Carcinoma in situ of the pancreas with pancreatic duct stricture persistent for 4 years diagnosed by serial pancreatic juice aspiration cytologic examination (SPACE)

  • Sawako KurumaEmail author
  • Masataka Kikuyama
  • Kazuro Chiba
  • Kensuke Yoshimoto
  • Terumi Kamisawa
  • Goro Honda
  • Shinichiro Horiguchi
  • Jun Nakahodo
Case Report


Serial pancreatic juice aspiration cytologic examination (SPACE) by nasopancreatic tube placement can give us an opportunity to diagnose early-stage pancreatic cancer with higher sensitivity and specificity compared with conventional pancreatic cytology by one-time pancreatic juice aspiration or pancreatic duct brushing. We performed SPACE in a patient with persistent pancreatic duct stricture (PDS) with gradually advancing pancreatic parenchyma atrophy (PPA) in the pancreas tail. The result of SPACE was suggestive of pancreatic carcinoma, and distal pancreatectomy was performed. Histopathological examination of the resected specimen revealed carcinoma in situ of the pancreas. The present case could indicate that any PDS becomes a candidate for SPACE especially in a patient with PPA, although the PDS remains unchanged for a long period.


Pancreatic duct stricture Serial pancreatic juice aspiration cytologic examination Carcinoma in situ of the pancreas 


Compliance with ethical standards

Conflict of interest

Sawako Kuruma, Masataka Kikuyama, Kazuro Chiba, Terumi Kamisawa, Jun Nakahodo, Goro Honda, Shinichiro Horiguchi, and Kensuke Yoshimoto declare that they have no conflict of interest.

Human rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  1. 1.Department of GastroenterologyTokyo Metropolitan Cancer and Infectious Diseases Komagome HospitalTokyoJapan
  2. 2.Department of SurgeryNew Tokyo HospitalChibaJapan
  3. 3.Department of PathologyTokyo Metropolitan Cancer and Infectious Diseases Komagome HospitalTokyoJapan
  4. 4.Department of Human PathologyJuntendo UniversityTokyoJapan

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