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Journal of Nuclear Cardiology

, Volume 21, Issue 6, pp 1048–1056 | Cite as

Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease

  • Wen-Sheng Huang
  • Ching-Hui Huang
  • Cheng-Liang Lee
  • Ching-Pei ChenEmail author
  • Guang-Uei HungEmail author
  • Ji Chen
Original Article

Abstract

Background

Previous studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT myocardial perfusion imaging (MPI). The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of angiographic coronary artery disease (CAD).

Methods and Results

The MPI images of 144 patients were retrospectively analyzed. With ≥70% stenosis as the criteria of CAD, 57 had no CAD, 32 had 1-vessel disease, 36 had 2-vessel disease, and 19 had 3-vessel disease, respectively. LV global and territorial dyssynchrony parameters were measured by the phase analysis from stress/rest Tl-201 SPECT MPI and compared between stress and rest among the patient groups. The patients with multi-vessel CAD had significantly more global dyssynchrony than the patients without ≥70% stenosis at stress. The patients with multi-vessel CAD showed significantly more global and territorial dyssynchrony on stress images than on rest. More patients with 3-vessel CAD were correctly classified as multi-vessel disease, when combining both visual interpretation and dyssynchrony assessment.

Conclusion

The patients with multi-vessel CAD had significantly more global and territorial dyssynchrony at early post-stress than at rest. Such quantitative measures of myocardial stunning may assist in the diagnosis of multi-vessel CAD.

Keywords

Thallium-201 gated SPECT left-ventricular dyssynchrony myocardial ischemia 

Notes

Acknowledgments

This study was supported in part by a research grant from Changhua Christain Hospital (102-CCH-IRP-060) and an NIH Grant (1R01HL094438, PI: Ji Chen, PhD).

Disclosure

Dr Ji Chen receives royalties from the sale of Emory Cardiac Toolbox with SyncTool. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict-of-interest practice.

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Copyright information

© American Society of Nuclear Cardiology 2014

Authors and Affiliations

  • Wen-Sheng Huang
    • 1
    • 6
  • Ching-Hui Huang
    • 2
  • Cheng-Liang Lee
    • 2
  • Ching-Pei Chen
    • 3
    • 4
    Email author
  • Guang-Uei Hung
    • 5
    • 6
    • 7
    Email author
  • Ji Chen
    • 8
  1. 1.Department of Nuclear MedicineChanghua Christian HospitalChanghuaTaiwan
  2. 2.Department of CardiologyChanghua Christian HospitalChanghuaTaiwan
  3. 3.Division of Cardiology, Department of Internal MedicineChanghua Christian HospitalChanghuaTaiwan
  4. 4.Department of Beauty ScienceGraduate Institute of Beauty Science TechnologyChanghuaTaiwan
  5. 5.Department of Nuclear MedicineChang-Bing Show Chwan Memorial HospitalChanghuaTaiwan
  6. 6.Department of Medical Imaging and Radiological ScienceCentral Taiwan University of Science and TechnologyTaichungTaiwan
  7. 7.Department of Biomedical Imaging and Radiological ScienceChina Medical UniversityTaichungTaiwan
  8. 8.Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaUSA

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