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Clinical Journal of Gastroenterology

, Volume 11, Issue 6, pp 481–486 | Cite as

Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases

  • Yoshiaki Isono
  • Youichirou Baba
  • Katsumi Mukai
  • Hiroki Asakawa
  • Kenji Nose
  • Satomi Tsuruga
  • Tomomasa Tochio
  • Hiroaki Kumazawa
  • Hiroki Tanaka
  • Shimpei Matsusaki
  • Tomohiro Sase
  • Tomonori Saito
  • Hiroshi Okano
  • Hideki Toyoda
Case Report
  • 83 Downloads

Abstract

We experienced two cases of adenocarcinoma coexisting with a hyperplastic polyp arising from Helicobacter pylori-negative normal gastric mucosa. The first case was of a 59-year-old man. Esophagogastroduodenoscopy revealed a protruding lesion measuring 4 mm in diameter on the greater curvature of the middle gastric body. The second case was of a 47-year-old man. Esophagogastroduodenoscopy showed a protruding lesion measuring 5 mm located at the greater curvature of the upper gastric body. The absence of atrophic changes in the entire gastric mucosa was confirmed endoscopically in both cases. Multiple H. pylori tests were all negative. Endoscopically, these protruding lesions appeared as reddish, semipedunculated polyps. Hyperplastic polyps were suspected based on white light endoscopic findings. Magnified endoscopy with narrow band imaging could not predict the coexistence of cancer. However, histopathological examination of the resected specimen revealed focal cancer at the surface of the gastric hyperplastic polyps. Considering the possibility that cancer may be coexisting in polyps, when reddish polyps are detected in H. pylori-negative normal gastric mucosa, it is important to perform a biopsy, or a careful follow-up endoscopy.

Keywords

Gastric cancer Helicobacter pylori-negative Gastric hyperplastic polyp 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human/animal rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 of Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients being included in the study.

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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  • Yoshiaki Isono
    • 1
  • Youichirou Baba
    • 2
  • Katsumi Mukai
    • 1
  • Hiroki Asakawa
    • 1
  • Kenji Nose
    • 1
  • Satomi Tsuruga
    • 1
  • Tomomasa Tochio
    • 1
  • Hiroaki Kumazawa
    • 1
  • Hiroki Tanaka
    • 1
  • Shimpei Matsusaki
    • 1
  • Tomohiro Sase
    • 1
  • Tomonori Saito
    • 1
  • Hiroshi Okano
    • 1
  • Hideki Toyoda
    • 3
  1. 1.Department of GastroenterologySuzuka General HospitalSuzukaJapan
  2. 2.Department of PathologySuzuka General HospitalSuzukaJapan
  3. 3.Happy GI ClinicKameyamaJapan

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