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Journal of Nuclear Cardiology

, Volume 21, Issue 2, pp 351–367 | Cite as

The effect of bone marrow mononuclear stem cell therapy on left ventricular function and myocardial perfusion

  • Kamel SadatEmail author
  • Sameer Ather
  • Wael Aljaroudi
  • Jaekyeong Heo
  • Ami E. Iskandrian
  • Fadi G. Hage
Original Article

Abstract

Background

Bone morrow stem cell (BMC) transfer is an emerging therapy with potential to salvage cardiomyocytes during acute myocardial infarction and promote regeneration and endogenous repair of damaged myocardium in patients with left ventricular (LV) dysfunction. We performed a meta-analysis to examine the association between administration of BMC and LV functional recovery as assessed by imaging.

Methods and Results

Our meta-analysis included data from 32 trials comprising information on 1,300 patients in the treatment arm and 1,006 patients in the control arm. Overall, BMC therapy was associated with a significant increase in LV ejection fraction by 4.6% ± 0.7% (P < .001) (control-adjusted increase of 2.8% ± 0.9%, P = .001), and a significant decrease in perfusion defect size by 9.5% ± 1.4% (P < .001) (control-adjusted decrease of 3.8% ± 1.2%, P = .002). The effect of BMC therapy was similar whether the cells were administered via intra-coronary or intra-myocardial routes and was not influenced by baseline ejection fraction or perfusion defect size.

Conclusions

BMC transfer appears to have a positive impact on LV recovery in patients with acute coronary syndrome and those with stable coronary disease with or without heart failure. Most studies were small and a minority used a core laboratory for image analysis.

Keywords

Bone marrow stem cell myocardial perfusion imaging single-photon emission computed tomography cardiac magnetic resonance imaging echocardiography myocardial infarction stable coronary artery disease heart failure 

Notes

Disclosures

None.

Supplementary material

12350_2013_9846_MOESM1_ESM.doc (462 kb)
Supplementary material 1 (DOC 461 kb)

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Copyright information

© American Society of Nuclear Cardiology 2013

Authors and Affiliations

  • Kamel Sadat
    • 1
    Email author
  • Sameer Ather
    • 1
  • Wael Aljaroudi
    • 2
  • Jaekyeong Heo
    • 1
  • Ami E. Iskandrian
    • 1
  • Fadi G. Hage
    • 1
    • 3
  1. 1.Division of Cardiovascular DiseaseUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Division of Cardiovascular DiseaseAmerican University of Beirut Medical CenterBeirutLebanon
  3. 3.Section of CardiologyBirmingham Veterans Affairs Medical CenterBirminghamUSA

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