Journal of Nuclear Cardiology

, Volume 25, Issue 3, pp 1029–1036 | Cite as

Validation of cadmium–zinc–telluride camera for measurement of left ventricular systolic performance

  • Elisabeth CoupezEmail author
  • Charles Merlin
  • Viateur Tuyisenge
  • Laurent Sarry
  • Bruno Pereira
  • Jean René Lusson
  • Louis Boyer
  • Lucie Cassagnes
Original Article



There are paucity of data comparing measurements of left ventricular systolic performance using cadmium–zinc–telluride (CZT) semiconductor cameras with other imaging modalities. This study compared the new system with echocardiography (echo) and cardiac magnetic resonance (CMR) imaging.


60 Patients presenting with ST-elevated myocardial infarction (MI) were included. Each patient underwent echo, myocardial perfusion imaging using Spectrum Dynamics D-SPECT(r) (CZT-SPECT), and CMR 6 weeks after MI. The primary endpoint was the agreement between CZT-SPECT and CMR for left ventricular ejection fraction (LVEF) measurement.


48 of the 60 patients underwent all 3 studies (echo, CMR, and CZT-SPECT) 40 days after admission. CZT-SPECT and CMR LVEF were well correlated (r = .79, P < .0001), as well as CZT-SPECT vs echo and CMR vs echo (r = .79 and .84, respectively, P < .0001). The segmental LV wall thickening and wall motion also showed good concordance between three techniques.


CZT-SPECT is reliable for LVEF measurement.

Key Words

Echocardiography magnetic resonance imaging myocardial perfusion imaging SPECT left ventricular function myocardial infarction 



Left ventricular ejection fraction


Cardiac magnetic resonance imaging


Cadmium-zinc-telluride Spectrum Dynamics D-SPECT®


End diastolic volume


End systolic volume


Wall motion


Wall thickening




Myocardial infarction


Myocardial perfusion imaging



The authors of this manuscript have no conflict of interest to declare.

Supplementary material

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Supplementary material 1 (DOC 32 kb)
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Supplementary material 2 (DOCX 16 kb)
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Supplementary material 3 (DOC 29 kb)
12350_2017_816_MOESM4_ESM.pptx (1.1 mb)
Supplementary material 4 (PPTX 1101 kb)


  1. 1.
    Zaret BL, Wackers FJ, Terrin ML, Forman SA, Williams DO, Knatterud GL, et al Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: Results of Thrombolysis in Myocardial Infarction (TIMI) phase II study. The TIMI Study Group. J Am Coll Cardiol 1995;26:73-9.CrossRefPubMedGoogle Scholar
  2. 2.
    Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, et al, CORE Study Investigators. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol 2002;39:30-6.CrossRefPubMedGoogle Scholar
  3. 3.
    Møller JE, Egstrup K, Køber L, Poulsen SH, Nyvad O, Torp-Pedersen C. Prognostic importance of systolic and diastolic function after acute myocardial infarction. Am Heart J 2003;145:147-53.CrossRefPubMedGoogle Scholar
  4. 4.
    Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, et al, American College of Cardiology Foundation, American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147-239.CrossRefPubMedGoogle Scholar
  5. 5.
    Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009;119:e391-479.CrossRefPubMedGoogle Scholar
  6. 6.
    Hoffmann R, von Bardeleben S, ten Cate F, Borges AC, Kasprzak J, Firschke C, et al Assessment of systolic left ventricular function: A multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J 2005;26:607-16.CrossRefPubMedGoogle Scholar
  7. 7.
    Darasz KH, Underwood SR, Bayliss J, Forbat SM, Keegan J, Poole-Wilson PA, et al Measurement of left ventricular volume after anterior myocardial infarction: Comparison of magnetic resonance imaging, echocardiography, and radionuclide ventriculography. Int J Cardiovasc Imaging 2002;18:135-42.CrossRefPubMedGoogle Scholar
  8. 8.
    Kirkpatrick JN, Vannan MA, Narula J, Lang RM. Echocardiography in heart failure: Applications, utility, and new horizons. J Am Coll Cardiol 2007;50:381-96.CrossRefPubMedGoogle Scholar
  9. 9.
    Nagueh SF, Bhatt R, Vivo RP, Krim SR, Sarvari SI, Russell K, et al Echocardiographic evaluation of hemodynamics in patients with decompensated systolic heart failure. Circ Cardiovasc Imaging 2011;4:220-7.CrossRefPubMedGoogle Scholar
  10. 10.
    Fedele F, Trambaiolo P, Magni G, De Castro S, Cacciotti L. New modalities of regional and global left ventricular function analysis: State of the art. Am J Cardiol 1998;81:49G-57G.CrossRefPubMedGoogle Scholar
  11. 11.
    Raman SV, Simonetti OP. The CMR examination in heart failure. Heart Fail Clin 2009;5:283-300, v.Google Scholar
  12. 12.
    Cwajg E, Cwajg J, He ZX, Hwang WS, Keng F, Nagueh SF, et al Gated myocardial perfusion tomography for the assessment of left ventricular function and volumes: Comparison with echocardiography. J Nucl Med Off Publ Soc Nucl Med 1999;40:1857-65.Google Scholar
  13. 13.
    Beller GA, Heede RC. SPECT imaging for detecting coronary artery disease and determining prognosis by noninvasive assessment of myocardial perfusion and myocardial viability. J Cardiovasc Transl Res 2011;4:416-24.CrossRefPubMedGoogle Scholar
  14. 14.
    Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med Off Publ Soc Nucl Med 2009;50:635-43.Google Scholar
  15. 15.
    Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol 2009;16:255-76.CrossRefGoogle Scholar
  16. 16.
    Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med Off Publ Soc Nucl Med 2009;50:554-62.Google Scholar
  17. 17.
    Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, et al A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol 2009;16:714-25.CrossRefGoogle Scholar
  18. 18.
    DePuey EG, Bommireddipalli S, Clark J, Thompson L, Srour Y. Wide beam reconstruction “quarter-time” gated myocardial perfusion SPECT functional imaging: A comparison to “full-time” ordered subset expectation maximum. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol 2009;16:736-52.CrossRefGoogle Scholar
  19. 19.
    Bailliez A, Blaire T, Mouquet F, Legghe R, Etienne B, Legallois D, et al Segmental and global left ventricular function assessment using gated SPECT with a semiconductor cadmium zinc telluride (CZT) camera: Phantom study and clinical validation vs cardiac magnetic resonance. J Nucl Cardiol 2014;21:712-22.CrossRefPubMedGoogle Scholar
  20. 20.
    Cochet H, Bullier E, Gerbaud E, Durieux M, Godbert Y, Lederlin M, et al Absolute quantification of left ventricular global and regional function at nuclear MPI using ultrafast CZT SPECT: Initial validation versus cardiac MR. J Nucl Med Off Publ Soc Nucl Med 2013;54:556-63.Google Scholar
  21. 21.
    Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: Quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol 2010;55:1965-74.CrossRefPubMedGoogle Scholar
  22. 22.
    Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: Comparison of 4 software programs. J Nucl Med Off Publ Soc Nucl Med 2001;42:1571-8.Google Scholar
  23. 23.
    Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2015;16:233-70.CrossRefPubMedGoogle Scholar
  24. 24.
    Bradley EL, Blackwood LG. Comparing paired data: A simultaneous test for means and variances. Am Stat 1989;43:234-5.Google Scholar
  25. 25.
    Steiger J, et al Tests for comparing elements of a correlation matrix. Psychol Bull 1983;87:245-51.CrossRefGoogle Scholar
  26. 26.
    Altman DG, et al Practical statistics for medical research. Boca Raton: CRC Press; 1991.Google Scholar

Copyright information

© American Society of Nuclear Cardiology 2017

Authors and Affiliations

  • Elisabeth Coupez
    • 1
    Email author
  • Charles Merlin
    • 2
  • Viateur Tuyisenge
    • 3
  • Laurent Sarry
    • 3
  • Bruno Pereira
    • 4
  • Jean René Lusson
    • 1
  • Louis Boyer
    • 5
  • Lucie Cassagnes
    • 5
  1. 1.Department of CardiologyCHU Gabriel MontpiedClermont-FerrandFrance
  2. 2.Nuclear Medicine DepartmentJean Perrin Cancer CenterClermont-FerrandFrance
  3. 3.ISIT, UMR CNRS 6284Université d’Auvergne Clermont1Clermont-FerrandFrance
  4. 4.DRCICHU Gabriel MontpiedClermont-FerrandFrance
  5. 5.Department of RadiologyCHU Gabriel MontpiedClermont-FerrandFrance

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