variety of imaging modalities not only assisted in the diagnosis of cardiac sarcoidosis, but also played a key role in the monitoring of disease activity and response to therapy.

Keywords

PET/CT imaging Magnetic resonance imaging Radiopharmaceuticals Inflammation Diagnostic and prognostic applications 

Abbreviations

CS

Cardiac sarcoidosis

TTE

Transthoracic echocardiogram

EMB

Endomyocardial biopsy

SPECT

Single-photon emission tomography

MPI

Myocardial perfusion imaging

FDG

Fluorodeoxyglucose

PET

Positron emission tomography

CMR

Cardiac magnetic resonance imaging

LGE

Late gadolinium enhancement

CCTA

Cardiac computer tomography angiography

Notes

Disclosures

Dr. Hage has received research grant support from Astellas Pharma. Drs. Bhambhvani, Iskandrian and Saab have no conflicts.

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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Rayan Saab
    • 1
  • Pradeep Bhambhvani
    • 2
  • Ami E. Iskandrian
    • 1
  • Fadi G. Hage
    • 1
    • 3
  1. 1.Division of Cardiovascular Disease, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Division of Molecular Imaging and Therapeutics, Department of RadiologyUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Section of CardiologyBirmingham Veterans Affairs Medical CenterBirminghamUSA

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