Journal of Nuclear Cardiology

, 16:122

Takotsubo cardiomyopathy: State-of-the-art review

Review Article

DOI: 10.1007/s12350-008-9015-3

Cite this article as:
Dorfman, T.A. & Iskandrian, A.E. J. Nucl. Cardiol. (2009) 16: 122. doi:10.1007/s12350-008-9015-3


Takotsubo cardiomyopathy (TC) is characterized by transient, often severe, left ventricular dysfunction and electrocardiographic changes that might mimic acute myocardial infarction in the absence of significant obstructive coronary artery disease. It is often encountered in elderly women after physical or emotional stress. Excessive catecholamine stimulation, metabolic abnormalities, and microcirculatory dysfunction are thought to be responsible for the manifestations of this disorder. This comprehensive review summarizes relevant published data, atypical presentations, pathophysiology, and management strategy. It also includes a review of 789 patients with TC including nine illustrative cases encountered at our institution.


Takotsubo cardiomyopathy stress-induced cardiomyopathy left ventricular apical ballooning myocardial stunning 

Copyright information

© American Society of Nuclear Cardiology 2008

Authors and Affiliations

  1. 1.Division of Cardiovascular Diseases, Department of MedicineThe University of Alabama at BirminghamBirminghamUSA

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