Clinical Journal of Gastroenterology

, Volume 11, Issue 2, pp 138–144 | Cite as

Isolated breast metastasis from gastric cancer in a male patient

  • Hirokazu Kubo
  • Tetsuya Shimizu
  • Hitoshi Sekido
  • Goro Matsuda
  • Kazuhisa Takeda
  • Akira Watanabe
  • Risa Sakamoto
  • Yuji Yamamoto
  • Junya Toyoda
  • Hitoshi Niino
Case Report
  • 95 Downloads

Abstract

A 72-year-old man underwent total gastrectomy for gastric cancer (por2, T3, N2, Stage IIIA). Eleven courses of postoperative chemotherapy with TS-1 (tegafur/gimeracil/oteracil) were administered. Five months after surgery, the serum carcinoembryonic antigen value was slightly elevated. However, computed tomography did not reveal any metastatic lesions in other organs. Two years after surgery, the patient felt a mass in the left mammary. A 2-cm tumor was palpable in the central portion of the breast. Ultrasonography revealed a hypoechoic tumor, which was Class 3 on aspiration biopsy cytological examination. No mass was detected on positron emission tomography–computed tomography. The mammary gland tumor increased in size to 3 cm, and a core needle biopsy procedure was performed. Histological examination findings revealed breast metastasis of gastric cancer. No other recurrence was found, and radical mastectomy was performed 2 years and 5 months after gastrectomy. Immunohistological analysis of the resected material confirmed breast metastasis of the gastric cancer. Two courses of TS-1 + cisplatin were administered, but this treatment was subsequently terminated because the patient experienced Grade 3 diarrhea and neutropenia. Three years and 1 month after the gastrectomy, the tumor recurred in the pelvic area. Chemotherapy and radiation therapy were performed, but the patient’s overall condition became progressively worse, and he died 3 years and 9 months after gastrectomy.

Keywords

Gastric cancer Breast metastasis Male 

Notes

Compliance with ethical standards

Conflict of interest:

Hirokazu Kubo, Tetsuya Shimizu, Hitoshi Sekido, Goro Matsuda, Kazuhisa Takeda, Akira Watanabe, Risa Sakamoto, Yuji Yamamoto, Junya Toyoda, and Hitoshi Niino declare that they have no conflict of interest.

Human/animal Rights:

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent:

Informed consent was obtained from all patients for being included in the study.

References

  1. 1.
    Lee SK, Kim WW, Kim SH, et al. Characteristics of metastasis in the breast from extramammary malignancies. J Surg Oncol. 2010;101:137–40.CrossRefPubMedGoogle Scholar
  2. 2.
    Stahr H. Plastische mastitis bei magenkrebs [Plastic mastitis caused by gastric carcinoma]. Z Krebsforsch. 1922;19:231 (Dutch).CrossRefGoogle Scholar
  3. 3.
    Feder JM, de Paredes ES, Hogge JP, et al. Unusual beast lesions: radiologic–pathologic correlation. Radiographics. 1999;19:S11–26 (quiz S260).CrossRefPubMedGoogle Scholar
  4. 4.
    Kwak JY, Kim EK, Oh KK. Radiologic findings of metastatic signet ring cell carcinoma to the breast from stomach. Yonsei Med J. 2000;41:669–72.CrossRefPubMedGoogle Scholar
  5. 5.
    Reitmann K. Das sekundare Karzinom der Haut bei primaren Karzi- nom innerer Organe [The secondary carcinoma of skin from primary carcinoma of inner organ]. Arch Dermatol Syph. 1908;90:351 (Dutch).CrossRefGoogle Scholar
  6. 6.
    Kreibich C. Uber sekundaren Szirrhus der Haut. Med Klin. 1909;5:1436.Google Scholar
  7. 7.
    Mourier F, Marre L. Envahissement du sein, cancer de l’estomac [Invasion to breast, cancer of stomach]. Arch Med Exp Anat Pathol. 1910;22:433 (French).Google Scholar
  8. 8.
    Dawson EK. Metastatic tumour of the breast, with report of a case. J Pathol. 1936;43:53.CrossRefGoogle Scholar
  9. 9.
    Abrams HL, Spiro R, Goldstein N. Metastasis in carcinoma. Cancer. 1949;3:74–85.CrossRefGoogle Scholar
  10. 10.
    Sandison AT. Metastatic tumours in the breast. Br J Surg. 1959;47:54.CrossRefPubMedGoogle Scholar
  11. 11.
    Nance FC, MacVaugh H 3rd, Fitts WT Jr. Metastatic tumor to the breast simulating bilateral primary inflammatory carcinoma. Am J Surg. 1966;112:932–5.CrossRefPubMedGoogle Scholar
  12. 12.
    Hadju SI, Urban JA. Cancers metastatic to the breast. Cancer. 1972;29:1691–6.CrossRefGoogle Scholar
  13. 13.
    Schmutzer KJ, Zaki AE, Regan JF. Gastric carcinoma in a 22-year-old negro woman with metastases to ovaries and breast. J Natl Med Assoc. 1973;65:426–8.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Silverman EM, Oberman HA. Metastatic neoplasms in the breast. Surg Gynecol Obstet. 1974;138:26–8.PubMedGoogle Scholar
  15. 15.
    Toombs BD, Kalisher L. Metastatic disease to the breast. Clinical patho-logic and radiographic features. Am J Roentgenol. 1977;129:673.CrossRefGoogle Scholar
  16. 16.
    Satake T, Esaki M. A metastatic case to the breast of stomach cancer. Gan To Kagaku Ryoho. 1980;26:577–80.Google Scholar
  17. 17.
    Togo S, Kasumi F. A case of gastric cancer metastatic to the breast. Gan No Rinsho. 1980;26:386–93.Google Scholar
  18. 18.
    Nielsen M, Andersen JA, Henriksen FW, et al. Metastases to the breast from extramammary carcinomas. Acta Pathol Microbiol Immunol Scand. 1981;89:251–5.Google Scholar
  19. 19.
    Champault G, Ascher E, Guterman R, et al. Cancer of the breast and gastric linitis. Metastasis or coincidence? Ann Chir. 1982;36:246–8.PubMedGoogle Scholar
  20. 20.
    Kasuga Y, Senga O, Hanamura N, et al. A case of bilateral metastatic breast carcinoma from gastric carcinoma (Jpn). Gan No Rinsho. 1986;32:407–12.PubMedGoogle Scholar
  21. 21.
    Tachibana S, Asano M, Miya K, et al. A case report of gastric cancer with breast metastasis (Jpn). J Clin Surg. 1986;41:1719–22.Google Scholar
  22. 22.
    Alexander HR, Turnbull AD, Rosen PP. Isolated breast metastases from gastrointestinal carcinomas: report of two cases. J Surg Oncol. 1989;42:264–6.CrossRefPubMedGoogle Scholar
  23. 23.
    Hamby LS, McGrath PC, Cibull ML, Schwarts RW. Gastric carcinoma metastic to the breast. J Surg Oncol. 1991;48:117–21.CrossRefPubMedGoogle Scholar
  24. 24.
    Mishina Y, Ohtsuka K, Yamamura H, et al. A case or metastasis of gastric cancer to the mammary gland (Jpn). J Jpn Surg Assoc. 1993;54:112–7.Google Scholar
  25. 25.
    Cavazzini G, Colpani F, Cantore M, et al. Breast metastasis from gastric signet ring cell carcinoma, mimicking inflammatory carcinoma. A case report. Tumori. 1993;179:450–3.Google Scholar
  26. 26.
    Domanski HA. Metastases to the breast from extramammary neoplasms. A report of six cases with diagnosis by fine needle aspiration cytology. Acta Cytol. 1996;40:1293–300.CrossRefPubMedGoogle Scholar
  27. 27.
    De la Cruz Mera A, Marino Cotelo A. Breast metastases. Acta Cytol. 1998;42:1304–6.Google Scholar
  28. 28.
    Briest S, HornLC Haupt R, Schneider JP, et al. Metastasizing signet ring cell carcinoma of the stomach, mimicking bilateral inflammatory breast cancer. Gynecol Oncol. 1999;74:491–4.CrossRefPubMedGoogle Scholar
  29. 29.
    Kudo H, Sakatani T, Shibata S, Ishiguro M, et al. A case of gastric cancer metastasized to the breasts (Jpn). J Jpn Surg Assoc. 1999;60:1486–9.CrossRefGoogle Scholar
  30. 30.
    Madan AK, Ternovits C, Huber SA, et al. Gastrointestinal metastasis to the breast. Surgery. 2002;132:889–93.CrossRefPubMedGoogle Scholar
  31. 31.
    Di Cosimo S, Ferreti G, Fazio N, et al. Breast and ovarian meta- static localization of signet-ring cell gastric carcinoma. Ann Oncol. 2003;14:803–4.CrossRefPubMedGoogle Scholar
  32. 32.
    Boutis AL, Andreadis C, Patakiouta F, et al. Gastric signet-ring adenocarcinoma presenting with breast metastasis. World J Gastroenterol. 2006;12:2958–61.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Qureshi SS, Shrikhande SV, Tanuja S, et al. Breast metastases of gastric signet ring cell carcinoma: a differential diagnosis with primary breast signet ring cell carcinoma. J Postgrad Med. 2005;51:125–7.PubMedGoogle Scholar
  34. 34.
    Isobe T, Tokoyama G, Fujii T, et al. A case of breast metastasis of gastric cancer progressed rapidly (Jpn). J Jpn Surg Assoc. 2006;67:2800–4.CrossRefGoogle Scholar
  35. 35.
    Hasegawa S, Yoshikawa T, Yoshida T, et al. A case of breast metastasis of gastric cancer (Jpn). Jpn J Cancer Chemother. 2007;34:1115–8.Google Scholar
  36. 36.
    Krichen Makni S, Abbes K, Khanfir A, et al. Metastatic signet ring cell carcinoma to the breast from stomach (Fre). Cancer Radiother. 2007;11:276–9.CrossRefPubMedGoogle Scholar
  37. 37.
    Gugić D, Josipa F, Šambić PM, et al. Breast metastases from gastric carcinoma—a case report. Libri Oncol. 2007;35:59–62.Google Scholar
  38. 38.
    Sato T, Muto I, Fushiki M, et al. Metastatic breast cancer from gastric and ovarian cancer, mimicking inflammatory breast cancer: report of two cases. Breast Cancer. 2008;15:315–20.CrossRefPubMedGoogle Scholar
  39. 39.
    Timuçin Ç, Abdullah A, Semir P, et al. Gastric ring cell carcinoma metastasis to the breast: two case reports. Turk J Cancer. 2009;39:62–5.Google Scholar
  40. 40.
    Parrell Soler C, Palacios Marques A, Saco Lopez L, et al. Breast metastatic localization of signet-ring cell gastric carcinoma ISRN. Obstet Gynecol. 2011;2011:426150.Google Scholar
  41. 41.
    Iesato A, Oba T, Ono M, et al. Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature. Onco Targets Ther. 2015;8:91–7.PubMedGoogle Scholar
  42. 42.
    He Chun-Lan, Chen Ping, Xiao Bing-Lan, et al. Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review. World J Surg Oncol. 2015;13:120.  https://doi.org/10.1186/s12957-015-0538-1.CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Bariest S, Horn LC, Haupt R, et al. Metastasizing signet ring cell carcinoma of the stomach-mimicking bilateral inflammatory breast cancer. Gynecol Oncol. 1999;74:491–4.CrossRefGoogle Scholar
  44. 44.
    Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol. 2008;19:1523–9.CrossRefPubMedGoogle Scholar
  45. 45.
    Hadju SI, Urban JA. Cancers metastatic to the breast. Cancer. 1972;29:1691–6.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  1. 1.Department of SurgeryNational Hospital Organization Yokohama Medical CenterYokohamaJapan

Personalised recommendations