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Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo-controlled intervention study

  • Original Article
  • Published:
Mediterranean Journal of Nutrition and Metabolism

Abstract

A prospective, randomized, double-blind, placebo-controlled study was designed with 40 healthy individuals with joint discomfort. The effect of oral supplementation with a natural product containing hyaluronic acid included in a yoghurt matrix was evaluated in terms of functional and quality-of-life parameters. An isokinetic dynamometer was used to measure maximum muscle strength, total work and mean power. Participants were divided into 2 groups (n = 20) and ate yoghurt that was either supplemented or not supplemented with the hyaluronic acid product daily for a period of 90 days. The increase in the maximum peak torque of the knee extensors compared to baseline values was 7.6 ± 7.6 Nm for the supplemented yoghurt group and 2.5 ± 4.7 Nm for the control group at 180°/s (P = 0.0582), and 6.5 ± 5.8 Nm for the supplemented yoghurt group and −1.0 ± 7.1 Nm for the control group at 240°/s (P < 0.05). The same pattern of response was observed in total work and in mean power (P < 0.05). Differences were less pronounced in the knee flexors. No differences were detected in the Lequesne score and SF-36 survey except for the social functioning subscale at 1 month follow-up. This prospective placebo-controlled nutritional study confirmed that 3 months of oral administration of a natural product containing HA (Mobilee™) in healthy individuals with joint discomfort of the knee provides improvements in muscle strength.

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Abbreviations

HA:

Hyaluronic acid

OA:

Osteoarthritis

CT:

Control

SP:

Supplemented

References

  1. Kramer JS, Yelin EH, Epstein WV (1983) Social and economic impacts of four musculoskeletal conditions. A study using national community-based data. Arthritis Rheum 26:901–907

    Article  CAS  Google Scholar 

  2. Owens S, Wagner P, Vangsness CT Jr (2004) Recent advances in glucosamine and chondroitin supplementation. J Knee Surg 17:185–193

    Google Scholar 

  3. Hadler NM (1992) Knee pain is the malady—not osteoarthritis. Ann Intern Med 116:598–599

    Article  CAS  Google Scholar 

  4. Das SK, Farooqi A (2008) Osteoarthritis. Best Pract Res Clin Rheumatol 22:657–675

    Article  CAS  Google Scholar 

  5. McCarty MF, Russell AL, Seed MP (2000) Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis. Med Hypotheses 54:798–802

    Article  CAS  Google Scholar 

  6. Ghosh P (1994) The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin Exp Rheumatol 12:75–82

    CAS  Google Scholar 

  7. Fraser JR, Clarris BJ, Baxter E (1979) Patterns of induced variation in the morphology, hyaluronic acid secretion, and lysosomal enzyme activity of cultured human synovial cells. Ann Rheum Dis 38:287–294

    Article  CAS  Google Scholar 

  8. Balazs EA, Watson D, Duff IF, Roseman S (1967) Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis Rheum 10:357–376

    Article  CAS  Google Scholar 

  9. Smith MM, Ghosh P (1987) The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int 7:113–122

    Article  Google Scholar 

  10. Dougados M, Nguyen M, Listrat V, Amor B (1993) High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial. Osteoarthr Cartil 1:97–103

    Article  CAS  Google Scholar 

  11. Altman RD, Moskowitz R (1998) Intraarticular sodium hyaluronate (hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. J Rheumatol 25:2203–2211

    CAS  Google Scholar 

  12. Schmitt LC, Fitzgerald GK, Reisman AS, Rudolph KS (2008) Instability, laxity, and physical function in patients with medial knee osteoarthritis. Phys Ther 88:1506–1516

    Article  Google Scholar 

  13. Torrent A, Ruhí R, Theodosakis J, Blanco FJ (2009) Comparative efficacy of IB0004, extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous ha by human synoviocytes. Osteoarthr Cartil 17:S278–S279

    Article  Google Scholar 

  14. Balogh L, Polyak A, Mathe D, Kiraly R, Thuroczy J, Terez M, Janoki G, Ting Y, Bucci LR, Schauss AG (2008) Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem 56:10582–10593

    Article  CAS  Google Scholar 

  15. Martinez-Puig D, Carmona JU, Arguelles D, Deulofeu R, Ubia A, Prades M (2008) Oral hyaluronic acid administration improves osteochondrosis clinical symptoms and slightly increases intra-articular concentration of hyaluronic acid in a horse model: a pilot survey. Osteoarthr Cartil 15:C62–C63

    Article  Google Scholar 

  16. Lequesne MG, Mery C, Samson M, Gerard P (1987) Indexes of severity for osteoarthritis of the hip and knee. Validation. Value in comparison with other assessment tests. Scand J Rheumatol 65:85–89

    Article  CAS  Google Scholar 

  17. McHorney CA, Ware JE, Raczek AE (1993) The MOS 36-item short-form health survey (SF-36): II Psychometric and clinical test of validity in measuring physical and mental health constructs. Med Care 31:247–263

    Article  CAS  Google Scholar 

  18. Kannus P (1992) Normality, variability and predictability of work, power and torque acceleration energy with respect to peak torque in isokinetic testing. Int J Sports Med 13:249–256

    Article  CAS  Google Scholar 

  19. Tang SF, Chen CP, Chen MJ, Pei YC, Lau YC, Leong CP (2004) Changes in sagittal ground reaction forces after intra-articular hyaluronate injections for knee osteoarthritis. Arch Phys Med Rehabil 85:951–955

    Article  Google Scholar 

  20. Miltner O, Schneider U, Siebert CH, Niedhart C, Niethard FU (2002) Efficacy of intraarticular hyaluronic acid in patients with osteoarthritis—a prospective clinical trial. Osteoarthr Cartil 10:680–686

    Article  CAS  Google Scholar 

  21. Gur H, Cakin N (2003) Muscle mass, isokinetic torque, and functional capacity in women with osteoarthritis of the knee. Arch Phys Med Rehabil 84:1534–1541

    Article  Google Scholar 

  22. Balazs EA, Denlinger JL (1985) Sodium hyaluronate and joint function. J Equine Vet Sci 5:217–228

    Article  Google Scholar 

  23. Pelletier J-P, Roughley PJ, DiBattista JA, McCollum R, Martel-Pelletier J (1991) Are cytokines involved in osteoarthritis pathophysiology? Semin Arthritis Rheum 20:12–25

    Article  CAS  Google Scholar 

  24. Coleman PJ, Scott D, Ray J, Mason RM, Levick JR (1997) Hyaluronan secretion into the synovial cavity of rabbit knees and comparison with albumin turnover. J Physiol 15:645–656

    Article  Google Scholar 

  25. Peyron JG (1993) Intraarticular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review. J Rheumatol Suppl 39:10–15

    CAS  Google Scholar 

  26. Nishikawa H, Mori I, Umemoto J (1985) Influences of sulfated glycosaminoglycans on biosynthesis of hyaluronic acid in rabbit knee synovial membrane. Arch Biochem Biophys 240:146–153

    Article  CAS  Google Scholar 

  27. Nishikawa H, Mori I, Umemoto J (1988) Glycosaminoglycan polysulfate-induced stimulation of hyaluronic acid synthesis in rabbit knee synovial membrane: involvement of binding protein and calcium ion. Arch Biochem Biophys 266:201–209

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Bioiberica S.A., Palafolls, Barcelona, Spain

    Daniel Martinez-Puig & Carlos Chetrit

  2. Instituto Poal de Reumatología, Barcelona, Spain

    Ingrid Möller

  3. Centro de Rehabilitación y Medicina del Deporte Eurosport, Barcelona, Spain

    César Fernández

Authors
  1. Daniel Martinez-Puig
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  2. Ingrid Möller
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  3. César Fernández
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  4. Carlos Chetrit
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Correspondence to Daniel Martinez-Puig.

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Martinez-Puig, D., Möller, I., Fernández, C. et al. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo-controlled intervention study. Mediterr J Nutr Metab 6, 63–68 (2013). https://doi.org/10.1007/s12349-012-0108-9

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  • DOI: https://doi.org/10.1007/s12349-012-0108-9

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