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Pancreatic cancer and obesity: epidemiology, mechanism, and preventive strategies

  • Prashanth RawlaEmail author
  • Krishna Chaitanya Thandra
  • Tagore Sunkara
Clinical Review

Abstract

The prevalence of obesity has seen a global increase in the past decades, escalating to one of the major epidemiological challenges today. Global economic growth has caused changes in dietary and physical activity patterns fueling obesity across age, gender, and income groups. The implications are many, as obesity has been associated with numerous serious health conditions, ultimately affecting morbidity and mortality. There is a growing recognition of the risk a high body mass index confers on the development and outcome of several malignancies, including pancreatic cancer. Pancreatic cancer is a highly lethal disease with exceptionally poor outcome, with incidences rising worldwide. Due to vague symptoms and no screening recommendations, a vast majority of patients are diagnosed at late stages, with already advanced disease and no opportunity for surgical intervention. Obesity mediates risk for pancreatic cancer through insufficiently understood mechanisms, possibly including inflammation and hormonal misbalance. As excess abdominal adiposity is among the few modifiable risk factors for pancreatic cancer onset, enduring weight loss could manifest an effective preventive measure. Lifestyle modifications on a population level aimed to reduce obesity could also scale down the grim pancreatic cancer rates. In cases when these measures alone are insufficiently effective, bariatric surgery can be an advantageous alternative. Extremely obese patients exhibit many health benefits following bariatric surgery along with weight loss, consequently reducing the chances of pancreatic cancer, especially if additionally adopting healthy lifestyle habits.

Keywords

Obesity Pancreatic cancer Epidemiology Weight loss Bariatric surgery 

Notes

Author contributions

Conception and design, analysis and interpretation, drafting of the article, critical revision of the article and final approval of the article: PR, KCT, TS.

Funding

No funding to disclose.

Compliance with ethical standards

Conflict of interest

None of the authors have a conflict of interest.

Ethics approval

No ethics approval needed.

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine/HospitalistSOVAH HealthMartinsvilleUSA
  2. 2.Department of Pulmonary and Critical Care MedicineSentara Virginia Beach General HospitalVirginia BeachUSA
  3. 3.Division of Gastroenterology and HepatologyMercy Medical CenterDes MoinesUSA

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