Clinical Journal of Gastroenterology

, Volume 10, Issue 4, pp 336–341 | Cite as

Primary malignant melanoma of esophagus following chemoradiotherapy for esophageal squamous cell carcinoma: report of a case

  • Shinichiro ImaiEmail author
  • Akira Suzuki
  • Yuta Yamamoto
  • Makoto Koyama
  • Satoshi Sugiyama
  • Masato Kitazawa
  • Yusuke Miyagawa
  • Shinichi Miyagawa
Case Report


Primary malignant melanoma of the esophagus (PMME) is a rare neoplasm. We observed a case of PMME that had occurred at an irradiated site in the thoracic esophagus. The patient was a 74-year-old man who had received definitive chemoradiotherapy for esophageal squamous cell carcinoma at the age of 68, and had completely recovered. Six years later, via periodic upper gastrointestinal endoscopy, he had been diagnosed with esophageal tumors. After the patient underwent esophagectomy, the removed esophageal tumors were immunohistologically diagnosed as PMME, and most of the tumor was observed to be located within the irradiated area corresponding to the previous radiotherapy. The patient has been free of recurrence and metastasis and alive for 20 months after the second surgery without any additional treatment. The clinical course of this patient suggests that therapeutic radiation may be a factor in the occurrence of PMME.


Malignant melanoma Esophagus Radiotherapy 



We thank Dr. Takeshi Uehara in the Department of the Clinical Laboratory, Shinshu University School of Medicine for the pathological diagnosis of this case.

Compliance with ethical standards

Conflict of interest

Shinichiro Imai, Akira Suzuki, Yuta Yamamoto, Makoto Koyama, Satoshi Sugiyama, Masato Kitazawa, Yusuke Miyagawa and Shinichi Miyagawa declare that they have no conflict of interest.

Human/animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed consent

Informed consent was obtained from the patient to be included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2017

Authors and Affiliations

  • Shinichiro Imai
    • 1
    Email author
  • Akira Suzuki
    • 1
  • Yuta Yamamoto
    • 1
  • Makoto Koyama
    • 1
  • Satoshi Sugiyama
    • 1
  • Masato Kitazawa
    • 1
  • Yusuke Miyagawa
    • 1
  • Shinichi Miyagawa
    • 1
  1. 1.Department of SurgeryShinshu University School of MedicineMatsumotoJapan

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