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Could JC virus be linked to chronic idiopathic intestinal pseudo-obstruction?

  • Emanuele Sinagra
  • Dario Raimondo
  • Elena Gallo
  • Marco Calvaruso
  • Vincenzo Luca LentiniEmail author
  • Alessandra Cannizzaro
  • Cristina Linea
  • Marco Giunta
  • Luigi Maria Montalbano
  • Gennaro D’Amico
  • Aroldo Gabriele Rizzo
Case Report
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Abstract

JC virus is a member of the Polyomavirus family, infects humans worldwide, and 90% of the population carry antibodies to the virus by adult life. The initial infection is asymptomatic, but it may become persistent. JC virus DNA is frequently present in the upper and lower gastrointestinal tracts of healthy adults. Chronic idiopathic intestinal pseudo-obstruction, one of the most severe gastrointestinal motility disorders, is a condition characterized by a clinical picture mimicking small bowel occlusion with related symptoms and signs in the absence of demonstrable mechanical obstruction. Because of the known neuropathic capability of this virus, and its frequent presence in the gut, it has been proposed that JCV might be detectable in tissues of patients with chronic idiopathic intestinal pseudo-obstruction, and possibly be involved in the pathogenesis of this disease, because the virus may actively infect the enteroglial cells of the myenteric plexuses of the patients with chronic idiopathic intestinal pseudo-obstruction. We report two cases of upper idiopathic intestinal pseudo-obstruction associated with JCV infection.

Keywords

JC virus Chronic idiopathic intestinal pseudo-obstruction Gastrointestinal motility disorders 

Abbreviations

JCV

JC virus

CIIPO

Chronic idiopathic intestinal pseudo-obstruction

SMA

Smooth muscle antibodies

LKM

Liver kidney microsome antibodies

AMA

Anti-mitochondrial antibodies

ANCA

Antineutrophil cytoplasmic antibodies

ANA

Anti-nuclear antibodies

TTG

Anti-tissue transglutaminase

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HIV

Human immunodeficiency virus

CMV

Cytomegalovirus

EBV

Epstein Barr virus

HSV

Herpes simplex virus

CT

Computed tomography

TPN

Total parenteral nutrition

PPI

Proton pump inhibitor

PCR

Polymerase chain reaction

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Emanuele Sinagra
    • 1
    • 4
  • Dario Raimondo
    • 1
  • Elena Gallo
    • 2
  • Marco Calvaruso
    • 5
  • Vincenzo Luca Lentini
    • 2
    Email author
  • Alessandra Cannizzaro
    • 2
  • Cristina Linea
    • 3
  • Marco Giunta
    • 3
  • Luigi Maria Montalbano
    • 3
  • Gennaro D’Amico
    • 3
  • Aroldo Gabriele Rizzo
    • 2
  1. 1.Endoscopy Unit, Contrada Pietra Pollastra PisciottoFondazione Istituto San Raffaele–G. GiglioCefalùItaly
  2. 2.Unit of Pathology, Ospedali Riuniti “Villa Sofia–CervelloUniversity of PalermoPalermoItaly
  3. 3.Unit of Gastroenterology, Ospedali Riuniti “Villa Sofia–CervelloUniversity of PalermoPalermoItaly
  4. 4.Euro-Mediterranean Institute of Science and Technology (IEMEST)PalermoItaly
  5. 5.Contrada Pietra Pollastra PisciottoIstituto Di Bioimmagini E Fisiologia Molecolare, IBFM-CNRCefalùItaly

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