Journal of Nuclear Cardiology

, Volume 26, Issue 1, pp 158–173 | Cite as

State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis

  • Vasvi Singh
  • Rodney Falk
  • Marcelo F. Di Carli
  • Marie Kijewski
  • Claudio Rapezzi
  • Sharmila DorbalaEmail author
Theme Article


Cardiac amyloidosis, once considered untreatable, is now gaining well-deserved attention due to advances in imaging and the recent approval of targeted breakthrough therapies. In this paper, we discuss the role of radionuclide imaging in the evaluation and management of patients with the most common form of amyloidosis—cardiac transthyretin amyloidosis (ATTR). We provide a comprehensive summary of the literature interspersed with our institutional experience as appropriate, to deliver our perspective.


Amyloid heart disease SPECT PET modalities molecular imaging 



Dr. Singh has no disclosures. Dr. Falk has research grants from Ionnis, Alnylam, Glaxo Smith Kline and Pfizer. He serves as a consultant for Proclara. Dr. Di Carli has research grant from Spectrum Dynamics and Gilead, and consulting fees from Sanofi and GE. Dr. Dorbala served as a consultant with Advanced Accelerator Applications, General Electric and Proclara. Dr. Rapezzi has research grants from Pfizer and consulting fees from Pfizer and Alnylam.

Supplementary material

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Supplementary material 1 (PPTX 1211 kb)


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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Vasvi Singh
    • 1
  • Rodney Falk
    • 2
  • Marcelo F. Di Carli
    • 1
  • Marie Kijewski
    • 1
  • Claudio Rapezzi
    • 3
  • Sharmila Dorbala
    • 1
    • 2
    • 4
    Email author
  1. 1.Division of Nuclear Medicine and Department of RadiologyBrigham and Women’s HospitalBostonUSA
  2. 2.Cardiac Amyloidosis ProgramBrigham and Women’s HospitalBostonUSA
  3. 3.Cardiology, Department of Experimental, Diagnostic and Specialty MedicineAlma Mater Studiorum, University of BolognaBolognaItaly
  4. 4.Cardiac Amyloidosis Program, Cardiovascular Division, Department of Medicine, Heart and Vascular Center, Division of Nuclear Medicine and Department of RadiologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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