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A rectal neuroendocrine tumor in a patient with Crohn’s disease: a case report and literature review

  • Katsunori Suzuki
  • Masayoshi YamamotoEmail author
  • Yuhi Suzuki
  • Takafumi Kawamura
  • Megumu Kamishima
  • Mayu Sakata
  • Takashi Harada
  • Takuma Kagami
  • Shinya Tani
  • Mihoko Yamade
  • Yasushi Hamaya
  • Satoshi Osawa
  • Ken Sugimoto
  • Kiyotaka Kurachi
  • Hiroya Takeuchi
Case Report
  • 22 Downloads

Abstract

Crohn’s disease is recognized to increase the risk of gastrointestinal malignances. Adenocarcinoma is the most common malignancy in these patients. Association between Crohn’s disease and adenocarcinoma in the small intestine has already been established, however, the association between neuroendocrine tumor and Crohn’s disease remains uncertain. We report a 39-year-old man with Crohn’s disease, who was diagnosed with NET in the rectum. He had suffered from fever and anal pain due to the anal fistula and abscess. The disease state was considered to be resistant to medical treatment. He underwent total proctocolectomy, small bowel resection, anal fistula drainage with ileostomy. Postoperative histology revealed a neuroendocrine tumor in the rectum. His postoperative course was uneventful, and he followed a good course under treatment with infliximab and mercaptopurine hydrate. This case highlights the need of careful observation of resected specimens in light of the possibility of NET, especially those with anal disorders.

Keywords

Neuroendocrine tumor Crohn’s disease Inflammatory bowel disease 

Notes

Compliance with ethical standards

Conflict of interest

Katsunori Suzuki, Masayoshi Yamamoto, Yuhi Suzuki, Takafumi Kawamura, Megumu Kamishima, Mayu Sakata, Takashi Harada, Takuma Kagami, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Ken Sugimoto, Kiyotaka Kurachi and Hiroya Takeuchi declare that they have no conflict of interest.

Human/animal rights

This study does not include any data about human subjects.

Informed consent

This study does not involve human subjects and does not apply to giving informed consent.

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Katsunori Suzuki
    • 1
  • Masayoshi Yamamoto
    • 1
    Email author
  • Yuhi Suzuki
    • 1
  • Takafumi Kawamura
    • 1
  • Megumu Kamishima
    • 1
  • Mayu Sakata
    • 1
  • Takashi Harada
    • 2
  • Takuma Kagami
    • 3
  • Shinya Tani
    • 3
  • Mihoko Yamade
    • 3
  • Yasushi Hamaya
    • 3
  • Satoshi Osawa
    • 4
  • Ken Sugimoto
    • 3
  • Kiyotaka Kurachi
    • 1
  • Hiroya Takeuchi
    • 1
  1. 1.Second Department of SurgeryHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Department of SurgeryHamamatsu Medical CenterHamamatsuJapan
  3. 3.First Department of MedicineHamamatsu University School of MedicineHamamatsuJapan
  4. 4.Department of Endoscopic and Photodynamic MedicineHamamatsu University School of MedicineHamamatsuJapan

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