Could JC virus be linked to chronic idiopathic intestinal pseudo-obstruction?
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Abstract
JC virus is a member of the Polyomavirus family, infects humans worldwide, and 90% of the population carry antibodies to the virus by adult life. The initial infection is asymptomatic, but it may become persistent. JC virus DNA is frequently present in the upper and lower gastrointestinal tracts of healthy adults. Chronic idiopathic intestinal pseudo-obstruction, one of the most severe gastrointestinal motility disorders, is a condition characterized by a clinical picture mimicking small bowel occlusion with related symptoms and signs in the absence of demonstrable mechanical obstruction. Because of the known neuropathic capability of this virus, and its frequent presence in the gut, it has been proposed that JCV might be detectable in tissues of patients with chronic idiopathic intestinal pseudo-obstruction, and possibly be involved in the pathogenesis of this disease, because the virus may actively infect the enteroglial cells of the myenteric plexuses of the patients with chronic idiopathic intestinal pseudo-obstruction. We report two cases of upper idiopathic intestinal pseudo-obstruction associated with JCV infection.
Keywords
JC virus Chronic idiopathic intestinal pseudo-obstruction Gastrointestinal motility disordersAbbreviations
- JCV
JC virus
- CIIPO
Chronic idiopathic intestinal pseudo-obstruction
- SMA
Smooth muscle antibodies
- LKM
Liver kidney microsome antibodies
- AMA
Anti-mitochondrial antibodies
- ANCA
Antineutrophil cytoplasmic antibodies
- ANA
Anti-nuclear antibodies
- TTG
Anti-tissue transglutaminase
- HBV
Hepatitis B virus
- HCV
Hepatitis C virus
- HIV
Human immunodeficiency virus
- CMV
Cytomegalovirus
- EBV
Epstein Barr virus
- HSV
Herpes simplex virus
- CT
Computed tomography
- TPN
Total parenteral nutrition
- PPI
Proton pump inhibitor
- PCR
Polymerase chain reaction
Notes
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent
Informed consent was obtained from all patients for being included in the study.
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