Clinical Journal of Gastroenterology

, Volume 11, Issue 6, pp 441–448 | Cite as

Hypertriglyceridemia-induced pancreatitis: updated review of current treatment and preventive strategies

  • Prashanth RawlaEmail author
  • Tagore Sunkara
  • Krishna Chaitanya Thandra
  • Vinaya Gaduputi
Clinical Review


Hypertriglyceridemia (HTG) is an uncommon but well-established cause of acute pancreatitis (AP) comprising up to 7% of the cases. The clinical course of HTG-induced pancreatitis (HTGP) is highly similar to that of AP of other etiologies with HTG being the only distinguishing clinical feature. However, HTGP is often correlated with higher severity and elevated complication rate. At present, no approved treatment guideline for the management of HTGP is available, although different treatment modalities such as insulin, heparin, fibric acids, and omega 3 fatty acids have been successfully implemented to reduce serum triglycerides (TG). Plasmapheresis has also been used to counteract elevated TG levels in HTGP patients. However, it has been associated with complications. Following the management of acute phase, lifestyle modifications including dietary adjustments and drug therapy are essential in the long-term management of HTGP and the prevention of its relapse. Results from studies of small patient groups describing treatment and prevention of HTGP are not sufficient to draw solid conclusions resulting in no treatment algorithm being available for effective management of HTGP. Therefore, prospective randomized, active-controlled clinical studies are required to find a better treatment regimen for the management of HTGP. Until date, one randomized clinical trial has been performed to compare clinical outcomes of different treatment approaches for HTGP. However, further studies are required to outline a generalized and efficient treatment regimen for the management of HTGP.


Hypertriglyceridemia Acute pancreatitis Insulin Heparin Plasmapheresis Recurrent pancreatitis 


Author Contributions

Conception and design: PR, M.D; TS, M.D. Analysis and interpretation: PR, M.D; TS, M.D; KCT, M.D, VG, M.D. Drafting of the article: PR, M.D; TS, M.D; KCT, M.D, VG, M.D. Critical revision of the article: PR, M.D; TS, M.D; KCT, M.D, VG, M.D. Final approval of the article: PR, M.D; TS, M.D; KCT, M.D, VG, M.D.


No funding to disclose.

Compliance with ethical standards

Conflict of interest

Prashanth Rawla, Tagore Sunkara, Krishna Chaitanya Thandra, and Vinaya Gaduputi declare that they have no conflict of interest.

Human/animal rights

This study does not include any data about human subjects.

Informed consent

This study does not involve human subjects and does not apply to giving Informed Consent.


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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine/HospitalistSOVAH HealthMartinsvilleUSA
  2. 2.Division of Gastroenterology and Hepatology, The Brooklyn Hospital CenterClinical Affiliate of the Mount Sinai HospitalNew YorkUSA
  3. 3.Department of Critical Care MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA
  4. 4.Division of GastroenterologySBH Health SystemBronxUSA

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