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Feasibility of simultaneous 99mTc-tetrofosmin and 123I-BMIPP dual-tracer imaging with cadmium-zinc-telluride detectors in patients undergoing primary coronary intervention for acute myocardial infarction

  • Yoshihiro Yamada
  • Shintaro NakanoEmail author
  • Youdou Gatate
  • Nanami Okano
  • Toshihiro Muramatsu
  • Shigeyuki Nishimura
  • Ichiei Kuji
  • Kenji Fukushima
  • Ichiro Matsunari
Original Article

Abstract

Background

Simultaneous dual-tracer imaging using isotopes with close photo-peaks may benefit from improved properties of cadmium-zinc-telluride (CZT)-based scanners.

Methods

Thirty patients having undergone primary percutaneous coronary intervention for acute myocardial infarction underwent single-(99mTc-tetrofosmin (TF) or 123I-BMIPP first) followed by simultaneous 99mTc-TF /123I-BMIPP dual-tracer imaging using a Discovery NM/CT 670 CZT. The values for the quantitative gated-SPECT (QGS) and the quantitative perfusion SPECT (QPS) were assessed.

Results

The intra-class correlation (ICC) coefficients between the single- and dual-tracer imaging were high in all the QGS and QPS data (Summed motion score: 0.95, summed thickening score: 0.94, ejection fraction: 0.98, SRS for 99mTc-TF: 0.97/ for 123I-BMIPP: 0.95). Wall motion, wall thickening and rest scores per coronary-territory-based regions were also comparable between the single- and dual imaging (ICC coefficient > 0.91). The interrater concordance in the visual analysis for the infarction and perfusion-metabolism mismatch was significant for the global and regional left ventricle (P < 0.001).

Conclusion

The quantitative/semi-quantitative values for global and regional left-ventricular function, perfusion, and fatty acid metabolism were closely comparable between the dual-tracer imaging and the single-tracer mode. These data suggests the feasibility of the novel CZT-based scanner for the simultaneous 99mTc-TF /123I-BMIPP dual-tracer acquisitions in clinical settings.

Keywords

Perfusion-metabolism mismatch CZT camera acute myocardial infarction dual imaging 

Notes

Acknowledgements

The authors acknowledged to technical staffs in the Saitama Medical University Hospital and Mr. Hideyasu Hosono (GE Healthcare) for their technical support in performing imaging examination and analysis.

Disclosure

None.

Supplementary material

12350_2018_1585_MOESM1_ESM.pptx (837 kb)
Supplementary material 1 (PPTX 836 kb)
12350_2018_1585_MOESM2_ESM.pdf (966 kb)
Supplementary material 2 (PDF 965 kb)
12350_2018_1585_MOESM3_ESM.pdf (153 kb)
Supplementary material 3 (PDF 154 kb)

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Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  • Yoshihiro Yamada
    • 1
  • Shintaro Nakano
    • 1
    Email author
  • Youdou Gatate
    • 1
  • Nanami Okano
    • 2
  • Toshihiro Muramatsu
    • 1
  • Shigeyuki Nishimura
    • 1
  • Ichiei Kuji
    • 3
  • Kenji Fukushima
    • 3
  • Ichiro Matsunari
    • 2
  1. 1.Department of Cardiology International Medical CenterSaitama Medical UniversitySaitamaJapan
  2. 2.Division of Nuclear Medicine, Department of RadiologySaitama Medical UniversitySaitamaJapan
  3. 3.Department of Nuclear Medicine International Medical CenterSaitama Medical UniversitySaitamaJapan

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