Clinical Journal of Gastroenterology

, Volume 12, Issue 6, pp 534–538 | Cite as

Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component

  • Yuki Kaneko
  • Shin SaitoEmail author
  • Kazuya Takahashi
  • Rihito Kanamaru
  • Yoshinori Hosoya
  • Hironori Yamaguchi
  • Joji Kitayama
  • Toshiro Niki
  • Alan Kawarai Lefor
  • Naohiro Sata
Case Report


A 68-year-old male was referred with dysphagia. Endoscopic findings showed circular stenosis with a protruding mass in the lower esophagus. Biopsy showed adenocarcinoma and there was no evidence of distant metastases. A subtotal esophagectomy was performed. The resected specimen revealed a mixed neuroendocrine carcinoma with adenocarcinoma. The adenocarcinoma component was on the surface of the tumor and the neuroendocrine component invaded the deeper portion. Immunohistochemically, the neuroendocrine carcinoma component stained positive for cytokeratin 7 and cytokeratin 20, suggesting that the neuroendocrine carcinoma originated from the adenocarcinoma. The adenocarcinoma component stained positive for MUC2, which suggests that the adenocarcinoma component originated from Barrett’s epithelium. Taken together, the neuroendocrine carcinoma may have originated from Barrett’s epithelium. A metastasis to the liver was found 2 months after the surgical resection. Chemotherapy was administered, but there was no response. Most esophageal neuroendocrine carcinomas are accompanied by adenocarcinoma or squamous cell components, suggesting that these carcinomas originate from pluripotent cells in squamous or Barrett’s epithelium. Appropriate chemotherapy for these lesions should be considered based on the cell of origin.


Esophageal neuroendocrine carcinoma Mixed adenoneuroendocrine carcinoma Barrett’s esophagus Origin of neuroendocrine carcinomas 



Squamous cell carcinoma


Computed tomography



The authors declare no conflicts of interests and no funds regarding the publication of this paper.

Compliance with ethical standards

Conflict of interest

Yuki Kaneko, Shin Saito, Kazuya Takahashi, Rihito Kanamaru, Shiro Matsumoto, Yoshinori Hosoya, Hirofumi Fujii, Joji Kitayama, Toshiro Niki, Alan Kawarai Lefor and Naohiro Sata declare that they have no conflict of interest.

Human rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Written informed consent was obtained from the patient for publication of this case report and accompanying images.

Ethical approval

The need for ethical approval for this paper was waived by the committee of Jichi Medical University Hospital.


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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Yuki Kaneko
    • 1
  • Shin Saito
    • 1
    Email author
  • Kazuya Takahashi
    • 1
  • Rihito Kanamaru
    • 1
  • Yoshinori Hosoya
    • 1
  • Hironori Yamaguchi
    • 3
  • Joji Kitayama
    • 1
  • Toshiro Niki
    • 2
  • Alan Kawarai Lefor
    • 1
  • Naohiro Sata
    • 1
  1. 1.Department of SurgeryJichi Medical UniversityShimotsukeJapan
  2. 2.Department of PathologyJichi Medical UniversityShimotsukeJapan
  3. 3.Department of Clinical OncologyJichi Medical UniversityShimotsukeJapan

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