Journal of Nuclear Cardiology

, Volume 23, Issue 2, pp 287–297

Comparison of stress cardiovascular magnetic resonance imaging (CMR) with stress nuclear perfusion for the diagnosis of coronary artery disease

  • Ijaz G. Ahmad
  • Raushan K. Abdulla
  • Igor Klem
  • Roman Margulis
  • Alexander Ivanov
  • Ambreen Mohamed
  • Robert M. Judd
  • Salvatore Borges-Neto
  • Raymond J. Kim
  • John F. Heitner
Original Article



To assess the diagnostic performance of stress cardiac magnetic resonance (stress CMR) vs stress single-photon emission computed tomography (SPECT) in patients presenting to the emergency department (ED) with chest pain.


SPECT imaging is the most utilized outpatient procedure in the United States. The diagnostic accuracy of SPECT can be limited by soft tissue attenuation and low spatial resolution. Stress CMR has much higher spatial resolution and without the susceptibility to soft tissue attenuation.


Eighty-seven patients without a history of CAD presenting to the ED with chest pain were prospectively enrolled. Patients underwent both stress CMR and stress SPECT imaging within 12 hours of presentation. Both the stress imaging tests were interpreted immediately for clinical purposes and coronary angiography was performed if either was abnormal. Patients were considered to have significant CAD if identified by angiography (≥50%) or if a cardiac event (cardiac death, myocardial infarction or revascularization) occurred during follow-up (mean 2.6 ± 1.1 years).


Thirty-seven patients were referred for coronary angiography; 29 due to a positive stress test and eight patients for persistent chest pain despite two negative stress tests. There were 22 patients who had significant CAD (≥50%). The remaining patients were followed for 2.6 ± 1.1 years. At the conclusion of the follow-up period, there were four clinical events. The sensitivity, specificity, and diagnostic accuracy of CMR are 85%, 93%, and 89%, respectively. The sensitivity, specificity, and diagnostic accuracy of stress SPECT are 84%, 91%, and 88%, respectively.


Stress CMR has similar diagnostic accuracy as stress SPECT in diagnosis of CAD.


Magnetic resonance imaging myocardial perfusion imaging: SPECT coronary artery disease 



Coronary artery disease


Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease: a prospective trial




Emergency department


High-sensitivity C-reactive protein


Left ventricular


Myocardial infarction


Comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicenter, multivendor, randomized trial


Magnetic resonance imaging for myocardial perfusion assessment in coronary artery disease trial: perfusion-cardiac magnetic resonance vs single-photon emission computed tomography for the detection of coronary artery disease: a comparative multicenter, multivendor trial


Negative predictive value


Positron emission tomography


Positive predictive value


Single-photon emission computed tomography

Stress CMR

Stress cardiac magnetic resonance


Echo time


Repetition time


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Copyright information

© American Society of Nuclear Cardiology 2015

Authors and Affiliations

  • Ijaz G. Ahmad
    • 4
  • Raushan K. Abdulla
    • 4
  • Igor Klem
    • 1
    • 2
  • Roman Margulis
    • 4
  • Alexander Ivanov
    • 4
  • Ambreen Mohamed
    • 4
  • Robert M. Judd
    • 1
    • 2
  • Salvatore Borges-Neto
    • 3
  • Raymond J. Kim
    • 1
    • 2
  • John F. Heitner
    • 1
    • 2
    • 4
  1. 1.Duke Cardiovascular Magnetic Resonance CenterDuke University Medical CenterDurhamUSA
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA
  3. 3.Department of RadiologyDuke University Medical CenterDurhamUSA
  4. 4.Department of CardiologyNew York Methodist HospitalBrooklynUSA

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