Journal of Nuclear Cardiology

, Volume 26, Issue 1, pp 24–26 | Cite as

Cardiovascular disease in the literature: A selection of recent original research papers

  • Wael A. AlJaroudi
  • Fadi G. HageEmail author
Review of the Literature

Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release. J Am Coll Cardiol 2018;72:2040–50.

Background: Bilateral carpal tunnel syndrome is common in patients with cardiac amyloidosis, especially the transthyretin type (TTR), and usually precedes it by 5-10 years. Sperry et al. from Cleveland Clinic Foundation, Ohio performed a cross-sectional prospective study of 98 patients (median age 68 years, 51% men, 85% bilateral symptoms) undergoing carpal tunnel release surgery to determine the prevalence and type of amyloid deposits in the tenosynovium in addition to cardiac involvement.

Findings:On tenosynovial biopsy, 10 patients (10.2%) had amyloid deposits by Congo red staining (7 ATTR and 2 AL by mass spectrometry). Of these 10 patients, 2 had cardiac amyloidosis; one had AL amyloid with increased septal thickness by echocardiography, elevated NT-proBNP and cardiac troponin T and heart failure by exam. The other patient had TTR amyloid with septal hypertrophy...

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© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  1. 1.Division of Cardiovascular MedicineClemenceau Medical CenterBeirutLebanon
  2. 2.Division of Cardiovascular Disease, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Section of CardiologyBirmingham Veterans Affairs Medical CenterBirminghamUSA

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