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Journal of Nuclear Cardiology

, Volume 21, Issue 5, pp 993–1000 | Cite as

F-18 FDG PET/CT in the evaluation of Takayasu arteritis: An experience from the tropics

  • Sampath Santhosh
  • Bhagwant Rai Mittal
  • Shankaramurthy Gayana
  • Anish Bhattacharya
  • Aman Sharma
  • Sanjay Jain
Original Article

Abstract

Objective

To evaluate the performance parameters of FDG PET/CT in patients with Takayasu arteritis at diagnosis and during immunosuppression.

Methods

Retrospective analysis of 60 FDG PET/CT studies in 51 patients was performed (17 scans at diagnosis out of which 4 had follow-up scans also and 43 scans on immunosuppression). The degree of FDG uptake in the vessels was assessed visually using a 4-point scale and maximum standardized uptake value (SUVmax), SUVratio, extent of vasculitis and association with ESR were calculated.

Results

PET/CT was positive for active vasculitis in all 17 patients at diagnosis. The mean SUVmax and mean SUV ratio of the active areas were 5.1 ± 3.0 and 3.2 ± 1.9, respectively. On immunosuppression, PET scan was positive for active vasculitis in 14/43 (32.5%) scans. The mean SUVmax and mean SUVratio of the active areas were 1.7 ± 2.1 and 0.95 ± 1.2, respectively. There was significant difference between the mean SUVmax and mean SUVratio at diagnosis and on immunosuppression, respectively (P < .01). The median number of vascular segments in each uptake grade group was also statistically different (P < .01) between scans at diagnosis and on immunosuppression. The median ESR level in PET positive scans was 29 mm/hour (2-53), whereas in PET negative scans was 35.5 mm/hour (6-50) and the difference was not statistically significant.

Conclusion

FDG PET/CT showed good sensitivity to detect active vasculitis at diagnosis and during immunosuppression. The change in SUVmax between the successive FDG PET/CT scans may give an objective assessment of response to immunosuppression.

Keywords

Takayasu arteritis vasculitis immunosupression FDG PET/CT 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

Disclosure

The authors have no direct or indirect commercial/financial incentive associated with publishing the article. No funding has been received for this work from any of the organizations.

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Copyright information

© American Society of Nuclear Cardiology 2014

Authors and Affiliations

  • Sampath Santhosh
    • 1
  • Bhagwant Rai Mittal
    • 1
  • Shankaramurthy Gayana
    • 1
  • Anish Bhattacharya
    • 1
  • Aman Sharma
    • 2
  • Sanjay Jain
    • 2
  1. 1.Department of Nuclear Medicine & PETPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of Internal MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia

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