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Left ventricular dyssynchrony and abnormalities in wall motion, assessed by gated-SPECT as ischemic auxiliary markers

  • Jorge Camilletti
  • Juan Erriest
  • Nilda Espinola-Zavaleta
  • Salvador Hernández-Sandoval
  • Mónica Redolatti
  • Luis Cartasegna
  • Víctor Arregui
  • Gustavo Vigo
  • Erick Alexanderson-RosasEmail author
Original Article
  • 46 Downloads

Abstract

Introduction

Left ventricular dyssynchrony (LVD) quantified by gated myocardial perfusion studies (MPS), through phase analysis (PA), has shown controversial results in myocardial stunning.

Objectives

Assessment of LVD and regional wall motion abnormalities (RWMA) in normal and ischemic patients.

Methods

A cohort of 172 patients were studied. Summed Stress Score (SSS), Summed Resting Score (SRS), and Summed Difference Score (SDS) were evaluated. Group 1-patients with normal MPS (N = 133) and Group 2-patients with myocardial ischemia in the MPS (N = 39). LVD was evaluated through PA and RWM by visual analysis.

Results

SSS 0 vs 9.8 ± 3.9 P = .0001; SDS 0 vs 9.8 ± 3.9 P = .0001; SRS 0 vs 0 P = NS, in G1 and G2. Significant differences were found in LVD between G1 and G2, bandwidth 36 ± 14 vs 63 ± 46 P = .0001; standard deviation 16 ± 10 vs 26 ± 15 P = .0001. In G1, 16% had LVD vs RWMA in 0%, P = .0001 and in G2, 59% with LVD vs 33% with RWMA, P = .03. Sensitivity for LVD 59% and for RWMA 33%, P = .03 and specificity for LVD 83% and for RWMA 100%, P = .0001.

Conclusion

Ischemic patients have LVD post-stress due to myocardial stunning. LVD measured by PA could be a useful tool to identify ischemia.

Keywords

Myocardial perfusion studies left ventricular dyssynchrony phase analysis standard deviation 

Abbreviations

LVD

Left ventricular dyssynchrony

PA

Phase analysis

MPS

Myocardial perfusion study

RWMA

Regional wall motion abnormalities

SSS

Summed stress score

SRS

Summed resting score

SDS

Summed difference score

CAD

Coronary artery disease

BW

Bandwidth

K

Kurtosis

Notes

Disclosure

There are no conflicts of interest between the authors.

Supplementary material

12350_2018_1544_MOESM1_ESM.pptx (54.9 mb)
Supplementary material 1 (PPTX 56264 kb)

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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Jorge Camilletti
    • 1
  • Juan Erriest
    • 1
  • Nilda Espinola-Zavaleta
    • 2
  • Salvador Hernández-Sandoval
    • 2
  • Mónica Redolatti
    • 1
  • Luis Cartasegna
    • 1
  • Víctor Arregui
    • 1
  • Gustavo Vigo
    • 1
  • Erick Alexanderson-Rosas
    • 2
    • 3
    Email author
  1. 1.Department of Nuclear CardiologyHospital Italiano de La PlataLa PlataArgentina
  2. 2.Departament of Nuclear CardiologyInstituto Nacional de Cardiología Ignacio ChávezMexico CityMexico
  3. 3.Department of Physiology, Medicine FacultyUNAMMexico CityMexico

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