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Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components

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Journal of Nuclear Cardiology Aims and scope

Abstract

Coronary artery disease (CAD) is the most common and important cause of ischemic heart disease, with major implications on global morbidity and mortality. Non-invasive testing is crucial in the diagnostic and prognostic work-up of patients with or at risk of CAD, and also to guide decision making in terms of pharmacologic and revascularization therapy. The traditional paradigm is to view anatomic (i.e., coronary computed tomography) and functional imaging (e.g., myocardial perfusion scintigraphy) tests as opposing alternatives. Such approach is too reductionist and does not capitalize on the strengths of each type of test while risking to overlook the inherent limitations. The combination of anatomic and functional tests in a logic of hybrid imaging holds the promise of overcoming the limitations inherent to anatomic and functional testing, enabling more accurate diagnosis, prognosis, and guidance for revascularization in patients with CAD.

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Abbreviations

CAD:

Coronary artery disease

CMR:

Cardiac magnetic resonance

CT:

Computed tomography

CTA:

Computed tomography angiography

CTP:

Computed tomography perfusion

CZT:

Cadmium-zinc-telluride

CT-FFR:

Computed tomography fractional flow reserve

PET:

Positron emission tomography

SPECT:

Single-photon emission computed tomography

SYNTAX:

Synergy between PCI with Taxus and Cardiac Surgery

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Disclosure

Prof. Biondi-Zoccai has consulted for Abbott Vascular and Bayer. Dr. F. Nudi, Prof. Romagnoli, Prof. Schillaci, Dr. A. Nudi, and Prof. Versaci have nothing to disclose.

Author information

Authors and Affiliations

  1. Service of Hybrid Cardio Imaging, Madonna Della Fiducia Clinic, Rome, Italy

    Francesco Nudi MD & Alessandro Nudi MD

  2. Ostia Radiologica, Rome, Italy

    Francesco Nudi MD

  3. Replycare, Viale Africa 36, 00144, Rome, Italy

    Francesco Nudi MD & Alessandro Nudi MD

  4. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy

    Giuseppe Biondi-Zoccai MD, MStat

  5. IRCCS NEUROMED, Pozzilli, Italy

    Giuseppe Biondi-Zoccai MD, MStat & Orazio Schillaci MD

  6. Department of Radiology, Tor Vergata University, Rome, Italy

    Andrea Romagnoli MD

  7. Department of Nuclear Medicine, Tor Vergata University, Rome, Italy

    Orazio Schillaci MD

  8. Division of Cardiology, S. Maria Goretti Hospital, Latina, Italy

    Francesco Versaci MD

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  1. Francesco Nudi MD
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  2. Giuseppe Biondi-Zoccai MD, MStat
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Correspondence to Francesco Nudi MD.

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Funding: This work was supported by Replycare, Rome, Italy.

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Nudi, F., Biondi-Zoccai, G., Romagnoli, A. et al. Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components. J. Nucl. Cardiol. 26, 752–762 (2019). https://doi.org/10.1007/s12350-018-01562-2

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