Journal of Nuclear Cardiology

, Volume 22, Issue 2, pp 308–318 | Cite as

Data-driven respiratory motion tracking and compensation in CZT cameras: A comprehensive analysis of phantom and human images

  • Chi-Lun Ko
  • Yen-Wen WuEmail author
  • Mei-Fang Cheng
  • Ruoh-Fang Yen
  • Wen-Chau Wu
  • Kai-Yuan Tzen
Original Article



This study described a method for tracking and compensating respiratory motion in cadmium-zinc-telluride (CZT) cameras. We evaluated motion effects on myocardial perfusion imaging and assessed the usefulness of motion compensation in phantom and clinical studies.


SPECT studies were obtained from an oscillating heart phantom and 552 patients using CZT cameras with list-mode acquisition. Images were reformatted in 500-ms frames, and the activity centroid was calculated as respiratory signal. The myocardial perfusion, left ventricular (LV) wall thickness, and LV volume were assessed before and after the motion compensation technique.


In phantom studies, we documented only minimal bias between simulated and measured shifts. Significantly reduced tracer activity, increased wall thickness and decreased volume in scans with 15 mm or more axial shifts were noted. In clinical studies, there was a higher prevalence of significant motion after treadmill exercise. The motion compensation technique could successfully compensate those motion artifacts.


The described method allows for tracking and compensating respiratory motion in CZT cameras. Significant respiratory motion is still not uncommon using CZT cameras, especially in patients who underwent treadmill tests. Motion blurring can be compensated using image processing techniques and image quality could be significantly improved.


List mode myocardial perfusion imaging (MPI) cadmium-zinc-telluride (CZT) respiratory motion motion compensation 



This study was partially supported by Grants NSC 100-2314-B-002-158 and NSC 101-2314-B-002-151-MY3 from National Science Council of Taiwan.




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Copyright information

© American Society of Nuclear Cardiology 2014

Authors and Affiliations

  • Chi-Lun Ko
    • 1
    • 2
  • Yen-Wen Wu
    • 2
    • 3
    • 4
    • 5
    Email author
  • Mei-Fang Cheng
    • 2
  • Ruoh-Fang Yen
    • 2
  • Wen-Chau Wu
    • 6
  • Kai-Yuan Tzen
    • 2
  1. 1.Department of Nuclear MedicineNational Taiwan University Hospital Yun-Lin BranchDouliou CityTaiwan
  2. 2.Department of Nuclear MedicineNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  3. 3.Division of Cardiology, Department of Internal MedicineNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  4. 4.Department of Nuclear Medicine and Cardiology Division of Cardiovascular Medical CenterFar Eastern Memorial HospitalNew Taipei CityTaiwan
  5. 5.National Yang-Ming University School of MedicineTaipeiTaiwan
  6. 6.Graduate Institute of OncologyNational Taiwan UniversityTaipeiTaiwan

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