Pancreatic metastasis of papillary thyroid carcinoma preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy: a case report with review of literatures
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Pancreatic metastatic tumors from thyroid carcinoma are extremely rare. We report a case of an 80-year-old female with a pancreatic metastatic tumor derived from papillary thyroid carcinoma which was initially resected 158 months prior to detection of the metastatic pancreatic tumor. The patient has encountered cervical lymph-node metastasis on three occasions following the initial operation. Metastatic pancreatic lesions and cervical lymph nodes were first detected using 18-fluorodeoxyglucose positron-emission tomography/computed tomography, and she was preoperatively diagnosed using endoscopic ultrasound-guided fine-needle aspiration biopsy. A coin lesion, 10 mm in size, was detected in the left lung by chest computed tomography with no abnormal uptake in 18-fluorodeoxyglucose positron-emission tomography/computed tomography. Distal pancreatectomy and cervical lymph-node dissection were performed. Adjuvant chemotherapy with weekly paclitaxel was administered because anaplastic transformation had been detected in one of the cervical lymph nodes. The patient eventually died from multiple lung metastases 11 months after removing the metastatic pancreatic lesion. We reported a rare case of a pancreatic metastatic tumor from thyroid carcinoma, and found that 18-fluorodeoxyglucose positron-emission tomography/computed tomography and endoscopic ultrasound-guided fine-needle aspiration biopsy are useful for preoperatively diagnosing tumors.
KeywordsPancreatic metastasis Papillary thyroid carcinoma Endoscopic ultrasound-guided fine-needle aspiration biopsy 18-Fluorodeoxyglucose positron-emission tomography/computed tomography
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Conflict of interest
Yuko Murakami, Tatsuo Shimura, Ryo Okada, Yasuhide Kofunato, Teruhide Ishigame, Rei Yashima, Keiichi Nakano, Shinichi Suzuki, and Seiichi Takenoshita declare that they have no conflict of interest.
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent was obtained from all patients for being included in the study.
- 5.Brierly JD. Thyroid gland. In: Brierley JD, Gospodarowicz MK, Wittekind C, editors. TNM classification of malignant tumours. 8th ed. Oxford: Wiley; 2017. pp. 51–4.Google Scholar
- 7.Braverman LE, Cooper DS. Staging and prognosis of differentiated thyroid cancer. Werner and Ingbar’s the thyroid. A fundamental and clinical text. 10th ed. Philadelphia: Lippincott Williams and Wilkins; 2012.Google Scholar
- 22.Hoshimoto S, Aiura K, Ueda M, et al. Resection of pancreatic metastases originating from papillary carcinoma of the thyroid. A case report. J Jpn Panc Soc. 2004;19:410–5.Google Scholar
- 25.Urakami A, Hirabayashi Y, Matsumoto H, et al. A case of multiple pancreatic metastases from thyroid papillary carcinoma treated by total pancreatectomy. Kawasaki Med J. 2012;38:211–7.Google Scholar
- 26.Sato T, Isotani E, Nakagawa T, et al. A case of pancreatic metastasis from a papillary thyroid carcinoma. J Abdom Emerg Med. 2013;33:1275–9.Google Scholar
- 27.Ohtawa T, Aoyama T, Yoshikawa K, et al. Pancreatic metastasis of papillary carcinoma of the thyroid—report of a resected case. J Biliary Tract Pancreas. 1997;18:199–203.Google Scholar
- 28.Naritomi M, Hatake S, Kobayasi H, et al. A case of pancreatic metastasis from papillary thyroid carcinoma diagnosed by pancreatic duct lavage cytology. Okayama Bull Jpn Soc Clin Cytol. 2011;30:37–9.Google Scholar
- 29.Kano S, Kiriyama M, Hagino S, et al. A case of resected pancreatic metastasis from a papillary thyroid carcinoma. Rinsho Geka (J Clin Surg). 2015;70:1403–8.Google Scholar
- 30.Ichikawa K, Kono M, Kondo A, et al. Resection of a pancreatic metastasis from follicular thyroid carcinoma. Rinsho Geka (J Clin Surg). 2015;70:1530–4.Google Scholar