Clinical Journal of Gastroenterology

, Volume 8, Issue 6, pp 367–376 | Cite as

Adenocarcinoma of the cervical esophagus arising from ectopic gastric mucosa: report of two cases and review of the literature

  • Kosuke Nomura
  • Toshiro Iizuka
  • Naoko Inoshita
  • Yasutaka Kuribayashi
  • Takahito Toba
  • Akihiro Yamada
  • Satoshi Yamashita
  • Tsukasa Furuhata
  • Daisuke Kikuchi
  • Akira Matsui
  • Toshifumi Mitani
  • Osamu Ogawa
  • Shu Hoteya
  • Masaki Ueno
  • Harushi Udagawa
  • Mitsuru Kaise
Case Report

Abstract

Esophageal adenocarcinoma arising from ectopic gastric mucosa (EGM) is extremely rare. We describe here two Japanese patients with adenocarcinoma of the cervical esophagus arising from EGM. Case 1 is a 62-year-old man who had slightly red EGM in the cervical esophagus on upper gastrointestinal endoscopy (UGE). Because the biopsy showed atypical glands that were suspicious for adenocarcinoma, endoscopic submucosal dissection was performed. Histopathological examination revealed that the lesion was a well-differentiated adenocarcinoma (pT1a MM). Lymphovascular invasion was absent, and the margins were free from carcinoma. Case 2 is a 57-year-old man who had an elevated lesion with a bleeding tendency in an area of EGM in the cervical esophagus on UGE. Adenocarcinoma was diagnosed in the biopsy. Because of the presence of enlarged lymph nodes (#106recL), preoperative chemoradiotherapy was performed to reduce the size of the adenocarcinoma and lymph nodes prior to resection of the cervical esophagus and reconstruction with free jejunal grafts. Histopathological examination revealed moderately differentiated adenocarcinoma (0-I, pT2N1M0, pStage II). In both cases, adenocarcinoma was surrounded by EGM, which led to the diagnosis of EGM-derived esophageal adenocarcinoma. Here, we report its immunohistochemical characteristics in the present cases and discuss the histogenesis.

Keywords

Esophageal adenocarcinoma Ectopic gastric mucosa Cervical esophagus 

Notes

Compliance with ethical standards:

Conflict of Interest:

Kosuke Nomura, Toshiro Iizuka, Naoko Inoshita, Yasutaka Kuribayashi, Takahito Toba, Akihiro Yamada, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani,Osamu Ogawa, Shu Hoteya, Masaki Ueno, Harushi Udagawa and Mitsuru Kaise have no conflict of interest.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent:

Informed consent was obtained from all patients for being included in the study.

Funding:

None.

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Copyright information

© Japanese Society of Gastroenterology 2015

Authors and Affiliations

  • Kosuke Nomura
    • 1
  • Toshiro Iizuka
    • 1
  • Naoko Inoshita
    • 2
  • Yasutaka Kuribayashi
    • 1
  • Takahito Toba
    • 1
  • Akihiro Yamada
    • 1
  • Satoshi Yamashita
    • 1
  • Tsukasa Furuhata
    • 1
  • Daisuke Kikuchi
    • 1
  • Akira Matsui
    • 1
  • Toshifumi Mitani
    • 1
  • Osamu Ogawa
    • 1
  • Shu Hoteya
    • 1
  • Masaki Ueno
    • 3
  • Harushi Udagawa
    • 3
  • Mitsuru Kaise
    • 1
  1. 1.Department of GastroenterologyToranomon HospitalTokyoJapan
  2. 2.Department of PathologyToranomon HospitalTokyoJapan
  3. 3.Department of Digestive SurgeryToranomon HospitalTokyoJapan

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