Assessment of left ventricular contraction patterns using gated SPECT MPI to predict cardiac resynchronization therapy response
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The U-shaped left ventricular (LV) contraction pattern, identified by MRI or echocardiography, is associated with improved CRT response. Gated SPECT MPI can measure both myocardial viability and mechanical dyssynchrony in a single scan. The aim of this study is to examine the relationship of the LV contraction pattern and the response of CRT in patients with left bundle branch block (LBBB).
Fifty-eight patients who met CRT guidelines and who had pre-CRT MPI were enrolled. Myocardial segments with tracer uptake < 50% of maximum were considered as scar. The LV contraction pattern was considered as U-shaped or non-U-shaped (U-shaped has a block line in the direction of contraction propagation). CRT response was defined as an increase in left ventricular ejection fraction ≥ 5% after 6-month follow-up.
Twenty-eight patients (48%) had a U-shaped contraction pattern and thirty patients (52%) had a non-U-shaped contraction pattern. The U-shaped group showed a significantly higher response rate than the non-U-shaped group (90% vs. 57%; P = 0.005). By univariate and multivariate logistic regression analysis, the U-shaped pattern was an independent predictor of CRT response.
Non-invasive gated SPECT MPI can characterize LV mechanical contraction patterns. A U-shaped contraction pattern identified is associated with improved CRT response. This may prove useful for improved patient selection for CRT.
KeywordsSPECT MPI heart failure CRT contraction pattern left bundle branch block
Single-photon emission computed tomography
Myocardial perfusion imaging/images
Cardiac resynchronization therapy
Left bundle branch block
Left ventricular mechanical dyssynchrony
Phase standard deviation
Phase histogram bandwidth
This research was supported by a grant from Science and Technology Department of Jiangsu Province (Project Number: BE2016764, PI: Jiangang Zou) and a New Faculty startup grant from the University of Southern Mississippi (Project Number: DE01791, PI: Weihua Zhou).
The authors have declare that they have no conflict of interest.
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